DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pll and Irak1

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001171444.1	Gene:	Irak1 / 16179	MGIID:	107420	Length:	750	Species:	Mus musculus

Alignment Length:	485	Identity:	144/485 - (29%)
Similarity:	214/485 - (44%)	Gaps:	80/485 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LDALDV--WQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLH 111
            :|||:.  |.|.|..:  ..||.|....::...|:||  .|..|..: |..|..|..:...|:|.
Mouse    34 MDALEPADWCQFAALI--VRDQTELRLCERSEQRTAS--VLWPWINR-NARVADLVHILTHLQLL 93

  Fly   112 NAMRLIKDY--------------------VSEDLHKYIPRSVPTI-----------------SEL 139
            .|..:|..:                    ...:...:.||.:.:.                 |||
Mouse    94 RARDIITAWHPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESEL 158

  Fly   140 RAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYA 204
            ...|   ..|:.|||.|||:..|...::..|.                :|.:|||..|.....:.
Mouse   159 LQVP---LPVSLGPPLPSSAPSSTKQSSPESP----------------VSGLQRAHPSPFCWPFC 204

  Fly   205 ELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSY-NELKYLNS 268
            |:...|..:|.:.|:|:||||.|||...:....|:|.:...:   |.:...::||: .|::.|:.
Mouse   205 EISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEA---DLEWTMVKQSFLTEVEQLSR 266

  Fly   269 IRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYF 333
            .||.||:...||..:.|..||||..:..||||.:|  |........|:|.||..|.|||||.|.|
Mouse   267 FRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQL--HLQTQACSPLSWPQRLDILLGTARAIQF 329

  Fly   334 LHTARGTP-LIHGDIKPANILLDQCLQPKIGDFGLVR----EGPKSLDA--VVEVNKVFGTKIYL 391
            ||  :.:| |||||||.:|:|||:.|.||:|||||.|    .|.|:..:  |...:.|.||..||
Mouse   330 LH--QDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYL 392

  Fly   392 PPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHL 456
            |.|:....:|:...|.:|||:|:||...|::.. |....:| |.|.|.::.:..:..:.|.....
Mouse   393 PEEYIKTGRLAVDTDTFSFGVVILETLAGQRAV-RTQGAKT-KYLKDLIEDEAEEAGVTLKSTQP 455

  Fly   457 AAPMGKELDMCMCAIEAGLHCTALDPQDRP 486
            ...:|...|.....|.|.::...||.:..|
Mouse   456 TLWVGVATDAWAAPIAAQIYKKHLDSRPGP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	21/100 (21%)
		STKc_IRAK	219..498	CDD:270968	99/276 (36%)
		TyrKc	219..495	CDD:197581	99/276 (36%)
Irak1	NP_001171444.1	Death_IRAK1	17..100	CDD:260061	20/70 (29%)
		STYKc	219..514	CDD:214568	99/276 (36%)
		PKc_like	219..514	CDD:304357	99/276 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843178
Domainoid	1	1.000	144	1.000	Domainoid score	I4588
eggNOG	1	0.900	-	-		E33208_3BCM7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43176
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3098
SonicParanoid	1	1.000	-	-		X7172
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780