DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and ALE2

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_849998.1	Gene:	ALE2 / 816549	AraportID:	AT2G20300	Length:	744	Species:	Arabidopsis thaliana

Alignment Length:	532	Identity:	138/532 - (25%)
Similarity:	229/532 - (43%)	Gaps:	99/532 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PVRAQLCAHLDALDVWQ-----QLATAVKLYPDQVEQISSQKQRGRSASNE-------FLNI--W 90
            |::.||...:....::.     ::..|...|.:|    |..|..|.||.:|       .:|:  .
plant   120 PMKVQLLLSVAPFSIFPVTNELEIEVAAGTYLEQ----SQVKIMGASADSENQGKTVVDINLVPL 180

  Fly    91 GGQYNHTVQTL-FALFKKLKLHNAMRLIKDY-VSEDLHKYIPRSVPTISELRAAPDSSAKVNNGP 153
            |.::::|..|| :..|:..|:.....:..|| |:...:..||.|.|.       .|.:.....|.
plant   181 GEKFDNTTATLIYQRFRHKKVPLNETVFGDYEVTHISYPGIPSSSPN-------GDVTGDAPGGL 238

  Fly   154 PFP--------SSSGVS-------------------------------NSNNNRTSTTATEEIPS 179
            |.|        .|.|:.                               ..::|.........|..
plant   239 PIPINATTFANKSQGIGFRTIAIIALSGFVLILVLVGAISIIVKWKKIGKSSNAVGPALAPSINK 303

  Fly   180 LESLGNIH------------ISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKW 232
            ....|::.            :|::...|.|:.....:|||.|||.:|....||:||||.||:|..
plant   304 RPGAGSMFSSSARSSGSDSLMSSMATCALSVKTFTLSELEKATDRFSAKRVLGEGGFGRVYQGSM 368

  Fly   233 KQ-LDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKG 296
            :. .:||:|::...:.|.|::.:.      |::.|:.:.|.|::.|.|..|:|...||:|:|:..
plant   369 EDGTEVAVKLLTRDNQNRDREFIA------EVEMLSRLHHRNLVKLIGICIEGRTRCLIYELVHN 427

  Fly   297 GSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPK 361
            ||:|:.|  |:.     .|.|..|..|:||.|||:.:||......:||.|.|.:|:||:....||
plant   428 GSVESHL--HEG-----TLDWDARLKIALGAARGLAYLHEDSNPRVIHRDFKASNVLLEDDFTPK 485

  Fly   362 IGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDR 426
            :.||||.||..:....:  ..:|.||..|:.||:.....|....||||:|:||||:.|||:..|
plant   486 VSDFGLAREATEGSQHI--STRVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLTGRRPVD- 547

  Fly   427 VPENETKKNLLDYVKQQW--RQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMN 489
            :.:...::||:.:.:...  |:...:|::..||.....: ||...|..|.: |...:...||.|.
plant   548 MSQPSGEENLVTWARPLLANREGLEQLVDPALAGTYNFD-DMAKVAAIASM-CVHQEVSHRPFMG 610

  Fly   490 AVLKRFEPFVTD 501
            .|::..:....|
plant   611 EVVQALKLIYND 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	22/103 (21%)
		STKc_IRAK	219..498	CDD:270968	92/281 (33%)
		TyrKc	219..495	CDD:197581	92/278 (33%)
ALE2	NP_849998.1	STKc_IRAK	355..619	CDD:270968	92/281 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870