Protein Alignment DNApol-alpha73 and pola2

DIOPT Version :9

• Sequence 1: NP_733206.3
• Gene: DNApol-alpha73 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_955875.2
• Gene: pola2 / 322059
• ZFINID: ZDB-GENE-030131-778
• Length: 600
• Species: Danio rerio
• Alignment Length: 649
• Identity: 193/649 - (29%)
• Similarity: 313/649 - (48%)
• Gaps: 97/649 - (14%)

  Fly     3 EELKQQFDEMGV----EPADAVLGRCAELAITYNIHDATEFVEQWMAFSLSHLQGEDPAIENLGD 63
            |::|.:.|...:    :..|.:|.:|....:|     ..|.|.:|.|||.:..| ....:|||..
Zfish     7 EDIKSELDTFNIAFNNDTIDKMLEQCFCHRLT-----GEEIVFEWFAFSSTRKQ-LPLTLENLDQ 65

  Fly    64 FERKVLQLRKDKAGYKATGQKAKSYGSPSVQDTSSLATYGVMEDDPMLDDYVSESAVDSS--ALH 126
            ||::||..:|.........|..|:....|:|:......    |::.|||.| |..|..|.  ||.
Zfish    66 FEQEVLNKKKKPKSTSKGSQINKTRDINSIQELIRAEE----EEENMLDSY-STPAKGSQKRALT 125

  Fly   127 TPKAKKQSDRTANLKGAAL-FSPASYTPQSAKRKAGLETPSN--SVAGKPGDIVDTFGHPKLLAG 188
            ||:..:.....|.|...:| .||||::|.:        |||.  .:.|..|::|.|||   .:.|
Zfish   126 TPEHPQSKRGVARLASPSLMLSPASFSPSA--------TPSQKYGMRGGRGEVVSTFG---AVQG 179

  Fly   189 SSWQSQMEHTVPVTQKLLHNDAPLTIANLGYM-------NDLLTDRC----HNLRVRFNQTGPAL 242
            ..|..:.:..|.|  ::|.......|::..||       .|:||.:.    ..||..||....|.
Zfish   180 PRWMGKGQTAVSV--EMLDGGENSLISSYKYMFQRLRDVRDVLTGKIEELGEELRTNFNIEEFAP 242

  Fly   243 VDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVLDDDVEDEMDPTL 307
            |...:            ||        .:..:|.:..:.:|.|:|.|    ||.:..:::....:
Zfish   243 VSLPV------------QD--------SITVLGQVCCDSNGKLNAQS----VLLEAGQEQGGRQV 283

  Fly   308 TLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQIDRELQFV-------VA 365
            .::.|.:|..|:||||||:.:|..|.|:..:..:::....|....|.::.:|:..|       :|
Zfish   284 PVDLSELKEFSLFPGQVVVMEGMNPSGEKLVATKLYEGIPLPFYCPSEVKQEMDEVCEPVMVMIA 348

  Fly   366 SGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMV--GELAETFDTFFEKMIGGIM 428
            .||:|.|..|.|:||.||:..:...||||.:|.|||:|:.|:.:  .::.|||:|.|::.:..|:
Zfish   349 CGPYTPSESLTYDPLLDLITIINKDRPDVCILFGPFVDSKHEQIEKNQVTETFETIFKRCMDSIV 413

  Fly   429 ESI-GSHTAVLVVTSQKDAMALSVYPTPPPAL---RRTYPNLYMLPDPSLVDLDGFTLGVTSTDV 489
            |.. |:...::.|.||:|.....:||.||..|   :.....:.:.|||..:.:...|.|:||||:
Zfish   414 EGTKGTACKLVFVPSQRDVHHHYIYPQPPFNLTISKEDTARVTLAPDPCTLLIGNVTFGLTSTDI 478

  Fly   490 VDHLLSHEFAVNAG-ERMHRAINHLFHQGSFYPLYPPADE-DMAYDSQLALKYAQLKQL---PNV 549
            :.|:.:.|.:...| ||..|.:.|:..|.|:|||||||:| :|.||     |:.|..|:   |::
Zfish   479 LFHMGAEEISSGTGTERFSRIMKHMLTQRSYYPLYPPAEEVNMDYD-----KFQQFSQMSLTPDI 538

  Fly   550 LILPSDQRHFIRLVNDCLVINPGRVADKK-GGTFARFLVAPS---VPGKAANMFNSVACQVQRI 609
            |:.||:.|:||:.|..|:.:||||:...: |||:.|.|:.|:   |.||..:  ..:|.||.:|
Zfish   539 LVAPSELRYFIKDVIGCVCVNPGRLTKGQIGGTYGRLLIQPNPALVEGKRVS--PCIAGQVVKI 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	49/166 (30%)
		DNA_pol_E_B	363..561	CDD:281968	77/215 (36%)
pola2	NP_955875.2	Pol_alpha_B_N	23..246	CDD:285602	69/246 (28%)
		DNA_pol_E_B	346..550	CDD:281968	76/208 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574878
Domainoid	1	1.000	138	1.000	Domainoid score	I4818
eggNOG	1	0.900	-	-		E1_COG5214
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48121
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3472
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D239034at33208
OrthoFinder	1	1.000	-	-		FOG0004882
OrthoInspector	1	1.000	-	-		oto39084
orthoMCL	1	0.900	-	-		OOG6_102459
Panther	1	1.100	-	-	LDO	PTHR23061
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R342
SonicParanoid	1	1.000	-	-		X3994
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790