Protein Alignment DNApol-alpha73 and POLA2

DIOPT Version :9

• Sequence 1: NP_733206.3
• Gene: DNApol-alpha73 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_002680.2
• Gene: POLA2 / 23649
• HGNCID: 30073
• Length: 598
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 188/630 - (29%)
• Similarity: 301/630 - (47%)
• Gaps: 60/630 - (9%)

  Fly     3 EELKQQFDEMGVEPADAVLGRCAELAITYNIHDATEFVEQWMAFSLS-HLQGEDPAIENLGDFER 66
            ::|.::....|::..:|::.:..||.:.|. .:....|.:.:||..| |..|....|  |..||.
Human     6 QQLAEELQIFGLDCEEALIEKLVELCVQYG-QNEEGMVGELIAFCTSTHKVGLTSEI--LNSFEH 67

  Fly    67 KVLQLRKDKAGYKATGQKAKSYGSPSVQDTSSLATYGVMEDDP--MLDDYVSES-AVDSSALHTP 128
            :.|..|..||.:..    .|..|....:|..|:.....:|::.  :|:.|.:.| .....|:.||
Human    68 EFLSKRLSKARHST----CKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTP 128

  Fly   129 KAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPS---NSVAGKPGDIVDTFGHPKLLAGSS 190
            :........:......|.||:|::|.:        |||   ||.:.: |::|.:||   |..|.|
Human   129 ETPLTKRSVSTRSPHQLLSPSSFSPSA--------TPSQKYNSRSNR-GEVVTSFG---LAQGVS 181

  Fly   191 WQSQMEHTVPVTQKLLHNDAPLTIANLGYMNDLLTDRCHNLRVRFNQTGPALVDKKLGQAGAAEC 255
            | |.......::.|:|.....|| .:...|...|.|....|..:..:.|..|  |:..:..|...
Human   182 W-SGRGGAGNISLKVLGCPEALT-GSYKSMFQKLPDIREVLTCKIEELGSEL--KEHYKIEAFTP 242

  Fly   256 IWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVLDDDVEDEMDPTLTLNFSRVKSASIF 320
            :..|....|.       .:|.|..:.:|.|:..|   .:|:.|.|......:.::.|.:|..|:|
Human   243 LLAPAQEPVT-------LLGQIGCDSNGKLNNKS---VILEGDREHSSGAQIPVDLSELKEYSLF 297

  Fly   321 PGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQIDRELQ---FVVASGPFTDSTDLFYEPLHD 382
            |||||:.:|....|:..:..:::....|....|.:.|.:.:   .:||.||:|.|..:.|:||.|
Human   298 PGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLD 362

  Fly   383 LLKYLKDHRPDVLVLTGPFLDADHKMVGE--LAETFDTFFEKMIGGIME---SIGSHTAVLVVTS 442
            |:..:...||||.:|.||||||.|:.|..  |...|:..|::.:..|:|   |.|||  ::.|.|
Human   363 LIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSH--LVFVPS 425

  Fly   443 QKDAMALSVYPTPP----PALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLLSHEFAVNAG 503
            .:|.....|||.||    ...|.....:..:.:|..:.::|...|:||||::.||.:.|.:.::|
Human   426 LRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSG 490

  Fly   504 --ERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQRHFIRLVNDC 566
              :|..|.:.|:..|.|:|||||| .||||.|.:....||||...|:|||:||:.|:|::.|..|
Human   491 TSDRFSRILKHILTQRSYYPLYPP-QEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGC 554

  Fly   567 LVINPGRVA-DKKGGTFAR-FLVAPSVPGKAANMFNSVACQVQRI 609
            :.:||||:. .:.|||||| :|..|:..| |......:|.||.||
Human   555 VCVNPGRLTKGQVGGTFARLYLRRPAADG-AERQSPCIAVQVVRI 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	41/168 (24%)
		DNA_pol_E_B	363..561	CDD:281968	81/208 (39%)
POLA2	NP_002680.2	Pol_alpha_B_N	<111..238	CDD:400634	35/142 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..167		15/62 (24%)
		POL12	<206..583	CDD:227539	127/391 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141967
Domainoid	1	1.000	135	1.000	Domainoid score	I4997
eggNOG	1	0.900	-	-		E1_COG5214
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48121
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3687
Isobase	1	0.950	-	0	Normalized mean entropy	S3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D239034at33208
OrthoFinder	1	1.000	-	-		FOG0004882
OrthoInspector	1	1.000	-	-		oto88860
orthoMCL	1	0.900	-	-		OOG6_102459
Panther	1	1.100	-	-	LDO	PTHR23061
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R342
SonicParanoid	1	1.000	-	-		X3994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740