DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and Ttll13

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001128434.1	Gene:	Ttll13 / 308762	RGDID:	1310399	Length:	825	Species:	Rattus norvegicus

Alignment Length:	649	Identity:	270/649 - (41%)
Similarity:	371/649 - (57%)	Gaps:	77/649 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PSSGENSPMPAEEAKLQGFIQLNNKTYRVECPTRVLNPPMNVDEE-----RPASETKSTICVSNS 153
            |:|.:.:...|:..:.:..:.|:.....:  |.::|:.....|.|     |........|.::|.
  Rat    33 PNSSQQALGKADYKEFENGVALSVVAKNI--PKKILSTTDTDDLEVGRRKRKRKRRPLAINLTNC 95

  Fly   154 RYAMIGKISKTLGYKLVKESKMWNILWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNL 218
            :|..:.:.::..|.|.|.|.:.|.:.|:|....:|...:|||||:|||||||.||||||||:|||
  Rat    96 KYESVRRAAQMCGLKEVGEDEEWTVYWTDCSVSLERVMDMKRFQKINHFPGMTEICRKDLLARNL 160

  Fly   219 NRMLKIFPQDYKIFPKTWMLPADYGDAMNYALNHK-RTFILKPDSGAQGRGIWLTNDLKTIGPHE 282
            |||.|::|.:|.|||:||.|||||||...|....| ||:|.|||||.|||||::|...|.|.|.|
  Rat   161 NRMQKLYPTEYNIFPRTWCLPADYGDFQAYGRQRKTRTYICKPDSGCQGRGIFITRTPKEIKPGE 225

  Fly   283 RLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHL 347
            .:|||.||.:|.||||:|||:|:|.||||.||||||:|.||||||||..||||:..|..::.|||
  Rat   226 HMICQQYITKPFLIDGFKFDMRIYVLITSCDPLRIFMYEEGLARFATMPYVEPSHNNLEEVCMHL 290

  Fly   348 TNYSVNKRNSHYELCDNDDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLKHN 412
            |||::||.|.::  ..:|..|||||||.:|.|:|.|::|..|.|.:::|:||||::||..||:||
  Rat   291 TNYAINKHNENF--VRDDAVGSKRKLSTLNAWLREHSHDPRELWGDIEDIIIKTIISAHSVLRHN 353

  Fly   413 YHACFPGH--DKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLV 475
            |..|||.:  ....|||||||||||:|.||||::|||||||||.|:.::|||||..|:.|.:||:
  Rat   354 YRTCFPQYLCGGTCACFEILGFDILLDHKLKPWLLEVNHSPSFTTDSRLDREVKDALLCDAMNLI 418

  Fly   476 STVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAED 540
            :....||:::::|:::|||:||.     |..|:||          :|::          |.....
  Rat   419 NLRGCDKKKVIEEEKRRVKERLF-----PCHQQPR----------EARR----------EQLESS 458

  Fly   541 HGPLAQQIAWEESHLGNFRKIMPPPDLSKLDYYTRFYAQSHQVSIFAETAASKKREDLARKMRIQ 605
            ...:..|..:|:||||.:|:|.|.||..|   |..|:  .|..|:|.||||||.||:.||:   |
  Rat   459 QAAMHDQELYEDSHLGGYRRIYPGPDSEK---YAPFF--KHNGSLFQETAASKAREECARQ---Q 515

  Fly   606 LEEKKAKQQQMLN-GKAKRDARKRH---------------TVLLPRAVREKNRINFFRL----RE 650
            |||.:.||:|..| |..||...|..               |.:|...:..:||.....|    .:
  Rat   516 LEEIRLKQEQQENPGTKKRKENKEQNQGESAGEKSRSRVATRVLATNLAYRNRNQEKELLPVQLD 580

  Fly   651 NWSPGFISDAEERLRHTWLHMRAEAIRTLKITENIYSNLYETGLLTNTDMVVYPHLYHNLQHGY 714
            ...|..|.:.||..|...|..|...||:|.|.|.:...||.:            |..|...|.|
  Rat   581 TMQPQDIVEEEELERMKLLLQRENLIRSLGIVEQLTRMLYPS------------HRSHRKLHEY 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	173/292 (59%)
Ttll13	NP_001128434.1	TTL	133..416	CDD:281171	172/284 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I872
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251554at2759
OrthoFinder	1	1.000	-	-		FOG0005255
OrthoInspector	1	1.000	-	-		mtm9144
orthoMCL	1	0.900	-	-		OOG6_102355
Panther	1	1.100	-	-	LDO	PTHR12241
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3776
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970