DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pll and FRK1

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_179509.1	Gene:	FRK1 / 816436	AraportID:	AT2G19190	Length:	876	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	142/560 - (25%)
Similarity:	222/560 - (39%)	Gaps:	137/560 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TMAIRLLPLPVRAQLCAHLDALDVWQ-----QLATAVKLYPDQVEQISSQKQRGRSASNEFLNIW 90
            |:...||..|....|...::||:|:|     |:.|    :|..|:.:...|...|...|     |
plant   333 TINFSLLQPPGEFVLPPIINALEVYQVNEFLQIPT----HPQDVDAMRKIKATYRVKKN-----W 388

  Fly    91 GGQ--------------------YNHTVQTLFALFKKLK------LHNAMRLIK-DYVSEDLHKY 128
            .|.                    .|..|.:|...|.:|:      ..|...:.| |.....|...
plant   389 QGDPCVPVDYSWEGIDCIQSDNTTNPRVVSLNISFSELRGQIDPAFSNLTSIRKLDLSGNTLTGE 453

  Fly   129 IP---RSVPTISELRAAPDS------------------SAKVNNGPPFPSSSGVSNS---NNN-- 167
            ||   .::|.::||....:.                  |.:....|....|...||:   |.|
plant   454 IPAFLANLPNLTELNVEGNKLTGIVPQRLHERSKNGSLSLRFGRNPDLCLSDSCSNTKKKNKNGY 518

  Fly   168 -------------RTSTTATEEIPSLESLG-----NIHISTVQRAAESLLEIDYAELENATDGWS 214
                         .|:..........:..|     |..:.|.:|      ...|:|:.|.|:.:
plant   519 IIPLVVVGIIVVLLTALALFRRFKKKQQRGTLGERNGPLKTAKR------YFKYSEVVNITNNF- 576

  Fly   215 PDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELK----YLNSIRHDNIL 275
             :..:|:||||.||.|......||:||::..|          .|.|.|.:    .|..:.|.|:.
plant   577 -ERVIGKGGFGKVYHGVINGEQVAVKVLSEES----------AQGYKEFRAEVDLLMRVHHTNLT 630

  Fly   276 ALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGT 340
            :|.||..:.....|:|:.|...:|...|...::.    .|:|::|..|||..|:|:.:||.....
plant   631 SLVGYCNEINHMVLIYEYMANENLGDYLAGKRSF----ILSWEERLKISLDAAQGLEYLHNGCKP 691

  Fly   341 PLIHGDIKPANILLDQCLQPKIGDFGLVR----EGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQL 401
            |::|.|:||.||||::.||.|:.||||.|    ||...:..||.     |:..||.||:.:.||:
plant   692 PIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVA-----GSIGYLDPEYYSTRQM 751

  Fly   402 STGVDVYSFGIVLLEVFTGRQVTDRVPENETKK-NLLDYVKQQWRQNRM------ELLEKHLAAP 459
            :...||||.|:|||||.||:..   :..::|:| ::.|:|:.......:      .|.|::   .
plant   752 NEKSDVYSLGVVLLEVITGQPA---IASSKTEKVHISDHVRSILANGDIRGIVDQRLRERY---D 810

  Fly   460 MGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPFV 499
            :|....|.    |..|.||......||:|:.|:...:..|
plant   811 VGSAWKMS----EIALACTEHTSAQRPTMSQVVMELKQIV 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	26/127 (20%)
		STKc_IRAK	219..498	CDD:270968	93/293 (32%)
		TyrKc	219..495	CDD:197581	93/290 (32%)
FRK1	NP_179509.1	Malectin_like	33..358	CDD:289580	8/24 (33%)
		leucine-rich repeat	396..415	CDD:275380	1/18 (6%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..463	CDD:275380	5/22 (23%)
		leucine-rich repeat	464..479	CDD:275380	2/14 (14%)
		STYKc	576..839	CDD:214568	92/293 (31%)
		STKc_IRAK	580..845	CDD:270968	93/293 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870