Protein Alignment pll and Irak1

DIOPT Version :10

• Sequence 1: NP_476971.1
• Gene: pll / 43283
• FlyBaseID: FBgn0010441
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001171444.1
• Gene: Irak1 / 16179
• MGIID: 107420
• Length: 750
• Species: Mus musculus
• Alignment Length: 485
• Identity: 144/485 - (29%)
• Similarity: 214/485 - (44%)
• Gaps: 80/485 - (16%)

  Fly    49 LDALDV--WQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLH 111
            :|||:.  |.|.|..:  ..||.|....::...|:||  .|..|..: |..|..|..:...|:|.
Mouse    34 MDALEPADWCQFAALI--VRDQTELRLCERSEQRTAS--VLWPWINR-NARVADLVHILTHLQLL 93

  Fly   112 NAMRLIKDY--------------------VSEDLHKYIPRSVPTI-----------------SEL 139
            .|..:|..:                    ...:...:.||.:.:.                 |||
Mouse    94 RARDIITAWHPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESEL 158

  Fly   140 RAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYA 204
            ...|   ..|:.|||.|||:..|...::..|.                :|.:|||..|.....:.
Mouse   159 LQVP---LPVSLGPPLPSSAPSSTKQSSPESP----------------VSGLQRAHPSPFCWPFC 204

  Fly   205 ELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSY-NELKYLNS 268
            |:...|..:|.:.|:|:||||.|||...:....|:|.:...:   |.:...::||: .|::.|:.
Mouse   205 EISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEA---DLEWTMVKQSFLTEVEQLSR 266

  Fly   269 IRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYF 333
            .||.||:...||..:.|..||||..:..||||.:|  |........|:|.||..|.|||||.|.|
Mouse   267 FRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQL--HLQTQACSPLSWPQRLDILLGTARAIQF 329

  Fly   334 LHTARGTP-LIHGDIKPANILLDQCLQPKIGDFGLVR----EGPKSLDA--VVEVNKVFGTKIYL 391
            ||  :.:| |||||||.:|:|||:.|.||:|||||.|    .|.|:..:  |...:.|.||..||
Mouse   330 LH--QDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYL 392

  Fly   392 PPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHL 456
            |.|:....:|:...|.:|||:|:||...|::.. |....:| |.|.|.::.:..:..:.|.....
Mouse   393 PEEYIKTGRLAVDTDTFSFGVVILETLAGQRAV-RTQGAKT-KYLKDLIEDEAEEAGVTLKSTQP 455

  Fly   457 AAPMGKELDMCMCAIEAGLHCTALDPQDRP 486
            ...:|...|.....|.|.::...||.:..|
Mouse   456 TLWVGVATDAWAAPIAAQIYKKHLDSRPGP 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_476971.1	Death_Pelle	32..128	CDD:260021	21/100 (21%)
		STKc_IRAK	219..498	CDD:270968	99/276 (36%)
Irak1	NP_001171444.1	Death_IRAK1	17..100	CDD:260061	20/70 (29%)
		Protein Kinases, catalytic domain	219..514	CDD:473864	99/276 (36%)