DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5984 and Flnb

DIOPT Version :9

Sequence 1:	NP_651548.1	Gene:	CG5984 / 43281	FlyBaseID:	FBgn0039500	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001074896.1	Gene:	Flnb / 286940	MGIID:	2446089	Length:	2602	Species:	Mus musculus

Alignment Length:	336	Identity:	92/336 - (27%)
Similarity:	139/336 - (41%)	Gaps:	118/336 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DAYPSESPRVYVAPELT---DAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQP 110
            |.:..:||  |:.|.:.   ||..:.:|......::||.|..|.|:.||.||..:.:|..||| .
Mouse  2268 DEHIPDSP--YLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSG-A 2329

  Fly   111 IQPVRQQQLDPERF------------QIDCQLDA---------------------------GAGL 136
            ::.....:|:|:::            .||.:.:.                           ||||
Mouse  2330 VEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGL 2394

  Fly   137 ------------------------------YKVHIKCNSVT------------------------ 147
                                          .||.:.|..:.
Mouse  2395 ETGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMAPGNYLIGVKYGGP 2459

  Fly   148 --LPRSPF---------IIVAIAGATESI--------DGKPASSSVPISDSDASRVQSRGLGLTH 193
              :.||||         :....|..|.||        ..:...|::|.|.||||:|.|:|.||:.
Mouse  2460 NHISRSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKSSSDASKVTSKGAGLSK 2524

  Fly   194 VSLVERNEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWGE 258
            ..:.:::.|.|||.:|||||||:||.|...|||||.::|:|:..:.|||.|.:.|||:|.|||||
Mouse  2525 AFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGKQQYNVTYVVKERGDYVLAVKWGE 2589

  Fly   259 QHVPGSPFSLS 269
            :|:|||||.::
Mouse  2590 EHIPGSPFHVT 2600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5984	NP_651548.1	Filamin	65..154	CDD:279024	31/195 (16%)
		Filamin	179..266	CDD:279024	47/86 (55%)
		IG_FLMN	181..271	CDD:214720	47/89 (53%)
Flnb	NP_001074896.1	Actin-binding	1..239
		CH	17..121	CDD:237981
		CH	141..237	CDD:237981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267
		Filamin 1	249..347
		Filamin	253..344	CDD:279024
		IG_FLMN	254..350	CDD:214720
		Filamin 2	349..446
		Filamin	352..442	CDD:279024
		IG_FLMN	354..449	CDD:214720
		Filamin 3	447..543
		Filamin	449..540	CDD:279024
		IG_FLMN	452..545	CDD:214720
		Filamin 4	544..636
		IG_FLMN	550..632	CDD:214720
		Filamin	551..632	CDD:279024
		Filamin 5	640..736
		Filamin	644..733	CDD:279024
		IG_FLMN	645..739	CDD:214720
		Filamin 6	737..839
		Filamin	740..836	CDD:279024
		IG_FLMN	742..842	CDD:214720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..862
		Filamin 7	840..938
		Filamin	844..935	CDD:279024
		IG_FLMN	845..941	CDD:214720
		Filamin 8	939..1034
		Filamin	941..1031	CDD:279024
		IG_FLMN	945..1037	CDD:214720
		Filamin 9	1035..1127
		Filamin	1037..1124	CDD:279024
		IG_FLMN	1040..1130	CDD:214720
		Filamin 10	1128..1222
		Filamin	1130..1217	CDD:279024
		IG_FLMN	1133..1225	CDD:214720
		Filamin 11	1223..1322
		Filamin	1225..1319	CDD:279024
		IG_FLMN	1229..1325	CDD:214720
		Filamin 12	1323..1415
		IG_FLMN	1328..1417	CDD:214720
		Filamin	1328..1412	CDD:279024
		Filamin 13	1416..1511
		Filamin	1418..1508	CDD:279024
		IG_FLMN	1421..1514	CDD:214720
		Filamin 14	1512..1608
		Filamin	1516..1605	CDD:279024
		IG_FLMN	1517..1611	CDD:214720
		Filamin 15	1609..1704
		Filamin	1612..1701	CDD:279024
		IG_FLMN	1614..1707	CDD:214720
		Hinge 1. /evidence=ECO:0000250	1705..1728
		PepSY_TM	<1718..>1791	CDD:304937
		Filamin 16	1729..1813
		Filamin	<1756..1811	CDD:279024
		IG_FLMN	<1757..1816	CDD:214720
		Filamin 17	1816..1908
		Filamin	1819..1905	CDD:279024
		IG_FLMN	1824..1910	CDD:214720
		Filamin 18	1919..1994
		Filamin 19	1997..2089
		Filamin	2000..2086	CDD:279024
		IG_FLMN	2002..2091	CDD:214720
		Filamin 20	2091..2185
		IG_FLMN	<2126..2187	CDD:214720
Filamin	<2132..2181	CDD:279024
Filamin 21	2188..2280		4/13 (31%)
IG_FLMN	2193..2283	CDD:214720	5/16 (31%)
Filamin	2193..2276	CDD:279024	3/9 (33%)
Filamin 22	2282..2375		20/93 (22%)
IG_FLMN	2301..2378	CDD:214720	17/77 (22%)
Filamin	2301..2372	CDD:279024	17/71 (24%)
Filamin 23	2379..2471		11/91 (12%)
Filamin	2381..2468	CDD:279024	10/86 (12%)
IG_FLMN	2384..2473	CDD:214720	11/88 (13%)
Self-association site, tail. /evidence=ECO:0000250	2472..2602		56/129 (43%)
Hinge 2. /evidence=ECO:0000250	2472..2506		5/33 (15%)
Filamin	2509..2598	CDD:279024	48/88 (55%)
IG_FLMN	2512..2601	CDD:214720	47/89 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830