DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5984 and FLNA

DIOPT Version :9

Sequence 1:	NP_651548.1	Gene:	CG5984 / 43281	FlyBaseID:	FBgn0039500	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001104026.1	Gene:	FLNA / 2316	HGNCID:	3754	Length:	2647	Species:	Homo sapiens

Alignment Length:	327	Identity:	84/327 - (25%)
Similarity:	135/327 - (41%)	Gaps:	116/327 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ESPRVY-VAPELTDAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQPIQPVRQQ 117
            :||.|. ||....||.::.:.......::||.|..|.:..||.||..:.:|..||| .::.....
Human  2318 DSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSG-ALEECYVT 2381

  Fly   118 QLDPERFQIDCQLDAGAGLYKVHIKCNSVTLPRSPF--------------IIVAI-AGATESIDG 167
            ::|.:::.:.. :....|:|.:.:|.|...:|.|||              ::.|. ||....:.|
Human  2382 EIDQDKYAVRF-IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTG 2445

  Fly   168 KPA-------------------------------------------------------------- 170
            .||
Human  2446 NPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGS 2510

  Fly   171 -------------------SSSVPISD-----------------SDASRVQSRGLGLTHVSLVER 199
                               :|||.:..                 :|||:|.::||||:...:.::
Human  2511 PFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQK 2575

  Fly   200 NEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWGEQHVPGS 264
            :.|||||.:||:|||||||.|.|.||||::|:|:|..::.|:|.:.|.|:|.||||||::|:|||
Human  2576 SSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGS 2640

  Fly   265 PF 266
            |:
Human  2641 PY 2642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5984	NP_651548.1	Filamin	65..154	CDD:279024	23/102 (23%)
		Filamin	179..266	CDD:279024	46/86 (53%)
		IG_FLMN	181..271	CDD:214720	46/86 (53%)
FLNA	NP_001104026.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Actin-binding	2..274
		CH	44..148	CDD:237981
		CH	172..264	CDD:214479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..294
		Filamin 1	276..374
		Filamin	280..371	CDD:279024
		IG_FLMN	281..375	CDD:214720
		Filamin 2	376..474
		Filamin	379..471	CDD:279024
		IG_FLMN	381..477	CDD:214720
		Filamin 3	475..570
		Filamin	477..567	CDD:279024
		IG_FLMN	480..571	CDD:214720
		Filamin 4	571..663
		IG_FLMN	577..659	CDD:214720
		Filamin	578..659	CDD:279024
		Filamin 5	667..763
		Filamin	670..760	CDD:279024
		IG_FLMN	672..766	CDD:214720
		Filamin 6	764..866
		Filamin	767..863	CDD:279024
		IG_FLMN	769..869	CDD:214720
		Filamin 7	867..965
		Filamin	871..961	CDD:279024
		IG_FLMN	872..968	CDD:214720
		Filamin 8	966..1061
		Filamin	968..1057	CDD:279024
		IG_FLMN	972..1064	CDD:214720
		Filamin 9	1062..1154
		Filamin	1064..1151	CDD:279024
		IG_FLMN	1067..1156	CDD:214720
		Filamin 10	1155..1249
		Filamin	1158..1244	CDD:279024
		IG_FLMN	1160..1252	CDD:214720
		Filamin 11	1250..1349
		Filamin	1252..1345	CDD:279024
		IG_FLMN	1256..1352	CDD:214720
		Filamin 12	1350..1442
		Filamin	1353..1439	CDD:279024
		IG_FLMN	1355..1442	CDD:214720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1382
		Filamin 13	1443..1539
		Filamin	1445..1536	CDD:279024
		IG_FLMN	1448..1542	CDD:214720
		Interaction with furin. /evidence=ECO:0000250	1490..1607
		Filamin 14	1540..1636
		Filamin	1544..1633	CDD:279024
		IG_FLMN	1545..1639	CDD:214720
		Filamin	1640..1736	CDD:279024
		Filamin 15	1649..1740
		IG_FLMN	1665..1743	CDD:214720
		Hinge 1	1741..1778
		Filamin 16	1779..1860
		IG_FLMN	<1797..1861	CDD:214720
		Filamin	<1797..1855	CDD:279024
		Filamin 17	1861..1950
		Filamin	1866..1949	CDD:279024
		IG_FLMN	1868..1954	CDD:214720
		Filamin 18	1951..2039
		Filamin 19	2042..2131
		Filamin	2045..2130	CDD:279024
		IG_FLMN	2047..2136	CDD:214720
		Filamin 20	2132..2230
Filamin 21	2233..2325		3/6 (50%)
IG_FLMN	2238..2328	CDD:214720	5/9 (56%)
Filamin	2238..2322	CDD:279024	2/3 (67%)
Filamin 22	2327..2420		23/94 (24%)
Filamin	2329..2417	CDD:279024	22/89 (25%)
IG_FLMN	2332..2423	CDD:214720	22/92 (24%)
Filamin 23	2424..2516		6/91 (7%)
Filamin	2427..2513	CDD:279024	6/85 (7%)
IG_FLMN	2429..2519	CDD:214720	6/89 (7%)
Self-association site, tail	2517..2647		50/126 (40%)
Hinge 2	2517..2551		3/33 (9%)
Filamin	2554..2643	CDD:279024	47/89 (53%)
IG_FLMN	2557..2646	CDD:214720	46/86 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810