DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5984 and FLNB

DIOPT Version :9

Sequence 1:NP_651548.1 Gene:CG5984 / 43281 FlyBaseID:FBgn0039500 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001157789.1 Gene:FLNB / 2317 HGNCID:3755 Length:2633 Species:Homo sapiens


Alignment Length:336 Identity:89/336 - (26%)
Similarity:137/336 - (40%) Gaps:118/336 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 DAYPSESPRVYVAPELT---DAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQP 110
            |.:..|||  |:.|.:.   ||.::.::......::||.|..|.|:.||.||..:.:|..||| .
Human  2299 DEHIPESP--YLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSG-A 2360

  Fly   111 IQPVRQQQLDPERF------------QIDCQLDA---------------------------GAGL 136
            ::.....:|:|:::            .||.:.:.                           |.||
Human  2361 VEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGL 2425

  Fly   137 ------------------------------YKVHIKCNS-------VTLPRSP--FIIVAIAGAT 162
                                          .||.:.|..       :..|.:|  ::|....|..
Human  2426 EGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGP 2490

  Fly   163 ESIDGKP----------------------------------ASSSVPISDSDASRVQSRGLGLTH 193
            ..|.|.|                                  ..|::|.:.||||:|.|:|.||:.
Human  2491 NHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSK 2555

  Fly   194 VSLVERNEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWGE 258
            ..:.:::.|.|||.:|||||||:||.|...|||||.::|:|...:.|||.|.:.|||:|.|||||
Human  2556 AFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGE 2620

  Fly   259 QHVPGSPFSLS 269
            :|:|||||.::
Human  2621 EHIPGSPFHVT 2631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5984NP_651548.1 Filamin 65..154 CDD:279024 27/169 (16%)
Filamin 179..266 CDD:279024 47/86 (55%)
IG_FLMN 181..271 CDD:214720 47/89 (53%)
FLNBNP_001157789.1 Filamin 2412..2499 CDD:279024 13/86 (15%)
IG_FLMN 2415..2504 CDD:214720 13/88 (15%)
Self-association site, tail. /evidence=ECO:0000250 2503..2633 51/129 (40%)
Hinge 2. /evidence=ECO:0000250 2503..2537 1/33 (3%)
Interaction with FLNA 2 2538..2633 49/94 (52%)
Filamin 2540..2629 CDD:279024 48/88 (55%)
IG_FLMN 2543..2632 CDD:214720 47/89 (53%)
Actin-binding 1..239
CH 17..121 CDD:237981
CH 141..237 CDD:237981
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..267
Filamin 1 249..347
Filamin 253..344 CDD:279024
IG_FLMN 254..350 CDD:214720
Filamin 2 349..446
Filamin 352..443 CDD:279024
IG_FLMN 354..449 CDD:214720
Filamin 3 447..543
Filamin 449..540 CDD:279024
IG_FLMN 452..545 CDD:214720
Filamin 4 544..636
IG_FLMN 550..632 CDD:214720
Filamin 551..632 CDD:279024
Filamin 5 640..736
Filamin 644..733 CDD:279024
IG_FLMN 645..739 CDD:214720
Filamin 6 737..839
Filamin 740..836 CDD:279024
IG_FLMN 742..842 CDD:214720
Filamin 7 840..938
Filamin 844..935 CDD:279024
IG_FLMN 845..941 CDD:214720
Filamin 8 939..1034
Filamin 941..1031 CDD:279024
IG_FLMN 945..1037 CDD:214720
Filamin 9 1035..1127
Filamin 1037..1124 CDD:279024
IG_FLMN 1040..1130 CDD:214720
Filamin 1130..1217 CDD:279024
IG_FLMN 1133..1225 CDD:214720
Filamin 1225..1319 CDD:279024
IG_FLMN 1229..1325 CDD:214720
IG_FLMN 1328..1417 CDD:214720
Filamin 1328..1412 CDD:279024
Filamin 1418..1539 CDD:279024
IG_FLMN 1421..1545 CDD:214720
Filamin 14 1543..1639
Filamin 1547..1636 CDD:279024
IG_FLMN 1548..1642 CDD:214720
Filamin 15 1640..1735
Filamin 1643..1732 CDD:279024
IG_FLMN 1645..1738 CDD:214720
Hinge 1. /evidence=ECO:0000250 1736..1759
PepSY_TM <1749..>1804 CDD:304937
Filamin 16 1760..1844
Filamin <1787..1842 CDD:279024
IG_FLMN <1788..1847 CDD:214720
Filamin 17 1847..1939
Filamin 1850..1936 CDD:279024
IG_FLMN 1855..1941 CDD:214720
Interaction with the cytoplasmic tail of GP1BA 1893..2179
Filamin 2031..2117 CDD:279024
IG_FLMN 2033..2122 CDD:214720
Interaction with FLNA 1 2091..2256
IG_FLMN <2157..2218 CDD:214720
Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 2161..2633 89/336 (26%)
Filamin <2163..2212 CDD:279024
IG_FLMN 2224..2314 CDD:214720 6/16 (38%)
Filamin 2224..2307 CDD:279024 4/9 (44%)
IG_FLMN 2318..2409 CDD:214720 18/91 (20%)
Filamin 2332..2403 CDD:279024 17/71 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160135
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0518
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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