Protein Alignment CG31064 and ZFYVE16

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_055548.4
• Gene: ZFYVE16 / 9765
• HGNCID: 20756
• Length: 1539
• Species: Homo sapiens
• Alignment Length: 888
• Identity: 175/888 - (19%)
• Similarity: 315/888 - (35%)
• Gaps: 251/888 - (28%)

  Fly   132 QQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVSVDGEWLC 196
            :|.|..|.      .||..|.:..||        |.:.|.|||...:.::      :..|.|  |
Human    20 EQNPDEQD------YLQDVQNAYDSN--------HCSVSSELASSQRTSL------LPKDQE--C 62

  Fly   197 LKELQDIDVAGGTGNQAAQTSEKLAGGSSSQ-----TG-GFGSNYNVGSSSS------KRNSKRF 249
            :......:.:.|| |:::...:.|.|.:|.|     || ...|:.:.|:|..      .|.||..
Human    63 VNSCASSETSYGT-NESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPI 126

  Fly   250 SGLSTGSGS-------------------GGNAGGGGGLDI-----------TDNARDT------- 277
            ..|.:..|:                   ..||....|||:           ||:..||
Human   127 CDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTDHDSDTVREQQND 191

  Fly   278 --AEIERSNLVNICKLVVK--ELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGP 338
              :|::...:..|.:|.:|  ..|..|..|.   .:::|..:..|..:|.::...:  ...|...
Human   192 ISSELQNREIGGIKELGIKVDTTLSDSYNYS---GTENLKDKKIFNQLESIVDFNM--SSALTRQ 251

  Fly   339 RKELW---DLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHR 400
            ..:::   |.||.....|       ..::|:..|:..:..|.......|.::..:..|...:...
Human   252 SSKMFHAKDKLQHKSQPC-------GLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKN 309

  Fly   401 EDSLF--------DYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLR 457
            ||...        ::..|......|:.|:..........:|    :|:.|:     :.|.|..|.
Human   310 EDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLD----LKDNDV-----IQDSSSALH 365

  Fly   458 SSSRNADAAPEDSAPPA-------LLDATGQGNMIAVLDQKNYI-------EELNRHLNATVGNL 508
            .||:  |.....|..||       |:::..:|:.:...:.|:.|       ||:..  :..:|..
Human   366 VSSK--DVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQN--SVVLGGE 426

  Fly   509 QAKVESLTTTNALMKED--LAIARNSLL------ALQAENQAMR-QSTSAGDNNST------GSG 558
            ..|      .|.|:|::  .:|...||:      .:..:...:| :|...||.:||      |..
Human   427 PFK------ENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLS 485

  Fly   559 G------------------SSDKDKEKASEELVEERRKNSELEKELKLQVSLKAE--SDMAMKLL 603
            |                  |:|.|.:......::|..|:..|..:.:|...|..:  ....:|..
Human   486 GTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSF 550

  Fly   604 EKDIHEKQDTIVSLRRQLD----DIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTID 664
            |:::::.:    |...|:|    |...|| .:|...:......:|...::.::    .|..:||:
Human   551 EENVNDSK----SQMNQIDMKGLDDGNIN-NIYFNAEAGAIGESHGINIICEI----VDKQNTIE 606

  Fly   665 QLEKKWSHDKSNLGEI--------LKTTSQTLTTQVTASEERA-----ARAEAESRIEREWRISL 716
                    :..:|||.        |.|:...:|.|::.|:..:     ||.:....:....|.|
Human   607 --------NGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSS- 662

  Fly   717 QEKELKLKEKIANLQGCLKELSEEKERNGKLKADL-DKVRTQWSEAQTTLEELGIQLSVSKLKVS 780
                              |:|:         |.|: |.:.::.|.|.|.:.......|.:..:||
Human   663 ------------------KDLN---------KPDVPDTIESEPSTADTVVPITCAIDSTADPQVS 700

  Fly   781 ------EMQDQERRQRQLLSGSAQSLQAMPEAVGSPGI--------WAPDSIATHCTACEREFNL 831
                  :::.........::.:..|   :||.....|:        |.|||.|.:|..|:.:|..
Human   701 FNSNYIDIESNSEGGSSFVTANEDS---VPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTF 762

  Fly   832 TRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
            |:|:||||:||::||..|......|...:    |..|||..||
Human   763 TKRRHHCRACGKVFCGVCCNRKCKLQYLE----KEARVCVVCY 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	25/167 (15%)
		Smc	<562..>807	CDD:440809	46/270 (17%)
		FYVE_RUFY1_like	813..874	CDD:277261	24/60 (40%)
ZFYVE16	NP_055548.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..491		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..678		9/65 (14%)
		FYVE_endofin	738..804	CDD:277268	26/68 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..850
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	884..907
		DUF3480	1167..1515	CDD:463419