DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31064 and RUFY1

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_079434.3	Gene:	RUFY1 / 80230	HGNCID:	19760	Length:	708	Species:	Homo sapiens

Alignment Length:	721	Identity:	283/721 - (39%)
Similarity:	410/721 - (56%)	Gaps:	106/721 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 ELQDIDVAGGTGNQAAQTSEKLAGGSSS--------QTGGFGSNYNVGSSSSKRNSKRFSGLSTG 255
            |:.|.....|.|:..:.|..:.|.|.|:        .||      |:.:|..       |.|...
Human    37 EIVDRSQLPGPGDLRSATRPRAAEGWSAPILTLARRATG------NLSASCG-------SALRAA 88

  Fly   256 SGSGGNAGGGGGLDITDNARDTAEI--ERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFF 318
            :|.||...|.|    |..|....::  ||:||:::.||.:|.||:.:|..||.||:||.|||.||
Human    89 AGLGGGDSGDG----TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFF 149

  Fly   319 IVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIA 383
            :|:||.|.|||:.||..:|..|..:..|:.||..||||.||..|||:||.::|.:||.||||.:|
Human   150 VVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLA 214

  Fly   384 LMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQG 448
            ||||||:|||:.||:::. .|.::|||.||||.:|.:||:|:||||||:|.|||:|.||||||.|
Human   215 LMQKKLADYLKVLIDNKH-LLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVG 278

  Fly   449 VIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVE 513
            ||||||||: ..::.|...|..            .:..|||||||:|||||||:.|||:||.|::
Human   279 VIDFSLYLK-DVQDLDGGKEHE------------RITDVLDQKNYVEELNRHLSCTVGDLQTKID 330

  Fly   514 SLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASE-------- 570
            .|..||:.::|:|:.|.:.:.:||.|.|.:|:........|..|...:.:|.:...|
Human   331 GLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQG 395

  Fly   571 ----------ELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIK 625
                      :|.||::...||||||:||:.:|.|.::||||||||.||||||:|:||:||:::|
Human   396 LDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVK 460

  Fly   626 QINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKWSHDK----------SNLGEI 680
            .|||:|:.|.|:.::||..|.|.:|..|.:...:.|::.|:|::..|.:          ..|.:.
Human   461 AINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQE 525

  Fly   681 LKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQ-----EKELK--LKEKIANLQGCLKELS 738
            |......|..|::...|:.:..|.|.:.|:|.|.:||     ||:..  |:.::..::|..|||.
Human   526 LGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELR 590

  Fly   739 EEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAM 803
            |.::.    ||:|.|:   ..|.:..|:|:|:.||.||||:.::::    ..|.|.|.|
Human   591 ELQDE----KAELQKI---CEEQEQALQEMGLHLSQSKLKMEDIKE----VNQALKGHA------ 638

  Fly   804 PEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVR 868
                     |..|..||||..||:||:::|||||||:||.|||..||.:.|.|   ...| ||||
Human   639 ---------WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELAL---PSYP-KPVR 690

  Fly   869 VCDNCY 874
            |||:|:
Human   691 VCDSCH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	68/122 (56%)
		CASP_C	495..>634	CDD:285395	65/156 (42%)
		FYVE_RUFY1_like	813..874	CDD:277261	34/60 (57%)
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		5/19 (26%)
		RUN	147..270	CDD:280855	68/123 (55%)
		DUF4201	451..612	CDD:290581	47/167 (28%)
		AAA_23	<486..601	CDD:290211	28/118 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..522		4/28 (14%)
		Interaction with RAB4. /evidence=ECO:0000250	615..625		6/9 (67%)
		FYVE_RUFY1	634..704	CDD:277297	38/82 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149897
Domainoid	1	1.000	213	1.000	Domainoid score	I2751
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1505
Isobase	1	0.950	-	0	Normalized mean entropy	S4437
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329099at33208
OrthoFinder	1	1.000	-	-		FOG0004337
OrthoInspector	1	1.000	-	-		otm40735
orthoMCL	1	0.900	-	-		OOG6_103035
Panther	1	1.100	-	-	LDO	PTHR45956
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710