DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and Ttll7

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001289886.1	Gene:	Ttll7 / 70892	MGIID:	1918142	Length:	912	Species:	Mus musculus

Alignment Length:	548	Identity:	193/548 - (35%)
Similarity:	308/548 - (56%)	Gaps:	48/548 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PMNVDEERPASETKS------------TICVSNSRYAMIGKISKTLGY-KLVKESKMWNILWSDS 183
            |:::..|.|...|..            |..|:.:::.::..:...:|: |...|.:..|::|.|:
Mouse    15 PVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDA 79

  Fly   184 FPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQDYKIFPKTWMLPADYGDAMNY 248
            ....|...:::.:|:|||||||.||||||.|:||:.:|:|..|.||...|:||:.|::|....||
Mouse    80 AVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNY 144

  Fly   249 A--LNHKR---TFILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTL 308
            .  |..||   |||:||.:||.|.||.|..:...:...:.||.|.||.:|.|::|||||||:|.|
Mouse   145 VKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYIL 209

  Fly   309 ITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDNDDCGSKRKL 373
            :||.|||:||:|::||.|..|.||:.|...|...||||||||||||.|..:|..:.:|.||||.:
Mouse   210 VTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSI 274

  Fly   374 SAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLKHNYHACFPGH--DKIQACFEILGFDILV 436
            .....:::.:.:||.:|||::.::::||::.|.|.:.|.|..|.||.  .....|||:||||||:
Mouse   275 KWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILL 339

  Fly   437 DWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIR 501
            |.||||::||:|.:|||.|::::|.:|||.::.:.|.|::...:|||:.|.:.:...::||.
Mouse   340 DRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLY--- 401

  Fly   502 GDPPVQRPRLGGGTS-----KPKIDAQKGSPDAQPVDVEPEA--EDHGPLAQQIAWEESHLGNFR 559
            |..||:  ||..|:|     :.:::.:|.....:.:.|..:.  |:|         |..|:||:|
Mouse   402 GQNPVR--RLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEH---------ENRHMGNYR 455

  Fly   560 KIMPPPDLSKLDYYTRFYAQSHQVSIFAETAASKKRE--DLARKMR----IQLEEKKAKQQQMLN 618
            :|.||.|.:.|:.|....|.:.| :..:..|||.:||  :..:|||    :.|.|:.....:.|.
Mouse   456 RIYPPEDKALLEKYEGLLAVAFQ-TFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLM 519

  Fly   619 GKAKRDARKRHTVLLPRAVREKNRINFF 646
            ||..|....:....:|.......:..::
Mouse   520 GKTGRVRGPKPLCCMPECAEVTKKQKYY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	138/296 (47%)
Ttll7	NP_001289886.1	TTL	91..376	CDD:281171	133/284 (47%)
		c-MTBD region. /evidence=ECO:0000250\|UniProtKB:Q6ZT98	388..450		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..570		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..688
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251554at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5342
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950