DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and IRAK3

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_009130.2	Gene:	IRAK3 / 11213	HGNCID:	17020	Length:	596	Species:	Homo sapiens

Alignment Length:	490	Identity:	130/490 - (26%)
Similarity:	206/490 - (42%)	Gaps:	95/490 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LPLPVRAQLCAHLDALD---VWQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTV 98
            ||..:..:|||.||:.|   .|:.||..:......|..|.....:|:|.:.|.|..| .|.|.|:
Human    20 LPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSW-AQKNKTI 83

  Fly    99 QTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPP---FPSSSG 160
            ..|..:.:::....|:.||.:|.:.                 .:|...:....|.|   |..::.
Human    84 GDLLQVLQEMGHRRAIHLITNYGAV-----------------LSPSEKSYQEGGFPNILFKETAN 131

  Fly   161 VSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFG 225
            |:..|         ..||.....|.:..|:          |.:..:...|..:..|..:|:|...
Human   132 VTVDN---------VLIPEHNEKGILLKSS----------ISFQNIIEGTRNFHKDFLIGEGEIF 177

  Fly   226 DVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSY----NELKYLNSIRHDNILALYGYSIKGGK 286
            :|||.:.:.|..|:|:..      .:|.::.::.:    :||:.|....|.|||.|..|..:..|
Human   178 EVYRVEIQNLTYAVKLFK------QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEK 236

  Fly   287 PCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPAN 351
            .||:|..|:.|:|..||:......|||   |..|..|.:|.::.|::||..:...:|.|.|..||
Human   237 FCLIYPYMRNGTLFDRLQCVGDTAPLP---WHIRIGILIGISKAIHYLHNVQPCSVICGSISSAN 298

  Fly   352 ILLDQCLQPKIGDFGLV--REGPKSLDAVVEVNKVFGTKI-YLPPEFRNFRQLSTGVDVYSFGIV 413
            ||||...|||:.||.:.  |...:.....:.:.......: |:|.|:....:||...||||||||
Human   299 ILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIV 363

  Fly   414 LLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIE------ 472
            ::||.||.:|....|::...::||           .||:||       :.||.|:..::
Human   364 IMEVLTGCRVVLDDPKHIQLRDLL-----------RELMEK-------RGLDSCLSFLDKKVPPC 410

  Fly   473 -----------AGLHCTALDPQDRPSMNAVLKRFE 496
                       || .|.|...:.||||:.||...|
Human   411 PRNFSAKLFCLAG-RCAATRAKLRPSMDEVLNTLE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	26/93 (28%)
		STKc_IRAK	219..498	CDD:270968	91/302 (30%)
		TyrKc	219..495	CDD:197581	90/299 (30%)
IRAK3	NP_009130.2	TyrKc	171..443	CDD:197581	90/299 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..596
		Death_IRAK-M	15..103	CDD:260062	24/83 (29%)
		PK_IRAK3	171..446	CDD:271062	91/302 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41104
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850