DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and TTLL6

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001124390.1	Gene:	TTLL6 / 284076	HGNCID:	26664	Length:	891	Species:	Homo sapiens

Alignment Length:	590	Identity:	237/590 - (40%)
Similarity:	346/590 - (58%)	Gaps:	73/590 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WFSPEQSPPLQPMSPRRRMKKTRCLKRRTAADKQVDDNSPYYGPSSGENSPMPAEEAKLQGFIQL 115
            |:.|..|      |..|.|.:...|      :.|..:||...|.||.|:   |.|...| .|::.
Human    37 WYFPRAS------SQAREMPQCPTL------ESQEGENSEEKGDSSKED---PKETVAL-AFVRE 85

  Fly   116 NNKTYRVECPTRVLNPPMNVDEERPASETKSTICV--SNSRYAMIGKISKTLGYKLVKESKMWNI 178
            |         ....|...|..::......|..:.:  |:.||..:.:.::..|::...|...|.:
Human    86 N---------PGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTL 141

  Fly   179 LWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQDYKIFPKTWMLPADYG 243
            .|:|....:|....||.:|:|||||||.||||||||:||::||||:||:|::.||:||.||||:|
Human   142 YWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWG 206

  Fly   244 DAMNYALNHK-RTFILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYT 307
            |...|:.:.| :|:|.|||||.||:||::|..:|.|.|.|.:|||.||.:|.:|||:|||||:|.
Human   207 DLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYV 271

  Fly   308 LITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDNDDCGSKRK 372
            |:||.|||||||||||||||||..|..|...|.:|:.|||||||:||.:|::.  .:...|||||
Human   272 LVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFS--RDAHSGSKRK 334

  Fly   373 LSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLKHNYHACFPGHDKIQACFEILGFDILVD 437
            ||..:.::..|:|:||:.|.:::||||||::||.|:::||||.|||.|....|||||||||||:|
Human   335 LSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLD 399

  Fly   438 WKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVK--QRLLKI 500
            .||||::|||||||||.|:.::|:|||..|:.|||.|::....||:::|:|:|:|.:  |:..
Human   400 HKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCC-- 462

  Fly   501 RGDPPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQIAWEESHLGNFRKIMPPP 565
                          :.:.:|:..||....|             |.:...:|:.:.|.||.|.|..
Human   463 --------------SREMRIEEAKGFRAVQ-------------LKKTETYEKENCGGFRLIYPSL 500

  Fly   566 DLSKLDYYTRFYAQSHQVSIFAETAASKKREDLAR----KMRIQLEEK---KAKQQQMLNGKAKR 623
            :..|   |.:|:..::  |:|..|.||:.||:.||    ::|::.|:|   ..|:.:|....|..
Human   501 NSEK---YEKFFQDNN--SLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGE 560

  Fly   624 DARKR 628
            ..||:
Human   561 QVRKK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	168/290 (58%)
TTLL6	NP_001124390.1	TTL	154..441	CDD:281171	168/288 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I946
eggNOG	1	0.900	-	-		E1_KOG2158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1604
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251554at2759
OrthoFinder	1	1.000	-	-		FOG0005255
OrthoInspector	1	1.000	-	-		mtm8667
orthoMCL	1	0.900	-	-		OOG6_102355
Panther	1	1.100	-	-	O	PTHR12241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830