DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and irak3

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_017210784.1	Gene:	irak3 / 567444	ZFINID:	ZDB-GENE-060503-710	Length:	630	Species:	Danio rerio

Alignment Length:	501	Identity:	142/501 - (28%)
Similarity:	224/501 - (44%)	Gaps:	87/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TRSRSHLDNTMAIRLL---PLPVRAQLCAHLDA-LD--VWQQLATAVKLYPDQVEQISSQKQRGR 80
            ||:.|  .||....||   |..:....|..:|: :|  .|:.||:.:.....:|..|......|:
Zfish    14 TRNMS--GNTEPSTLLFDVPPVLMESFCRLMDSGVDGLGWRTLASRILSSQLEVRCIEMYAVAGK 76

  Fly    81 SASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDS 145
            |.:.|.:..| .|.|.||:.|..:..::....|..|.:                       :.||
Zfish    77 SPTKELMWSW-AQRNKTVEDLLKVLDEMGHARARSLFQ-----------------------SQDS 117

  Fly   146 SAKVNNGPP-FPS---SSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAE-SLLEIDYAE 205
            ....::.|| :|:   |:|.|.                  .:.::|..:|....| ....|.|.:
Zfish   118 CVLKSSSPPHYPTYLRSTGKSC------------------QVSDLHAESVSVEGEKQKCFITYFD 164

  Fly   206 LENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIR 270
            :...|..:..|.::|..||.:||.|:|.....|:||  ::..|........::...|::.|...:
Zfish   165 VIEGTRHFHQDLKIGGSGFAEVYCGRWGNRSFAVKV--FKQENKTDWKALWEKFTKEIEVLQLNQ 227

  Fly   271 HDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLH 335
            |.|||.|:|......:.||||..::.|||..||..| ...|   |:||:|.:|..|||:.::.||
Zfish   228 HPNILELWGSFSDSDRFCLVYPFLQNGSLFHRLHEH-VDKP---LSWQERLNIIKGTAKAVHHLH 288

  Fly   336 TARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLD--AVVEVNKVFGTKI-YLPPEFRN 397
            |::...:|.|:|..:|||||:.:|||:.||||.|..|.|:|  ..:.:|....:.: |||.|:..
Zfish   289 TSQPCTVICGNITSSNILLDENMQPKLCDFGLARLRPHSVDQSCTIVMNTALHSNLGYLPEEYIR 353

  Fly   398 FRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLL--DYVKQQWRQNRMELLEKHLAAPM 460
            ..:||..:||||.|:|:||..||::|     :.|:.|||.  |.:       ..|:.||......
Zfish   354 DGKLSVKLDVYSLGVVILETCTGQKV-----KQESSKNLFLRDVL-------HSEVEEKGCVDAC 406

  Fly   461 GKELDM---------CMCAIEAGLHCTALDPQDRPSMNAVLKRFEP 497
            .:.||:         .:|.:..||.||....:.||.|..||:|..|
Zfish   407 LRFLDLKFEHWPPAVALCLLRLGLECTGSKMRVRPDMEMVLQRLIP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	22/101 (22%)
		STKc_IRAK	219..498	CDD:270968	100/293 (34%)
		TyrKc	219..495	CDD:197581	98/289 (34%)
irak3	XP_017210784.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588112
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4080
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25527
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.900