DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL6B and ttll5

DIOPT Version :9

Sequence 1:	NP_651549.1	Gene:	TTLL6B / 43282	FlyBaseID:	FBgn0039501	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_017207366.2	Gene:	ttll5 / 100006339	ZFINID:	ZDB-GENE-100922-236	Length:	1190	Species:	Danio rerio

Alignment Length:	621	Identity:	183/621 - (29%)
Similarity:	288/621 - (46%)	Gaps:	137/621 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 LGYKLVK-ESKM-------------------WNILWSDSFPGVELFKNMKRFQQINHFPGMIEIC 209
            |.:|:|: ||::                   :|::|:.|.....|.::::.||::||||...|:.
Zfish    60 LAFKIVRTESRLVRGILVNHGFHEVHPNSNDFNLMWTGSHLKPYLLRSLQDFQKVNHFPRSYELT 124

  Fly   210 RKDLLSRNLNRMLKIFP-QDYKIFPKTWMLPADYGDAMNYALNHKRTFILKPDSGAQGRGIWLTN 273
            |||.|.:|:.||.:... .::.|.|:|::|||:|.:..|.....|..:|:||.:.::||||:|.:
Zfish   125 RKDRLYKNIQRMQQSHGFHNFSIVPQTFVLPAEYQEFSNSFSKDKGPWIIKPVASSRGRGIYLVS 189

  Fly   274 DLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPG 338
            ::..|...|.::...||..|||||.:|||:|:|.|:||.|||.|::|.||||||||.||...| .
Zfish   190 NISQIPLDENILVSRYISNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVKYDHAT-A 253

  Fly   339 NANDLYMHLTNYSVNKRNSHYELCDN---DDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIK 400
            |..:.:||||||||||::|.|..||:   :|.|:|..:||:..::|:...|.......::|:|||
Zfish   254 NIKNQFMHLTNYSVNKKSSDYVSCDDPEVEDYGNKWSMSAMLRYLRQEGKDTTLLMGQIEDLIIK 318

  Fly   401 TVLSAWPVLKHNY-----HACFPGHDKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVD 460
            .||||...:..:.     |.|        .|||:.|||:|:|..|||::||||.|||...:..:|
Zfish   319 AVLSAEIHIATSCKMFVPHRC--------NCFELYGFDVLIDSNLKPWLLEVNLSPSLACDAPLD 375

  Fly   461 REVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRL--GGGTSKPKIDAQ 523
            .:||..:|.|..:||..|..                      ||.:::||.  .|...:.||..|
Zfish   376 LKVKASMISDMFSLVGFVCQ----------------------DPLLRQPRAERAGFDLRLKIPTQ 418

  Fly   524 K-------GSPDAQPVDVEPEAEDHG---------------PLAQQIAWEESHLGNFRKIMPPPD 566
            |       .|..|.|   :.:.|.||               .:.:::..|....|.|.:|.|.||
Zfish   419 KHQRQRPASSSSADP---QTQREKHGCKHTDDTLSLSAEEMKVLRRVQEEYERRGGFIRIFPTPD 480

  Fly   567 L-----SKLDYYTRFYAQSHQVSIFAETAASK--KREDLARKMRIQLEEKKAKQQQMLNGKAKRD 624
            .     ..|:|.|...|.          .|:|  .|..|..:.|:|..:..:   .:|.......
Zfish   481 TWEIYSGYLEYKTSLNAM----------LANKLFHRRSLTSRSRVQATDGIS---LVLGAFYTHH 532

  Fly   625 ARKRHTVLLPRAVREKNRINFFRLRENWSPGFISDAEERLRHTWLHMRAEAIRTLKITENIYSNL 689
            ..:....||....|:|.|          .|..:|             |......:|.:.:.:::.
Zfish   533 VVQYERKLLTLEARKKRR----------KPARVS-------------RRRPPTGVKCSPSPHTSE 574

  Fly   690 YETGL-----LTNTDMVVYP--HLYHNLQHGYDIKR 718
            .|.|:     :.::|....|  :|.|.||.|:|:.:
Zfish   575 NEDGVEGQMEVQSSDQHTQPKVNLLHILQQGWDLSK 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6B	NP_651549.1	TTL	196..486	CDD:281171	122/298 (41%)
ttll5	XP_017207366.2	TTL	111..387	CDD:281171	119/284 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920