DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and TTLL7

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001337143.1	Gene:	TTLL7 / 79739	HGNCID:	26242	Length:	887	Species:	Homo sapiens

Alignment Length:	628	Identity:	210/628 - (33%)
Similarity:	343/628 - (54%)	Gaps:	76/628 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 MPA--EEAKLQGFIQLNNKTYRVECPTRVLNPPMNVDEERPASET----------KSTIC--VSN 152
            ||:  :|..:||             |:     |::::.|.|...|          |.||.  |:.
Human     1 MPSLPQEGVIQG-------------PS-----PLDLNTELPYQSTMKRKVRKKKKKGTITANVAG 47

  Fly   153 SRYAMIGKISKTLGY-KLVKESKMWNILWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSR 216
            :::.::..:...:|: |...|.:..|::|.||....|....::.:|:|||||||.||||||.|:|
Human    48 TKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLAR 112

  Fly   217 NLNRMLKIFPQDYKIFPKTWMLPADYGDAMNYA--LNHKR---TFILKPDSGAQGRGIWLTNDLK 276
            |:.:|:|..|.||...|:||:.||:|....||.  |..||   |||:||.:||.|.||.|..:..
Human   113 NMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGD 177

  Fly   277 TIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNAN 341
            .:...:.||.|.||.:|.|::|||||||:|.|:||.|||:||:|::||.|..|.||:.|...|..
Human   178 KLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLT 242

  Fly   342 DLYMHLTNYSVNKRNSHYELCDNDDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAW 406
            .||||||||||||.|.|:|..:.::.||||.:.....:::.:.:||.:|||::.::::||::.|.
Human   243 QLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAE 307

  Fly   407 PVLKHNYHACFPGH--DKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIR 469
            |.:.|.|..|.||.  .....|||:||||||:|.||||::||:|.:|||.|::::|.:|||.::.
Human   308 PHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLL 372

  Fly   470 DTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTS-----KPKIDAQKGSPDA 529
            :.|.|::...:|||:.|.:.:...::||.   |...::  ||..|:|     :.:::.:|
Human   373 NALKLLNIRTSDKRRNLAKQKAEAQRRLY---GQNSIK--RLLPGSSDWEQQRHQLERRK----- 427

  Fly   530 QPVDVEPEAEDHGPLAQQIAWEE---SHLGNFRKIMPPPDLSKLDYYTRFYAQSHQVSIFAETAA 591
                 |...|....:.:||:.||   .|:||:|:|.||.|.:.|:.|....|.:.| :..:..||
Human   428 -----EELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQ-TFLSGRAA 486

  Fly   592 SKKRE--DLARKMR----IQLEEKKAKQQQMLNGKAKRDARKRHTVLLPRAVREKNRINFFRLRE 650
            |.:||  :..::|:    :.|.|:.....:.|.||..:....:....:|.:.....|..:.....
Human   487 SFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDS 551

  Fly   651 NW-SPGFISDAEERLRHTWLHMRAEAIRTLKITENIY-SNLYE 691
            :: |....|:::|..:..:.:.:.|.    ::|.|:. ||.|:
Human   552 SYDSSSSSSESDENEKEEYQNKKREK----QVTYNLKPSNHYK 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	139/296 (47%)
TTLL7	NP_001337143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		7/37 (19%)
		TTL	91..376	CDD:281171	134/284 (47%)
		SMC_N	<373..>518	CDD:330553	40/160 (25%)
		DUF2570	<383..>448	CDD:329230	18/79 (23%)
		c-MTBD region. /evidence=ECO:0000269\|PubMed:25959773	388..450		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..621		13/76 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251554at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5342
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850