DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5984 and flnc

DIOPT Version :9

Sequence 1:	NP_651548.1	Gene:	CG5984 / 43281	FlyBaseID:	FBgn0039500	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	XP_031754944.1	Gene:	flnc / 100329116	XenbaseID:	XB-GENE-493579	Length:	2767	Species:	Xenopus tropicalis

Alignment Length:	337	Identity:	91/337 - (27%)
Similarity:	139/337 - (41%)	Gaps:	118/337 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DAYPSESPRVY-VAPELTDAGKVQLLHFPSGAVRVNSPLGFIIKRNGVKGNFEVRVEGPSGQPIQ 112
            |.:..:||.|. ||....||.::.:.......:.||.|..|.::.||.:|..:.:|..|||. ::
Frog  2431 DEHIPDSPFVVPVASRSDDARRLTVTSLQETGIIVNQPASFAVQLNGARGVIDAKVHTPSGM-VE 2494

  Fly   113 PVRQQQLDPERFQIDCQLDAGAGLYKVHIKCNSVTLPRSPF------------------------ 153
            .....::|.:::.|.. :....|::.:.:|.|...:|.|||
Frog  2495 ECYVSEVDSDKYSIRF-IPRENGVHSIDVKFNGRHIPGSPFKIRVGEQSQAGDPGLVTAYGLGLE 2558

  Fly   154 ------------------------------------------------------IIVAIA-GATE 163
                                                                  .:::|. |..:
Frog  2559 GGVTGRPSEFIVSTLNAGAGSLSVTIDGPSKVKLDCQDSPEGYKVSYTPMAPGNYLISIKYGGPQ 2623

  Fly   164 SIDGKP-----------------------------ASSSV-------PISDSDASRVQSRGLGLT 192
            .|.|.|                             :|:||       |...||||:|.|||.||:
Frog  2624 HIVGSPFKARVTGVRLSGGHSLHETSTVLVETVTKSSASVGGYAMTAPKFSSDASKVVSRGPGLS 2688

  Fly   193 HVSLVERNEFTVDCGQAGSNMLLVGVLGQRGPCEEVVVRHLGRGIHRVTYRVCDPGDYILVVKWG 257
            ...:.::|.|||||.:||:|||:|||.|.:.|||||.|:|:|..::.|||.|.|.|||||:||||
Frog  2689 KAFVGQKNTFTVDCSKAGTNMLMVGVHGPKTPCEEVYVKHMGNRLYNVTYTVKDKGDYILIVKWG 2753

  Fly   258 EQHVPGSPFSLS 269
            :|:||||||.::
Frog  2754 DQNVPGSPFQVA 2765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5984	NP_651548.1	Filamin	65..154	CDD:279024	22/166 (13%)
		Filamin	179..266	CDD:279024	52/86 (60%)
		IG_FLMN	181..271	CDD:214720	52/89 (58%)
flnc	XP_031754944.1	CH_FLNC_rpt1	22..146	CDD:409159
		CH_FLNC_rpt2	150..264	CDD:409163
		IG_FLMN	275..371	CDD:214720
		IG_FLMN	375..471	CDD:214720
		IG_FLMN	518..611	CDD:214720
		IG_FLMN	616..705	CDD:214720
		IG_FLMN	711..805	CDD:214720
		IG_FLMN	808..908	CDD:214720
		IG_FLMN	911..1007	CDD:214720
		IG_FLMN	1011..1103	CDD:214720
		IG_FLMN	1107..1195	CDD:214720
		IG_FLMN	1199..1291	CDD:214720
		IG_FLMN	1295..1391	CDD:214720
		IG_FLMN	1394..1483	CDD:214720
		IG_FLMN	1487..1580	CDD:214720
		IG_FLMN	1583..1677	CDD:214720
		IG_FLMN	1680..1776	CDD:214720
		IG_FLMN	<1834..1898	CDD:214720
		IG_FLMN	1905..1991	CDD:214720
		IG_FLMN	2084..2173	CDD:214720
		IG_FLMN	2264..2350	CDD:214720
		IG_FLMN	2356..2444	CDD:214720	4/12 (33%)
		IG_FLMN	2450..2540	CDD:214720	21/91 (23%)
		IG_FLMN	2547..2636	CDD:214720	5/88 (6%)
		IG_FLMN	2677..2766	CDD:214720	52/89 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910