DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31064 and rufy3

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_012820361.1	Gene:	rufy3 / 779660	XenbaseID:	XB-GENE-1020955	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	710	Identity:	261/710 - (36%)
Similarity:	389/710 - (54%)	Gaps:	104/710 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 AQTSEKLAGGS---SSQTGGFGSNYNVGSSSSKRNSKRFSGL---STGSGSGG------------ 260
            |:..::.||.:   |....|....:..|:|||..:|..:...   |...||||
Frog    68 ARKQKQNAGSAPPKSLGAAGHPLQHYSGTSSSLSSSSPWQPSFPDSPSPGSGGLSPSSSLQLMMM 132

  Fly   261 --NAGGGGGLDITDNARDTAE--------IERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQ 315
              |..|.||    |::.:.|:        .||.||:|:.||.:|.|:|.:|..||.||||:.|||
Frog   133 MMNYTGVGG----DHSNEKAQKNPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ 193

  Fly   316 HFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWL 380
            .||:|:||.|.|||:.||..||..|..|..|:.||...|||.:|||||:|||.:||.:||.||||
Frog   194 QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLRTPVGRGRAWL 258

  Fly   381 RIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDS 445
            |:||||||||:|::||| :|:|.|.::|||:||||.:|..:|.|:||||||||.|.|:|.|||||
Frog   259 RLALMQKKLSEYMKALI-NRKDLLSEFYEPNALMMEEEGAIISGLLVGLNVIDANFCMKGEDLDS 322

  Fly   446 QQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQA 510
            |.||||||:||:..             |....:.|.|.:.|:||||||:|||||.|:|||.||||
Frog   323 QVGVIDFSMYLKEG-------------PIAKCSEGDGQITAILDQKNYVEELNRQLSATVNNLQA 374

  Fly   511 KVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTS--------AGDNNSTGSGGSSDKDKEK 567
            ||::|..:|..:.|:||:|.|.::.:|.|.:.:::.||        ......|..|.:..:.|
Frog   375 KVDALEKSNTKLTEELAVANNRIITMQEEMERIKEETSYYSEASKKVNKQERTADGQALSEVK-- 437

  Fly   568 ASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMY 632
              :.|.||.:...::||||::|:.::.|.::|||:|:||:.||||.:.:||:||||::.:..|:.
Frog   438 --KHLKEETQLRLDIEKELEVQIGMRQEMELAMKMLDKDVCEKQDALAALRQQLDDLRALKHELS 500

  Fly   633 RKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKW---SHDKSNLGEILKTTSQ-------T 687
            .|||....:|..|:||.::||.:...||:|:.|||::.   ..|:.:..|..|...|       :
Frog   501 FKLQSSDLALKQKSELNSRLEEKTNQMAATVKQLEQRLRVSERDRQSAEEANKLFKQEFGDKIES 565

  Fly   688 LTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLD 752
            |..:|....:..::.|||.:.:|...||...|. ..:.|.:.:.|.|     ::.|...:..|:.
Frog   566 LQLEVDRLRKHCSQYEAELKKDRNKHISSNHKG-SPETKTSPMGGLL-----QRNRKKMVNEDIH 624

  Fly   753 KVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDS 817
                |:.|...|...   |.:|::...|:|.:.       ||.|:..:....::|...|
Frog   625 ----QYREVDGTERP---QSAVNEKNESQMSNS-------LSSSSSVVSESEDSVLETG------ 669

  Fly   818 IATH---CTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
               |   |..|:.||:....|:.|::||.|||.:||.:.|||.::.    .|.|||:.|:
Frog   670 ---HSQVCQLCQSEFSNLLSKNVCKNCGGIFCPSCSANELPLPSSI----NPERVCNPCH 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	73/122 (60%)
		CASP_C	495..>634	CDD:285395	55/146 (38%)
		FYVE_RUFY1_like	813..874	CDD:277261	21/63 (33%)
rufy3	XP_012820361.1	RUN	194..315	CDD:367169	72/121 (60%)
		Smc	359..>584	CDD:224117	78/228 (34%)
		FYVE_RUFY3	674..722	CDD:277283	20/51 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2982
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1691
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329099at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5167
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.100