Protein Alignment DNApol-alpha73 and div-1

DIOPT Version :9

• Sequence 1: NP_733206.3
• Gene: DNApol-alpha73 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_499268.1
• Gene: div-1 / 176439
• WormBaseID: WBGene00001002
• Length: 581
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 131/596 - (21%)
• Similarity: 238/596 - (39%)
• Gaps: 151/596 - (25%)

  Fly   108 DPMLDDYVS------ESAVDSSAL---------------HTPKAKKQSDR--------------- 136
            :.::||.||      :.:|||..|               |||::.|:..|
 Worm    43 EDIVDDVVSVMSNLGQKSVDSGILAKLEENLEAQAQKTVHTPRSVKKPARGRVPLAEKSGFILSG 107

  Fly   137 ----------------TANLKGAAL-FSPASYTPQSAK--RKAGLETPSNSVAGKPGDIVDTFGH 182
                            .|.|:|..| |||...:|.:.|  ::|           .|..:|.|...
 Worm   108 DPDDIEKPSHHLTNSAIAKLEGHFLDFSPFPGSPANEKFLKRA-----------DPSHVVTTIRG 161

  Fly   183 PKL----LAGSSWQSQMEHTVPVTQKLLHNDAPLTIANLGYMND-----------LLTDRCHNLR 232
            .|.    |.||   ::.:.|:.:..|     .|.|:    |..|           .:.|..|.::
 Worm   162 KKYQDKGLKGS---TKSDDTIRIISK-----TPSTL----YGGDKSSMVIEAKAQRMADIAHRIQ 214

  Fly   233 VRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVG-MIHSE--DDGPLDAHSAFMAV 294
            ..|.:    :||            |   ....:.|...::..| :||.|  |:.....||..:.:
 Worm   215 KSFEE----IVD------------W---GNPSIPSVDVVYTYGQVIHDETKDNEKFGEHSVALMI 260

  Fly   295 LDDDVEDEMDPTLTLNFSRV-KSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQIDR 358
            .|:|     ...:.::||:: :..::||||::..:|....|:...|::|.....| |..|::.|.
 Worm   261 NDED-----GTMIRMDFSKMTEDITLFPGQIIAVRGTNETGEELQVDKIFQPAAL-PVNPVETDT 319

  Fly   359 ELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVGE--LAETFDTFFE 421
            ..:...|.||:|.:.:..||.|.:||..:...:||:|:|.|||:|..:..:.:  ...|:|...|
 Worm   320 TKEIWFACGPYTATDNCGYEHLCELLDKVVAEKPDILMLAGPFVDKKNTFLNKPTFNITYDNLLE 384

  Fly   422 KMIGGIMES-IGSHTAVLV-VTSQKDAMALSVYPTPP----PALRRTYPNLYMLPDPSLVDLDGF 480
            .::..:.|: :|:.|.|:: ..:.:|.....|:|:.|    ..|.:....|..:.||.:..:.|.
 Worm   385 DLLLKVKETLVGTKTQVIIQPNASRDLCVPPVFPSAPFQQNRKLDKIKKELIFVADPCIFRISGV 449

  Fly   481 TLGVTSTDVVDHLLSHEFAVNAG----ERMHRAINHLFHQGSFYPLYP---PAD-EDMAYDSQLA 537
            .:.:||::.:..|.:.||..:|.    :|:.|..:||..|...|||.|   ||. .|:
 Worm   450 EVAMTSSEPIQALSNTEFHRSANQENIDRVARLSSHLLTQQCMYPLEPTEVPASMGDL------- 507

  Fly   538 LKYAQLKQLPNVLILPSDQRHFIRLVNDCLVINPGRVADKKGGTFARFLV----APSVPGKAANM 598
            |....:...|:::..|:......:.||..:.||...:|....|.:|:..:    ...:||:....
 Worm   508 LDVCCIGSTPHIVFAPTKLAPSAKCVNGSVFINSSTLAKGPTGNYAKMSINLNAGELMPGETVAD 572

  Fly   599 FNSVACQVQRI 609
            :..:  |:.:|
 Worm   573 YAQI--QILKI 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	25/126 (20%)
		DNA_pol_E_B	363..561	CDD:281968	54/213 (25%)
div-1	NP_499268.1	DNA_pol_E_B	324..531	CDD:281968	54/213 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156691
Domainoid	1	1.000	70	1.000	Domainoid score	I6264
eggNOG	1	0.900	-	-		E1_COG5214
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I3532
Isobase	1	0.950	-	0	Normalized mean entropy	S3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D239034at33208
OrthoFinder	1	1.000	-	-		FOG0004882
OrthoInspector	1	1.000	-	-		oto18466
orthoMCL	1	0.900	-	-		OOG6_102459
Panther	1	1.100	-	-	LDO	PTHR23061
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R342
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.740