DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and Ttll5

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_006516052.1	Gene:	Ttll5 / 320244	MGIID:	2443657	Length:	1337	Species:	Mus musculus

Alignment Length:	543	Identity:	164/543 - (30%)
Similarity:	269/543 - (49%)	Gaps:	73/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 STICVSNSRYAMIGKISKTLGYKLVK-------------ESKMWNILWSDSFPGVELFKNMKRFQ 197
            :.|.|...||.:..||.:| ..:||:             .|..:|::|:.|.....|.:.:...|
Mouse    54 NNIRVIGERYHLSYKIVRT-DSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQ 117

  Fly   198 QINHFPGMIEICRKDLLSRNLNRM-----LKIFPQDYKIFPKTWMLPADYGDAMNYALNHKRTFI 257
            ::||||...|:.|||.|.:|:.||     .|.|    .|.|:|::|||:|.:..|.....:..:|
Mouse   118 KVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAF----HILPQTFLLPAEYAEFCNSYSKDRGPWI 178

  Fly   258 LKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNE 322
            :||.:.::|||::|.|:...|...|.::...||:.|||||.:|||:|:|.|:||.|||.|::|.|
Mouse   179 VKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEE 243

  Fly   323 GLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDN---DDCGSKRKLSAINNWMRRHN 384
            |||||||.:|.:.:. |..:.:||||||||||::..|..||:   :|.|:|..:||:..::::..
Mouse   244 GLARFATVRYDQGSK-NIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEG 307

  Fly   385 YDVEEFWSNVDDVIIKTVLSAWPVLKHNYHAC--FPGHDKIQACFEILGFDILVDWKLKPYILEV 447
            .|.....::|:|:||||::||...:.   .||  |..|.  .:|||:.|||:|:|..|||::|||
Mouse   308 KDTTALMAHVEDLIIKTIISAELAIA---TACKTFVPHR--SSCFELYGFDVLIDNTLKPWLLEV 367

  Fly   448 NHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLG 512
            |.|||...:..:|.::|..:|.|...:|..|..|..|  :...:.:.......|.:|
Mouse   368 NLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQ--RTSNRSIYPSFESSRRNP-------- 422

  Fly   513 GGTSKPKIDAQKGSPDAQPVDVEPEAEDHGP----------------LAQQIAWEESHLGNFRKI 561
              ..||:......:.||:..::...|.:..|                :.:::..|....|.|.:|
Mouse   423 --FQKPQRTRPLSASDAEMKNLVASAREKVPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRI 485

  Fly   562 MPPPDLSKLDYYTRFYAQSHQVSI-------FAETAASKKREDLARKMRIQLEEKKAKQQQMLNG 619
            .|..:..::  |..:.  .|:.|:       ..:...:.:|..|..:.|:..|.....:.:.:|.
Mouse   486 FPTSETWEI--YGSYL--EHKTSMNYMLATRLFQDRGNPRRSLLTGRARVSTEGAPELKVESMNS 546

  Fly   620 KAKRDARKRHTVLLPRAVREKNR 642
            |||..|......||...||::.|
Mouse   547 KAKLHAALYERKLLSLEVRKRRR 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	120/299 (40%)
Ttll5	XP_006516052.1	TTL	117..395	CDD:397308	116/287 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920