DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5984 and FLNA

DIOPT Version :10

Sequence 1:NP_651548.1 Gene:CG5984 / 43281 FlyBaseID:FBgn0039500 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001104026.1 Gene:FLNA / 2316 HGNCID:3754 Length:2647 Species:Homo sapiens


Alignment Length:327 Identity:84/327 - (25%)
Similarity:135/327 - (41%) Gaps:116/327 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 ESPRVY-VAPELTDAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQPIQPVRQQ 117
            :||.|. ||....||.::.:.......::||.|..|.:..||.||..:.:|..||| .::.....
Human  2318 DSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSG-ALEECYVT 2381

  Fly   118 QLDPERFQIDCQLDAGAGLYKVHIKCNSVTLPRSPF--------------IIVAI-AGATESIDG 167
            ::|.:::.:.. :....|:|.:.:|.|...:|.|||              ::.|. ||....:.|
Human  2382 EIDQDKYAVRF-IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTG 2445

  Fly   168 KPA-------------------------------------------------------------- 170
            .||                                                              
Human  2446 NPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGS 2510

  Fly   171 -------------------SSSVPISD-----------------SDASRVQSRGLGLTHVSLVER 199
                               :|||.:..                 :|||:|.::||||:...:.::
Human  2511 PFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQK 2575

  Fly   200 NEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWGEQHVPGS 264
            :.|||||.:||:|||||||.|.|.||||::|:|:|..::.|:|.:.|.|:|.||||||::|:|||
Human  2576 SSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGS 2640

  Fly   265 PF 266
            |:
Human  2641 PY 2642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5984NP_651548.1 Filamin 65..154 CDD:395505 23/102 (23%)
IG_FLMN 181..271 CDD:214720 46/86 (53%)
FLNANP_001104026.1 Actin-binding 2..274
CH_FLNA_rpt1 25..153 CDD:409157
CH_FLNA_rpt2 156..269 CDD:409161
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..294
Filamin 1 276..374
IG_FLMN 281..375 CDD:214720
Filamin 2 376..474
IG_FLMN 381..477 CDD:214720
Filamin 3 475..570
IG_FLMN 480..571 CDD:214720
Filamin 4 571..663
IG_FLMN 577..659 CDD:214720
Filamin 5 667..763
IG_FLMN 672..766 CDD:214720
Filamin 6 764..866
IG_FLMN 769..869 CDD:214720
Filamin 7 867..965
IG_FLMN 872..968 CDD:214720
Filamin 8 966..1061
IG_FLMN 972..1064 CDD:214720
Filamin 9 1062..1154
IG_FLMN 1067..1156 CDD:214720
Filamin 10 1155..1249
IG_FLMN 1160..1252 CDD:214720
Filamin 11 1250..1349
IG_FLMN 1256..1352 CDD:214720
Filamin 12 1350..1442
IG_FLMN 1355..1442 CDD:214720
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1361..1382
Filamin 13 1443..1539
IG_FLMN 1448..1542 CDD:214720
Interaction with furin. /evidence=ECO:0000250 1490..1607
Filamin 14 1540..1636
IG_FLMN 1545..1639 CDD:214720
Filamin 15 1649..1740
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
IG_FLMN 1665..1743 CDD:214720
Hinge 1 1741..1778
Filamin 16 1779..1860
IG_FLMN <1797..1861 CDD:214720
Filamin 17 1861..1950
IG_FLMN 1868..1954 CDD:214720
Filamin 18 1951..2039
Filamin 19 2042..2131
IG_FLMN 2047..2136 CDD:214720
Filamin 20 2132..2230
Filamin 21 2233..2325 3/6 (50%)
IG_FLMN 2238..2328 CDD:214720 5/9 (56%)
Filamin 22 2327..2420 23/94 (24%)
IG_FLMN 2332..2423 CDD:214720 22/92 (24%)
Filamin 23 2424..2516 6/91 (7%)
IG_FLMN 2429..2519 CDD:214720 6/89 (7%)
Self-association site, tail 2517..2647 50/126 (40%)
Hinge 2 2517..2551 3/33 (9%)
IG_FLMN 2557..2646 CDD:214720 46/86 (53%)
Blue background indicates that the domain is not in the aligned region.

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