DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5984 and flnb

DIOPT Version :9

Sequence 1:	NP_651548.1	Gene:	CG5984 / 43281	FlyBaseID:	FBgn0039500	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_021330210.1	Gene:	flnb / 563023	ZFINID:	ZDB-GENE-041026-1	Length:	2239	Species:	Danio rerio

Alignment Length:	326	Identity:	97/326 - (29%)
Similarity:	137/326 - (42%)	Gaps:	71/326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QEMRLNTQAASSA---SACS--------SSGSGLEGNSPEEGGIFGRYQRTP--DADAYP----- 52
            :.:..|.:||.:|   |.||        ..|: :..:..|..|.||.....|  ..|.|.
Zfish  1921 ENITYNQKAAPTASIGSECSLAFKLPDVDPGT-MSAHVYEPSGSFGEAVILPRTGRDIYVVSFLA 1984

  Fly    53 -----------------SESPRVYVAPELTDAG--KVQLLHFPSGAVRVNSPLGF-IIKRNGVKG 97
                             |..|..|....|...|  |||:............|..| |..|....|
Zfish  1985 KEMGVYNVSIQNKGQTISGCPLQYTVGPLGRGGSEKVQVWGQSLQTALATVPADFNIWSREAGAG 2049

  Fly    98 NFEVRVEGPSGQPIQPVRQQQLDPERFQIDCQLDAGA---GLYKVHIKCNSVTLPRSPFIIVAIA 159
            ...|.||||.  .|:....:|:|.     .|.:...|   |.|:|.:..|...:.:|||::..||
Zfish  2050 ALSVSVEGPG--EIELHFDEQMDG-----SCIVTYTAQQPGDYEVSVMFNEDHVSQSPFLVSVIA 2107

  Fly   160 GATES---------------------IDGKPASSSVPISDSDASRVQSRGLGLTHVSLVERNEFT 203
             ||::                     |:....||:.|:..||||:|...|.||:...|..:|.|.
Zfish  2108 -ATDTAVSDQTQLCNGHGEASLSGPQINTTSDSSAEPVLLSDASKVICHGPGLSKGFLGRKNTFY 2171

  Fly   204 VDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWGEQHVPGSPFSL 268
            |||.:||.|:|.||:.|...|||.|.:.|:|:..:|:.|.|.:.|.|:|.||||::|:|||||.:
Zfish  2172 VDCSKAGRNLLFVGMHGPTVPCERVSIIHMGQCQYRINYAVKERGKYVLAVKWGDEHIPGSPFYI 2236

  Fly   269 S 269
            |
Zfish  2237 S 2237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5984	NP_651548.1	Filamin	65..154	CDD:279024	25/94 (27%)
		Filamin	179..266	CDD:279024	41/86 (48%)
		IG_FLMN	181..271	CDD:214720	42/89 (47%)
flnb	XP_021330210.1	SAC6	21..>248	CDD:227401
		IG_FLMN	265..356	CDD:214720
		IG_FLMN	360..443	CDD:214720
		IG_FLMN	456..545	CDD:214720
		IG_FLMN	606..689	CDD:214720
		IG_FLMN	699..780	CDD:214720
		IG_FLMN	812..900	CDD:214720
		Filamin	991..1063	CDD:332480
		IG_FLMN	1078..1169	CDD:214720
		Filamin	1193..1253	CDD:332480
		Filamin	1375..1448	CDD:332480
		Filamin	<1580..1631	CDD:332480
		IG_FLMN	1648..1734	CDD:214720
		IG_FLMN	1742..1820	CDD:214720
		IG_FLMN	1825..1915	CDD:214720
		IG_FLMN	2019..2108	CDD:214720	27/96 (28%)
		IG_FLMN	2149..2238	CDD:214720	42/89 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830