DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and Ttll2

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_006227981.1	Gene:	Ttll2 / 292311	RGDID:	1305200	Length:	541	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	150/529 - (28%)
Similarity:	240/529 - (45%)	Gaps:	90/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 MNVDEERPASETKSTIC-VSNSRYAMIGKISKTLGYKLVKES----KMWNILW-SDSFPGVELFK 191
            :.:::|.|.:..|..:. |..|...::..:....|:....|.    :.||:.| |.||...| :.
  Rat    31 LRMEDEAPGAALKPLVFRVDESTPGVVQSVLLERGWDKFDEQCQDVEDWNLYWRSSSFRMAE-YV 94

  Fly   192 NMKRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQD-YKIFPKTWMLPADYGDAMNYALNHKRT 255
            |:|.:|::||.||...:.|||.|:::|..|.:::.:. |:..|.|:::|:||...:......|:.
  Rat    95 NIKPWQRLNHHPGTTSLTRKDCLAKHLAHMRRLYGESIYEFTPLTFIMPSDYTKFVAKYFKEKQD 159

  Fly   256 -------FILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVD 313
                   :|.||...:|||||.:.:|::.:...:..:.|.||..|||:..||.|||:|..:|...
  Rat   160 LGTKPSYWICKPAKLSQGRGIIIFSDIRDLMFKDAYVVQKYICNPLLVGRYKCDLRIYVCVTGFK 224

  Fly   314 PLRIFVYNEGLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYE-LCDNDDCGSKRKLSAIN 377
            ||.|::|.|||.||||.|:   ...|..|.|.||||.|:||..:.|| :.:....|.|..||...
  Rat   225 PLTIYMYQEGLVRFATEKF---DLSNLEDYYSHLTNSSINKLGASYEKIKEVVGQGCKWTLSRFF 286

  Fly   378 NWMRRHNYDVEEFW--SNVDDVIIKTVLSAWPVLKHNYHACFPGHDKIQACFEILGFDILVDWKL 440
            :::|  |:||::..  ..::.::|.|||           |..|.......|||:.|||||:|..|
  Rat   287 SYLR--NWDVDDLLLRRKINHMVILTVL-----------AMAPSVPVANNCFELFGFDILIDDNL 338

  Fly   441 KPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRK--RVKQRLLKIRGD 503
            ||::||||:||:.......|..|||.|:.|.:.|:..     ..:..|::|  |..|      |:
  Rat   339 KPWLLEVNYSPALSLECSTDVSVKRSLVHDIIELLYL-----NGLRSEEKKCGRTSQ------GN 392

  Fly   504 PPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQIAWEESHLGNFRKIMPPPDLS 568
            ..|.:.|    .|:.|:.|....|....:..........|.||.              |.|
  Rat   393 AMVSQAR----RSQQKLCAAPAPPSYASLIQFATCSKRSPAAQH--------------MCP---- 435

  Fly   569 KLDYYTRFYAQSHQVSIFAETAASKKREDLARKMRIQLEEKKAKQQQMLNGKAKRDARKRHTVLL 633
                              ..|..|:.||.|.|:.:: |..:.||.:..|  ||....||..::..
  Rat   436 ------------------KHTRTSQLREMLCRQNKL-LTREAAKSKPRL--KAWHSPRKMLSLCA 479

  Fly   634 PRAVREKNR 642
            .:::..|.:
  Rat   480 SQSLPRKTK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	103/300 (34%)
Ttll2	XP_006227981.1	TTL	98..371	CDD:281171	102/288 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920