DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and Irak2

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001020593.1	Gene:	Irak2 / 362418	RGDID:	1309584	Length:	624	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	141/527 - (26%)
Similarity:	221/527 - (41%)	Gaps:	95/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MAIRLLPLP--VRAQLCAHLDALDVWQQLATAVKLYPD--QVEQISS-QKQRGRSASNEFLNIWG 91
            ||..:..||  |...||.::|.|..|..:..|..:..|  |:.:|.| ::.:|.|.:.|.| .|.
  Rat     1 MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRKIKSMERVQGVSITRELL-WWW 64

  Fly    92 GQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPFP 156
            .....|||.|..|...|:|:.|.:::..:      |..|.|   :|.|.|.|::   |..||...
  Rat    65 SMRQATVQQLVDLLCHLELYRAAQIVLSW------KPAPDS---LSPLSAFPEA---VKPGPVAT 117

  Fly   157 S--------------------SSGVSNSNNNRTST---TATEEIP-SL-----ESLGNIHISTVQ 192
            |                    |||.:.:...:.::   ...|:.| ||     :||.:.:.||..
  Rat   118 SGRNLKDDQKKGQPVKPCSFLSSGTTMAGAQQQASCQRPCEEDAPCSLKTDVPDSLQSKYCSTSI 182

  Fly   193 RAAESLLEI-------DYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNID 250
            ...|.||.:       ..|::..||:.:...:|:.:|.|.|:|||:...:..|.|.:...:.:..
  Rat   183 PKQEKLLNLPGDRLFWSEADIVQATEDFDQSHRISEGTFADIYRGQRNGVAFAFKRLREVTGSSP 247

  Fly   251 QKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPAL 315
            ..|....|:  |::......|.|||.|.|:........|:|..|..|||:.||   .||.....|
  Rat   248 GSMDRFLQA--EMQLCLRCCHPNILPLLGFCTGRQFHSLIYPYMANGSLQDRL---WAQGDSDML 307

  Fly   316 TWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGP---KSLDA 377
            :|.||.||..|....:..||:   ..:||.::|.||:||||.|.||:. ..:....|   |:...
  Rat   308 SWPQRASICSGLLLAVEHLHS---LDIIHSNVKSANVLLDQHLNPKLA-HPVAHPCPTNKKTKYT 368

  Fly   378 VVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDR--------------VP 428
            |::.:....:..|||..|....||:..||::|.||||.||.||....|:              :|
  Rat   369 VMKTHLFQASAAYLPENFIRVGQLTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIP 433

  Fly   429 ENETK---------KNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQD 484
            .|.:.         |.::..:.|:..:.:..||.:..|......:.:|:...||.|.      :.
  Rat   434 SNTSSVHSRKTSMGKVVVKEICQKHLERKAGLLPEACAETWATAVSVCLRRREASLE------EA 492

  Fly   485 RPSMNAV 491
            |.||..|
  Rat   493 RVSMAGV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	28/100 (28%)
		STKc_IRAK	219..498	CDD:270968	84/299 (28%)
		TyrKc	219..495	CDD:197581	84/299 (28%)
Irak2	NP_001020593.1	Death_IRAK2	3..91	CDD:176773	26/88 (30%)
		PKc_like	216..504	CDD:419665	84/299 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..536
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850