DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and zfyve28

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001071191.1	Gene:	zfyve28 / 777615	ZFINID:	ZDB-GENE-061103-208	Length:	969	Species:	Danio rerio

Alignment Length:	832	Identity:	158/832 - (18%)
Similarity:	242/832 - (29%)	Gaps:	349/832 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NPPSQQVQPKQQPPQPQQTQQQPLVLQQQQASNSSNTIALPKAS----------------HANTS 170
            :||||...|..: |:|....      ..:.:|.:|:|.|.|:.:                .:..|
Zfish   394 SPPSQNQSPAHR-PRPYNGS------SLEGSSATSSTQASPRRAPGSYHDDDRVFFMDDLESGLS 451

  Fly   171 EELAGG--VQDTIYLCNFRVSVDGEWL------------CLKEL---------QDIDVAGGTGNQ 212
            .||..|  ...|:.|.:...|....||            |.::|         .|..|.|..|.|
Zfish   452 SELCRGQLPLPTVCLRSPEGSSCNGWLTVCQSSDATNLGCQRKLSQSTESVGNSDRMVNGWEGLQ 516

  Fly   213 ---AAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSGLSTGSGSGGNAGGGGGLDIT--- 271
               :.||:|::|    ::|||...:..|..:....:....:.:...|......|.||.|..|
Zfish   517 DEDSVQTAEEIA----NRTGGMKLSATVIFNPHSPSLSDLAVVLPQSADAPEGGEGGALVATQCL 577

  Fly   272 ------------DNARDTAE---------IERSNLVNICKLVVKELLEQSLRYGRM-LDSDHLPL 314
                        ||..|..|         .|:..|.     :...:::.::..|.. ..:.||||
Zfish   578 LNSCVCCAGGCVDNHEDAMEPAGRSMALGFEKHKLT-----ITSSVIQSAVAAGSPGKGNGHLPL 637

  Fly   315 QHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAW 379
            .             |.|.:|.|             .|..|     ..||::
Zfish   638 T-------------LPPSQGHL-------------THSVP-----NCSVQN-------------- 657

  Fly   380 LRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLD 444
                              :.|||.                    |...|::...|..|
Zfish   658 ------------------QAREDE--------------------GSQDGIHYPCCEKC------- 677

  Fly   445 SQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQ 509
             ..||      |.:..|.:.   .:..|...|..||
Zfish   678 -SPGV------LLAQDRGSG---HEGGPSCTLQDTG----------------------------- 703

  Fly   510 AKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKD---------K 565
                ..|..||.:|     .|:.....|:::. .|:..|:...:...|..|||.|         .
Zfish   704 ----CQTQHNASVK-----GRSECFGKQSKDD-NRKINSSSQESPLSSVPSSDIDGVSVTTCSLS 758

  Fly   566 EKASEELVEERRKNSELEKEL---KLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQI 627
            ...:...|.....:|::.::|   ::||:|:|....|...:....|...|.|
Zfish   759 SSYAPSPVSSLTTSSDMSEDLDHQEIQVALQAAKLAAHNKIRSRFHSSSDLI------------- 810

  Fly   628 NLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQV 692
                 .:|..|                    ::...|||:..::   |:|..||||..:.:.|:.
Zfish   811 -----HRLFVC--------------------ISGVADQLQTNYA---SDLRSILKTLFEVMATKT 847

  Fly   693 TASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQ 757
            .                                     ||     ..||.:.|...
Zfish   848 D-------------------------------------QG-----DNEKPKKGPCL--------- 861

  Fly   758 WSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHC 822
               ....||:..:                  .::.:|.|..:.:|.......|..|.||.....|
Zfish   862 ---GSAVLEDCAL------------------CQETISSSELAAKAREGQFEDPPEWVPDEACNSC 905

  Fly   823 TACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
            .||:..|.:.||||||||||:|||..||.|:.| |...||. ||||||.:||
Zfish   906 IACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAP-LPRYGQM-KPVRVCTHCY 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	15/122 (12%)
		CASP_C	495..>634	CDD:285395	24/150 (16%)
		FYVE_RUFY1_like	813..874	CDD:277261	33/60 (55%)
zfyve28	NP_001071191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..360
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..437		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..777		11/62 (18%)
		FYVE_LST2	892..956	CDD:277270	36/66 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870