Protein Alignment pll and Irak3

DIOPT Version :10

• Sequence 1: NP_476971.1
• Gene: pll / 43283
• FlyBaseID: FBgn0010441
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_082955.2
• Gene: Irak3 / 73914
• MGIID: 1921164
• Length: 609
• Species: Mus musculus
• Alignment Length: 510
• Identity: 141/510 - (27%)
• Similarity: 214/510 - (41%)
• Gaps: 90/510 - (17%)

  Fly    21 RTRSRSHLDNTMAIRLLPLPVRAQLCAHLDALD---VWQQLATAVKLYPDQVEQISSQKQRGRSA 82
            |..:|..|...:.:..||..:..:||..||:.|   .|:.||..:......|..|.....:|:|.
Mouse     4 RCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSG 68

  Fly    83 SNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDY-VSEDLHKYIPRSVPTISELRAAPDSS 146
            :.|.|..| .|.|.|:..|..:.:.:....|:.||.:| ||     :.| ||.|..||
Mouse    69 TRELLWSW-AQKNKTIGDLLEVLQDMGHQRAIHLIINYGVS-----WTP-SVQTHHEL------- 119

  Fly   147 AKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTV------QRAAESLLEIDYAE 205
                   ||||..       ........|..|......|:.:..|      ::.......|.:..
Mouse   120 -------PFPSFP-------PEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQS 170

  Fly   206 LENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSY----NELKYL 266
            :...|..:..|..:|:|...:|||...:....|:|:..      .:|.::|::.:    :||:.|
Mouse   171 ILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFK------QEKKMQLKKHWKRFLSELEVL 229

  Fly   267 NSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGI 331
            ...||.:||.|..|..:..|.||||..|..|:|..||:......|   |:|..|.|:.:|.|:.|
Mouse   230 LLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTP---LSWHVRISVLIGIAKAI 291

  Fly   332 YFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTK---IYLPP 393
            .:||..:...:|.|::..||||||..||||:.||......|........:|...|.:   .|:|.
Mouse   292 QYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPE 356

  Fly   394 EFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAA 458
            |:....:||...||||||||::||.||.:|....|::...::||           |||:||
Mouse   357 EYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLL-----------MELMEK---- 406

  Fly   459 PMGKELDMCMCAIE-----------------AGLHCTALDPQDRPSMNAVLKRFE 496
               :.||.|:..::                 || .|.|...:.||:|:.||...|
Mouse   407 ---RGLDSCLSFLDRKIPPCPRNFSAKLFSLAG-RCVATKAKLRPTMDEVLSSLE 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_476971.1	Death_Pelle	32..128	CDD:260021	27/99 (27%)
		STKc_IRAK	219..498	CDD:270968	94/302 (31%)
Irak3	NP_082955.2	Death_IRAK-M	16..102	CDD:260062	22/86 (26%)
		PK_IRAK3	184..459	CDD:271062	94/302 (31%)