Protein Alignment CG31064 and ZFYVE28

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_066023.2
• Gene: ZFYVE28 / 57732
• HGNCID: 29334
• Length: 887
• Species: Homo sapiens
• Alignment Length: 893
• Identity: 177/893 - (19%)
• Similarity: 294/893 - (32%)
• Gaps: 342/893 - (38%)

  Fly   268 LDITDNARDTAEIE---------RSNLVNICKLVVKELLEQS-------LRYGRMLDSDHLPLQH 316
            ||..|..:|.....         :.|::||...::.|.:.|.       :::...:..|:|..|.
Human    37 LDSLDGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQL 101

  Fly   317 FF---------IVIEHVL-GHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRD--LPTV 369
            :|         |::...| ...:||.      .||   |.:|:|       |:..::||  |..:
Human   102 WFGAECLAAGSIIMNRELESMAMRPL------AKE---LTRSLE-------DVRGALRDQALRDL 150

  Fly   370 RTHIGRARAWLR---IALMQKKLSDYLQALI---EHRE-------------------------DS 403
            .|:..:.|..||   :...:.:|| |:.|::   ..||                         ..
Human   151 NTYTEKMREALRHFDVLFAEFELS-YVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQD 214

  Fly   404 LFDYYEPHALMMS-DEIVVIMGILV---------------------------------------G 428
            :.|.||| |||.| ..:.::.|::|                                       .
Human   215 MIDDYEP-ALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEE 278

  Fly   429 LNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRN-ADAAPEDSAP-----PALLDATGQGNMIAV 487
            |:.::.|||:.::        ::|.  :|:..:. |..||..|||     |....|......:|.
Human   279 LHTLERNLCISQD--------VEFP--IRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELAC 333

  Fly   488 L----DQKNYIEELNRHLN--------------------------------ATVGNLQAKVESLT 516
            .    ||:  :|:|:|.::                                |:.|..:.:..|..
Human   334 SMQYDDQE--LEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDE 396

  Fly   517 TTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEK------------AS 569
            .......:|:.....:|         .|..:.||.....||..:..::|.:            ||
Human   397 EERVFFMDDVEGTAEAL---------ARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPAS 452

  Fly   570 EELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYR- 633
            |:  ||...|:.||.|.....||...|  :...|:..:|     :.......||.:...:..:|
Human   453 EK--EEDLSNNNLEAEGTDGASLAGTS--SCSCLDSRLH-----LDGWEVGADDAETAEMIAHRT 508

  Fly   634 ---KLQDCKASLTHKTELMTKLE--VQKEDMAS-------------------------------- 661
               ||   .|::....:..|.|:  |..::.||
Human   509 GGMKL---SATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSC 570

  Fly   662 ------TIDQLEKKW-------------------------------SHDKSNLGEILKTTS---- 685
                  .:::|.:|.                               |.|.||..|....||
Human   571 GDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCL 635

  Fly   686 -QTLTTQV-TASEER-----AARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEK-- 741
             .|..:|| |||..:     |.:.|.|:|.......|..|....|....::..|   ..|.:|
Human   636 PHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSSSSTAG---SCSSDKMG 697

  Fly   742 ------ERNGKLKADLDKVRTQWSEAQTTLEELGIQLS--VSKLKVS------------------ 780
                  ..:...:|..:|:|:::..:...:..|.:.:|  ..:|:.:
Human   698 PEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMAT 762

  Fly   781 --EMQDQERRQR---QLLSGSAQSLQAMPEAVGS--------------PGIWAPDSIATHCTACE 826
              |..|:|:.::   .|.|.:.:......|.:.|              |..|.||.....||||:
Human   763 KPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACK 827

  Fly   827 REFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
            ..|.:.||||||||||:|||..||.|:.| |...||. ||||||.:||
Human   828 APFTVIRRKHHCRSCGKIFCSRCSSHSAP-LPRYGQV-KPVRVCTHCY 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	43/253 (17%)
		Smc	<562..>807	CDD:440809	63/375 (17%)
		FYVE_RUFY1_like	813..874	CDD:277261	34/60 (57%)
ZFYVE28	NP_066023.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	308..327		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..396		3/41 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..474		17/72 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	599..714		24/117 (21%)
		FYVE_LST2	810..874	CDD:277270	37/66 (56%)