DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and IRAK2

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001561.3	Gene:	IRAK2 / 3656	HGNCID:	6113	Length:	625	Species:	Homo sapiens

Alignment Length:	515	Identity:	140/515 - (27%)
Similarity:	227/515 - (44%)	Gaps:	99/515 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MAIRLLPLP--VRAQLCAHLDALDVWQQLATAVKLYPD--QVEQISS-QKQRGRSASNEFLNIWG 91
            ||..:..||  |...||.::|||..|..:..|..:..|  |:.:|.| ::.:|.|.:.|.| .|.
Human     1 MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELL-WWW 64

  Fly    92 GQYNHTVQTLFALFKKLKLHNAMRLIKDY-VSEDLHKYIPR---SV----PTISELRAA------ 142
            |....|||.|..|..:|:|:.|.::|.:: .:.::...||.   ||    |..:.:|.|
Human    65 GMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEE 129

  Fly   143 -----------PDSSAKVNNGPPF--------PSS--SGVSNSNNNRTSTTATEEIPSLESLGNI 186
                       |.||....:.|.|        |.|  |.:..|::::..:|:   ||..|.|
Human   130 GQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTS---IPKQEKL--- 188

  Fly   187 HISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQ 251
                :..|.:||...: |::..|||.::.:.::.||.|.|||||.           .:..|.:.:
Human   189 ----LSLAGDSLFWSE-ADVVQATDDFNQNRKISQGTFADVYRGH-----------RHGKPFVFK 237

  Fly   252 KMVE--------LQQSYN-ELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHK 307
            |:.|        :::.:. ||:......|.|:|.:.|:.........:|..|..|||:.||:...
Human   238 KLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQG 302

  Fly   308 AQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGD--FGLVRE 370
            ..:|||   |.||.||..|....:.:||   |..:||.::|.:|:||||.|.||:..  ..|...
Human   303 GSDPLP---WPQRVSICSGLLCAVEYLH---GLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPV 361

  Fly   371 GPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKN 435
            ..:|...:::.:.:..:..|||.:|....||:..||::|.||||.||.||....|   .|.:...
Human   362 NKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMD---NNRSPVY 423

  Fly   436 LLDYV-------------KQQWRQNRM--ELLEKHLAAPMGKELDMCMCAIEAGLHCTAL 480
            |.|.:             ::...:|.|  |:.:|:|....|:..:.|..|: |...|..|
Human   424 LKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEAL-ATAACLCL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	31/101 (31%)
		STKc_IRAK	219..498	CDD:270968	81/288 (28%)
		TyrKc	219..495	CDD:197581	81/288 (28%)
IRAK2	NP_001561.3	Death_IRAK2	3..91	CDD:176773	28/88 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..181		12/69 (17%)
		STKc_IRAK2	216..504	CDD:271059	81/288 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4233
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41104
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.900