Protein Alignment TTLL6B and TTLL13

DIOPT Version :10

• Sequence 1: NP_651549.1
• Gene: TTLL6B / 43282
• FlyBaseID: FBgn0039501
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001382946.1
• Gene: TTLL13 / 440307
• HGNCID: 32484
• Length: 751
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 267/644 - (41%)
• Similarity: 367/644 - (56%)
• Gaps: 83/644 - (12%)

  Fly    73 RCLKRRTA----ADKQVDDNSPYYGPSSGENSPMPAEEAKLQGFIQLNNKTYRVECPTRVLNPPM 133
            :|:|....    :.:|....:.|....:|..||:.|                 .:.|.:|:.|..
Human    23 KCVKEGVTNPSNSSQQALLKADYKALKNGVPSPIMA-----------------TKIPKKVIAPVD 70

  Fly   134 NVDEE-----RPASETKSTICVSNSRYAMIGKISKTLGYKLVKESKMWNILWSDSFPGVELFKNM 193
            ..|.|     |........|.::|.:|..:.:.::..|.|.|.|.:.|.:.|:|....:|...:|
Human    71 TGDLEAGRRKRRRKRRSLAINLTNCKYESVRRAAQMCGLKEVGEDEEWTLYWTDCAVSLERVMDM 135

  Fly   194 KRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQDYKIFPKTWMLPADYGDAMNYALNHK-RTFI 257
            ||||:|||||||.||||||||:||||||.|::|.:|.|||:||.|||||||..:|....| ||:|
Human   136 KRFQKINHFPGMTEICRKDLLARNLNRMYKLYPSEYNIFPRTWCLPADYGDFQSYGRQRKARTYI 200

  Fly   258 LKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNE 322
            .|||||.|||||::|.:.:.|.|.|.:|||.||.:||||||:|||:|||.||||.||||||.|.|
Human   201 CKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVLITSCDPLRIFTYEE 265

  Fly   323 GLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDNDDCGSKRKLSAINNWMRRHNYDV 387
            |||||||..|:||:..|.:::.||||||::||.|.::  ..:...|||||||.:|.|::.|:|:.
Human   266 GLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENF--VRDGAVGSKRKLSTLNIWLQEHSYNP 328

  Fly   388 EEFWSNVDDVIIKTVLSAWPVLKHNYHACFPGH--DKIQACFEILGFDILVDWKLKPYILEVNHS 450
            .|.|.:::|:||||::||..||:|||..|||.:  ....|||||||||||:|.||||::||||||
Human   329 GELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLNGGTCACFEILGFDILLDHKLKPWLLEVNHS 393

  Fly   451 PSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGT 515
            |||.|:..:|:|||..|:.|.:.||:....|||::::||::|||:||.:....|...|
Human   394 PSFTTDSCLDQEVKDALLCDAMTLVNLRGCDKRKVMEEDKRRVKERLFQCYRQPRESR------- 451

  Fly   516 SKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQIAWEESHLGNFRKIMPPPDLSKLDYYTRFYAQS 580
             |.|.::                 .|..:..|..:|:||||.:|:|.|.||..|   |.||:  .
Human   452 -KEKTES-----------------SHVAMLDQERYEDSHLGKYRRIYPGPDTEK---YARFF--K 493

  Fly   581 HQVSIFAETAASKKREDLARKMRIQLEEKKAKQ-QQMLNGKAKRDARKRH------TVLLPRAVR 638
            |..|:|.||||||.||:.||:   ||||.:.|| ||..:|..::.||.::      ....|||..
Human   494 HNGSLFQETAASKAREECARQ---QLEEIRLKQEQQETSGTKRQKARDQNQGESAGEKSRPRAGL 555

  Fly   639 EKNRINFFRLRENWS------------PGFISDAEERLRHTWLHMRAEAIRTLKITENI 685
            :....:......||.            |..|.:.||..|...|..|...||:|.|.|.:
Human   556 QSLSTHLAYRNRNWEKELLPGQLDTMRPQEIVEEEELERMKALLQRETLIRSLGIVEQL 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:397308	171/292 (59%)
TTLL13	NP_001382946.1	TTL	133..427	CDD:397308	173/295 (59%)
		HEC1	<425..615	CDD:444066	70/223 (31%)