Protein Alignment CG31064 and RUBCN

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: XP_006713890.1
• Gene: RUBCN / 9711
• HGNCID: 28991
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 999
• Identity: 182/999 - (18%)
• Similarity: 307/999 - (30%)
• Gaps: 374/999 - (37%)

  Fly    13 LSSANNNN------LSSTSGSGRIKSSSLATGSSASGSSSKPLRSAVKTPTSGSATSLSSGTMAA 71
            |.:...||      :.::..:.:.:|..|.|.|    .|...|.|:..||.:..|.....|:.::
Human   172 LEAVEQNNPRLLAQIDASMFARKHESPLLVTKS----QSLTALPSSTYTPPNSYAQHSYFGSFSS 232

  Fly    72 --KKAPQTGQQQVGKSAKSATAATPTGTTATAIGATATTRAQAAAAKSQKGQNPP-SQQVQPKQQ 133
              :..|..|.::  :|.....:..|.        ....:|...:.|:.|..|.|| |.....:..
Human   233 LHQSVPNNGSER--RSTSFPLSGPPR--------KPQESRGHVSPAEDQTIQAPPVSVSALARDS 287

  Fly   134 PPQPQQTQQQPLVLQQQQASNSSNTIALP-KASHANTSEELAGGVQDTIYLCNFRVSVDGEWLCL 197
            |..|.:.              ||:|:..| :||..::..:..|.           .|...|:|.:
Human   288 PLTPNEM--------------SSSTLTSPIEASWVSSQNDSPGD-----------ASEGPEYLAI 327

  Fly   198 KELQDIDVAGGT------GNQAAQTSEKLAGGSSSQT-------------GG------------F 231
            ..|   |..|.|      .:.|..:|..|...||||.             ||            |
Human   328 GNL---DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSF 389

  Fly   232 GSNYNVGSSSSKRNSKRFSGLSTGSGSGGNAGGGGGL------DITDNARDTAEIE-------RS 283
            .....:..:|..:.|...|...|...|.|..||...:      .|.::..|.|::.       :|
Human   390 SEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQS 454

  Fly   284 NLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGL--RPKKGLLGPRKELWDLL 346
            :.|:     ....|......||.|.|                |.|:  ||.:|
Human   455 SEVS-----TPSSLYMEYEGGRYLCS----------------GEGMFRRPSEG------------ 486

  Fly   347 QSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPH 411
            ||:..|..| ||. .|..||.....|.              .:|:.|.|.||
Human   487 QSLISYLSE-QDF-GSCADLEKENAHF--------------SISESLIAAIE------------- 522

  Fly   412 ALMMSDEIVVIMGILVGLNVIDCNL---CVKEEDL---DSQQGVIDFS----------------- 453
                               ::.||:   |::||::   ||.:.:.:..
Human   523 -------------------LMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLP 568

  Fly   454 LY-------LRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELN-RHLNATVGNLQA 510
            :|       .|.:|.::..:..|||.   |..:|..:.:...:.::..|..| .|::.
Human   569 MYQEAEHGSFRVTSSSSQFSSRDSAQ---LSDSGSADEVDEFEIQDGSEGSNLTHISK------- 623

  Fly   511 KVESLTTTNALMKEDLAIARN------SLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKAS 569
              ..|:.:.|.|..|..|.||      |.::.|:.:.....||||                |..:
Human   624 --NGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSA----------------EAVA 670

  Fly   570 EELVEERR-----KNSELEKELKLQVSLKAESDMAMKLL--------------EKDIHEKQDTI- 614
            ..|:::..     ..||||       .|..|.|...|||              ..||::.:..:
Human   671 MGLLKQFEGMQLPAASELE-------WLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVR 728

  Fly   615 -----------------------------------VSLRRQLDDIKQINLEMYRKLQDCK----- 639
                                               ..:|...|.||::....|.....|:
Human   729 GNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHEN 793

  Fly   640 ASLTHKTELMTKLEVQKEDMAS-TIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAE 703
            |.:...:.::.|.:..|..::: :.|.|.|.|:....|:.:|
Human   794 AQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI----------------------- 835

  Fly   704 AESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEEL 768
             .|.:.|  ::.|..:...|:.::.:::...|.....||    |....|.|....:      |:|
Human   836 -NSALYR--KVKLLNQVRLLRVQLCHMKNMFKTCRLAKE----LLDSFDTVPGHLT------EDL 887

  Fly   769 GIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQ--AMPEAVGSPGIWAPDSIATHCTACERE--- 828
            .: .|::.|..:...:...|..:|....|..::  .:.:|.|           ..|..|:.|
Human   888 HL-YSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKG-----------FICEFCQNEDDI 940

  Fly   829 ---FNLTRRKHHCRSCGEIFCKAC 849
               |.|    |.||:|.|  ||||
Human   941 IFPFEL----HKCRTCEE--CKAC 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	28/163 (17%)
		Smc	<562..>807	CDD:440809	46/307 (15%)
		FYVE_RUFY1_like	813..874	CDD:277261	14/43 (33%)
RUBCN	XP_006713890.1	RUN_RUBCN	34..190	CDD:439048	3/17 (18%)
		Herpes_BLLF1	<197..462	CDD:282904	61/311 (20%)
		zf-RING_9	777..977	CDD:464030	44/236 (19%)