DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5984 and FLNC

DIOPT Version :9

Sequence 1:NP_651548.1 Gene:CG5984 / 43281 FlyBaseID:FBgn0039500 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001449.3 Gene:FLNC / 2318 HGNCID:3756 Length:2725 Species:Homo sapiens


Alignment Length:336 Identity:88/336 - (26%)
Similarity:136/336 - (40%) Gaps:118/336 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 DAYPSESPRVYVAPELT-DAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQPIQ 112
            |.:..:||.|.....|: ||.::.:.......::||.|..|.::.||.:|..:.||..||| .::
Human  2389 DEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSG-AVE 2452

  Fly   113 PVRQQQLDPERFQIDCQLDAGAGLYKVHIKCNSVTLPRSPF------------------------ 153
            .....:||.::..|.. :....|::.:.:|.|...:|.|||                        
Human  2453 ECYVSELDSDKHTIRF-IPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLE 2516

  Fly   154 ------------------------------------------------------IIVAIA-GATE 163
                                                                  .::||. |..:
Human  2517 GGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQ 2581

  Fly   164 SIDGKP------------------------------------ASSSVPISDSDASRVQSRGLGLT 192
            .|.|.|                                    :.||:|...||||:|.:||.||:
Human  2582 HIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLS 2646

  Fly   193 HVSLVERNEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWG 257
            ...:.::|.|||||.:||:||::|||.|.:.|||||.|:|:|..::.|||.|.:.|||||:||||
Human  2647 QAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG 2711

  Fly   258 EQHVPGSPFSL 268
            ::.||||||.:
Human  2712 DESVPGSPFKV 2722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5984NP_651548.1 Filamin 65..154 CDD:279024 24/167 (14%)
Filamin 179..266 CDD:279024 48/86 (56%)
IG_FLMN 181..271 CDD:214720 48/88 (55%)
FLNCNP_001449.3 actin-binding domain 1..268
Actin-binding 1..259
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
CH 37..141 CDD:237981
CH 165..257 CDD:214479
Filamin 1 270..368
Filamin 274..365 CDD:279024
IG_FLMN 275..371 CDD:214720
Filamin 2 370..468
Filamin 373..464 CDD:279024
IG_FLMN 375..471 CDD:214720
Filamin 3 469..565
Filamin 471..562 CDD:279024
IG_FLMN 474..567 CDD:214720
Filamin 4 566..658
Filamin 569..655 CDD:279024
IG_FLMN 572..661 CDD:214720
Filamin 5 662..758
Filamin 665..755 CDD:279024
IG_FLMN 667..761 CDD:214720
Filamin 6 759..861
Filamin 762..858 CDD:279024
IG_FLMN 764..864 CDD:214720
Filamin 7 862..960
Filamin 866..957 CDD:279024
IG_FLMN 867..963 CDD:214720
Filamin 8 961..1056
Filamin 963..1052 CDD:279024
IG_FLMN 967..1060 CDD:214720
Filamin 9 1057..1149
Filamin 1059..1146 CDD:279024
IG_FLMN 1062..1151 CDD:214720
Filamin 10 1150..1244
Filamin 1152..1239 CDD:279024
IG_FLMN 1155..1247 CDD:214720
Filamin 11 1245..1344
Filamin 1247..1341 CDD:279024
IG_FLMN 1251..1347 CDD:214720
Filamin 12 1345..1437
Filamin 1348..1434 CDD:279024
IG_FLMN 1350..1439 CDD:214720
Filamin 13 1438..1533
Filamin 1440..1530 CDD:279024
IG_FLMN 1443..1536 CDD:214720
Filamin 14 1534..1630
Filamin 1538..1627 CDD:279024
IG_FLMN 1539..1633 CDD:214720
Filamin 1634..1731 CDD:279024
Filamin 15 1635..1734
IG_FLMN 1636..1732 CDD:214720
Hinge I 1734..1766
Hinge 1 1735..1758
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1740..1765
Filamin 16 1759..1853
IG_FLMN <1795..1855 CDD:214720
Filamin <1795..1849 CDD:279024
Filamin 17 1854..1946
Filamin 1856..1943 CDD:279024
IG_FLMN 1862..1948 CDD:214720
Filamin 18 1947..2033
Filamin 19 2036..2128
Filamin 2039..2125 CDD:279024
IG_FLMN 2041..2130 CDD:214720
Intradomain insert, mediate targeting to Z lines 2162..2243
Filamin <2238..2302 CDD:279024
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2240..2260
IG_FLMN <2244..2308 CDD:214720
Filamin 20, mediates interaction with XIRP1 2244..2306
Filamin 21 2309..2401 4/11 (36%)
IG_FLMN 2314..2402 CDD:214720 4/12 (33%)
Filamin 2314..2398 CDD:279024 3/8 (38%)
Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 2403..2724 84/322 (26%)
Filamin 2407..2493 CDD:279024 23/87 (26%)
Filamin 2502..2589 CDD:279024 6/86 (7%)
IG_FLMN 2505..2595 CDD:214720 6/89 (7%)
Self-association site, tail. /evidence=ECO:0000250 2593..2725 53/130 (41%)
Hinge II 2593..2630 2/36 (6%)
Hinge 2 2593..2629 2/35 (6%)
Filamin 2632..2721 CDD:279024 49/88 (56%)
IG_FLMN 2635..2724 CDD:214720 48/88 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0518
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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