DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL6B and Ttll4

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_001074653.1	Gene:	Ttll4 / 690512	RGDID:	1594742	Length:	1198	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	158/491 - (32%)
Similarity:	239/491 - (48%)	Gaps:	89/491 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 ISKTLG---YKLVKESKMWNILWSDSF--PGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNR 220
            :.:|:|   :|:.|.:..|...|....  ||   |::::..|::|||||..:|.|||.|.|||:|
  Rat   617 VKQTIGRSHFKISKRNDDWLGCWGHHMKSPG---FRSIREHQKLNHFPGSFQIGRKDRLWRNLSR 678

  Fly   221 MLKIF-PQDYKIFPKTWMLPADYGDAMNYA--LNHKRTFILKPDSGAQGRGIWLTNDLKTIGPHE 282
            |...| .:::..||::::||.| ...:..|  .:.::.:|:||.:.|:|.||.:.:....:....
  Rat   679 MQSRFGKKEFSFFPQSFILPQD-SKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRR 742

  Fly   283 RLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHL 347
            .|:.|.|:|:|.||.|.|||||:|..:||.|||||:::::||.|||:.|| .|:..:.::.:|||
  Rat   743 PLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKY-SPSMKSLSNKFMHL 806

  Fly   348 TNYSVNKRNSHYEL-CDNDDC-GSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLK 410
            |||||||:|:.|:. .|...| |.|..|.|:.|::.:...:.:..|..:.||::||::|:.|.:.
  Rat   807 TNYSVNKKNAEYQANADETACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVT 871

  Fly   411 H--NYHACFPGHDKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLN 473
            :  ..:...|     .:|.|:.||||::|..|||::||||.|||.|:|..:|..:|..:|||.||
  Rat   872 NLLKLYVRRP-----YSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRDLLN 931

  Fly   474 LVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTSKPK------------IDAQKGS 526
            |...||.:...||..........               |..||.|.            ..|||..
  Rat   932 LAGFVLPNMEDILSSSSSPSSSS---------------GSSTSLPSSPREKCQMTPEHFTAQKMK 981

  Fly   527 ---------PDAQ----------PVDVE--PEAEDHGPLAQQIAWEESHLGNFRKIMPPPDLSKL 570
                     ||..          |.||.  .|.||          |.|..|.|.:|.|....|:
  Rat   982 KAYYLTQKVPDQDFYSSVLDVLTPDDVRVLVEMED----------EFSRRGQFERIFPSRISSR- 1035

  Fly   571 DYYTRFYAQSHQVSIFAETAASK------KREDLAR 600
              |.||:.|....:|.......|      |..||.|
  Rat  1036 --YLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLR 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	115/296 (39%)
Ttll4	XP_001074653.1	TTL	652..944	CDD:397308	115/298 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920