DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and TTLL5

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001287520.1	Gene:	TTLL5 / 43015	FlyBaseID:	FBgn0051108	Length:	917	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	206/776 - (26%)
Similarity:	346/776 - (44%)	Gaps:	121/776 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KIRKDREKRTHVVRALDMALNEQ-PCLDREWFSPEQSPPLQPMSPR----RRMKKTRCLKRRTAA 81
            ||||...:::......|...||: |....:..:.|:....:|.|..    ...:|...||:....
  Fly    47 KIRKTLSEKSSAQVLTDTKDNEEKPVQSPQKLAEEEPTSSEPSSKEALSGSTQQKIFLLKKPQQC 111

  Fly    82 DK--QVDDNSPY------YG------PSSGENSPMPAEEAK------LQGFIQL-------NNKT 119
            ||  ::..:||:      |.      .|.|| .|..:.|.|      .|..|.:       |...
  Fly   112 DKSDKLTFSSPFKKILNRYSSSDTSISSEGE-EPANSSENKSRVLKTSQNAINIKLATDLSNESG 175

  Fly   120 YRVECPTRVLNPPMNVDEER--------------PASETKSTICVSNSRYAMIGKISKTLGYKLV 170
            |....|.:.::....::|::              |||:.|.|.....:...::.|:....|...|
  Fly   176 YESIAPAKTISNTEVIEEDQEETSEDDAECGINMPASKLKITYKFHQTETKLLRKLFNVHGLTEV 240

  Fly   171 K-ESKMWNILWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKI-FPQDYKIFP 233
            : |:..:|:||:.....:::.:|:..:|::||||...|:.|||.|.:|:.||..: ..:.:.|.|
  Fly   241 QGENNNFNLLWTGVHMKLDIVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVP 305

  Fly   234 KTWMLPADYGDAMNYALNHKRTFILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDG 298
            :|::||.:..|.:.....|:..:|:||.:.::||||::.|....|...|:.:...||..||.|||
  Fly   306 QTFVLPIESRDLVVAHNKHRGPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDG 370

  Fly   299 YKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLY---MHLTNYSVNKRNSHY- 359
            :|.|||||.|:||.|||.|::|.||:.|.||.||    ..:|::|:   |||.|||:||.:|.|
  Fly   371 HKCDLRVYVLVTSFDPLIIYLYEEGIVRLATVKY----DRHADNLWNPCMHLCNYSINKYHSDYI 431

  Fly   360 --ELCDNDDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLS-AWPVLKHNYHAC---FP 418
              ....::|.|.|..|||:...::..:.|..:...|::|:|||.||: |..::.    ||   .|
  Fly   432 RSSDAQDEDVGHKWTLSALLRHLKLQSCDTRQLMLNIEDLIIKAVLACAQSIIS----ACRMFVP 492

  Fly   419 GHDKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKR 483
            ..:.   |||:.|||||:|..|||::||:|.|||...:..:|.:||..|:.|.|..|......
  Fly   493 NGNN---CFELYGFDILIDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLLTCVGIPAYS-- 552

  Fly   484 QILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQI 548
               .|.:....|:..:.|.....:.......:.|.|...:||:    .:::....|:. .:.:..
  Fly   553 ---PEMKSHYDQKWSRFRSSSCQRIATFPSTSQKTKKSKKKGA----AINLNLTGEEQ-RILRNA 609

  Fly   549 AWEESHLGNFRKIMPPPDLSKLDYYTRFYAQSHQVSIFAETAASKK------REDLARKMRIQLE 607
            ..:.|..|.|.:|.|..|  .:..|..|...::.:.|......|:.      :.:..:.:...|.
  Fly   610 RLQYSRRGGFVRIFPTDD--SMQRYGNFLDSANGIPISTPNVQSQTFQTPIIQHNYNQMLHQNLY 672

  Fly   608 EKKAKQQQMLNGKAKR----------DAR----KRHTVLLPRAVREKNRINFFRLRENWSPGFIS 658
            .|..:|:|..|.:|.|          |:.    |:.||       ||..:...|||:..... ||
  Fly   673 SKDGRQKQDDNNEADRIWQYERALETDSEIPFVKKPTV-------EKCEVEGRRLRKIMLKK-IS 729

  Fly   659 DAEE----RLRHTWLHMRAEAIRTLKITENIYSNLYETGLLTNTD----MVVYPHLYHNLQ 711
            :..|    :.|.|:.......:|  ::||:...| :|..:|...:    .|..|.::.|:|
  Fly   730 NGSELTPFQARQTFSMYLESVLR--RLTEDPKDN-HEKIILKFLNKFGGSVKPPVMFRNMQ 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	113/300 (38%)
TTLL5	NP_001287520.1	TTL	266..549	CDD:281171	113/293 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450546
Domainoid	1	1.000	75	1.000	Domainoid score	I2480
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950