DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pll and Ripk3

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_647558.2	Gene:	Ripk3 / 246240	RGDID:	628899	Length:	478	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	100/317 - (31%)
Similarity:	144/317 - (45%)	Gaps:	74/317 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 AESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGK---WKQLDVAIKVMNYRSPNIDQKMVEL 256
            |.|:..:...||||.  |:     :|:||||.|:|.:   | .||||:|::|  |..|.:
  Rat    11 ASSISLVGSEELENL--GF-----VGKGGFGAVFRARHTAW-NLDVAVKIVN--SKKISR----- 60

  Fly   257 QQSYNELKYLNSIRHDNILALYGYS-------IKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPA 314
                 |:|.:.::||:|:|.|.|.:       :.|  |.||...|:.|||...|   :...|.|
  Rat    61 -----EVKAMVNLRHENVLLLLGVTENLEWDYVYG--PALVTGFMENGSLSGLL---QPSCPRP- 114

  Fly   315 LTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVR--------EG 371
              |.....:......|:.:||:...: |:|.|:||:|:|||..|..|:.||||..        .|
  Rat   115 --WPLLCRLLEEVVLGMCYLHSLNPS-LLHRDLKPSNVLLDPELHAKLADFGLSTFQGGSQSGSG 176

  Fly   372 PKSLDAVVEVNKVFGTKIYLPPE-FRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKN 435
            ..|.|:       .||..||.|| ..|..:.|...||||||:::..|..||:.     |...|.:
  Rat   177 SGSRDS-------GGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREA-----EVVDKTS 229

  Fly   436 LLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGL-----HCTALDPQDRPS 487
            |:...... ||.|..|.|....:|....|:        ||     ||.:.:|:||||
  Rat   230 LIRGAVCN-RQRRPPLTELPPDSPETPGLE--------GLKELMTHCWSSEPKDRPS 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021
		STKc_IRAK	219..498	CDD:270968	93/293 (32%)
		TyrKc	219..495	CDD:197581	93/293 (32%)
Ripk3	NP_647558.2	PKc_like	28..285	CDD:419665	93/293 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..429
		RHIM	408..458	CDD:403811
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250\|UniProtKB:Q9Y572	437..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000