DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha73 and spb70

DIOPT Version :9

Sequence 1:	NP_733206.3	Gene:	DNApol-alpha73 / 43278	FlyBaseID:	FBgn0005696	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_587765.1	Gene:	spb70 / 2539135	PomBaseID:	SPCC553.09c	Length:	574	Species:	Schizosaccharomyces pombe

Alignment Length:	561	Identity:	137/561 - (24%)
Similarity:	232/561 - (41%)	Gaps:	136/561 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PMLDDYVSESAVDSSALHTPKAKKQSDR--TANLKGAALFSPASYTPQSAKRKAGLETPS---NS 168
            |.||       :|:........|.|.:|  .|.||            |:.:||:..:.|.   :|
pombe    43 PKLD-------LDTFKAFAKDMKFQMERQVKATLK------------QNPERKSIKQIPGMNIDS 88

  Fly   169 VAGKPGDIVDTFGHPKLLAGSSWQSQMEHTVPVTQ--KLLHNDAPLTIANLGYMNDLLTD----- 226
            :.|.|           :...:|..|.|:.:.|.|:  :|..:||...:..|.....::|.
pombe    89 ILGLP-----------VKTTASGDSLMQESKPSTETFELNSSDAGRVLEVLNKELKIVTSKPSAP 142

  Fly   227 -----------RCHNLRVRFNQ--TGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLH-----A 273
                       :..|.|:.:.:  ....::|.::....|..|..|....:.|.:...|.     .
pombe   143 SKLVIVANFDLKAFNYRIMYQKLYDSSEVLDDRIELFSALTCRKYNISDEDLANPSELTQEPVVV 207

  Fly   274 VGMIHSED---DGPLDAHSAFMAVLDDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGK 335
            ||.|..|.   .|.|:.:|   .:|:..........:.|....:.|.||||||:|..||..|.|.
pombe   208 VGRIVVESTNLGGRLNQNS---ILLESSRRLGAGVRVRLKVDDLPSYSIFPGQIVSVKGSNPSGN 269

  Fly   336 TFMVEEIHTERKLTPATPLQI----------------DRELQFVVASGPFTDSTDLFYEPLHDLL 384
            .|:.:||      .|..||..                ::.:...:||||::...||.:.||..::
pombe   270 MFIAKEI------LPIPPLPFPSSSKQEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMI 328

  Fly   385 KYLKDHRPDVLVLTGPFLDADHKMV------GELAETFDTFFEKMIGGIMESIGSHTAVLVVTSQ 443
            .|:..:..|:::|.|||||.:|.::      |..|.:.:..|::.:..|:..:  ....:::...
pombe   329 SYVNKNPVDLVILCGPFLDINHILIRTGNITGTSATSLEELFKERVTPILSQL--TCPCILIPHI 391

  Fly   444 KDAMALSVYPT-PPPALRRTY----PNLYMLPDPSLVDLDGFTLGVTSTDVVDH--------LLS 495
            .|  |.|.:|. |..|..|..    .|....|:|.:..::....||::.|::.|        |.|
pombe   392 ND--AASDHPAWPQDAFNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLPS 454

  Fly   496 HEFAVNAGERMHRAINHLFHQGSFYPLYP--------PADEDMAYDSQLALKYAQ-LKQLPNVLI 551
            |      |....|.::|:.||..||||:|        |::.|:|:     ||..: |..:|::||
pombe   455 H------GNLFARLVSHVLHQRHFYPLFPGGSLEKCNPSNLDIAH-----LKLGEFLNTMPDILI 508

  Fly   552 LPSDQRHFIRLVNDCLVINPGRVADKKG---GTFARFLVAP 589
            ||||.|:|::.|.:.:.:|||:..  ||   ||||:..:||
pombe   509 LPSDLRYFVKNVENVVSLNPGKAT--KGINLGTFAKLTIAP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	17/75 (23%)
DNApol-alpha73	NP_733206.3	DNA_pol_E_B	363..561	CDD:281968	63/225 (28%)
spb70	NP_587765.1	POL12	1..574	CDD:227539	137/561 (24%)
		Pol_alpha_B_N	7..198	CDD:285602	34/184 (18%)
		DNA_pol_E_B	307..518	CDD:281968	63/225 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2054
eggNOG	1	0.900	-	-		E1_COG5214
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004882
OrthoInspector	1	1.000	-	-		oto100706
orthoMCL	1	0.900	-	-		OOG6_102459
Panther	1	1.100	-	-	LDO	PTHR23061
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R342
SonicParanoid	1	1.000	-	-		X3994
TreeFam	1	0.960	-	-
	11	10.800