DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and rufy2

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001231848.1	Gene:	rufy2 / 569096	ZFINID:	ZDB-GENE-070424-66	Length:	698	Species:	Danio rerio

Alignment Length:	752	Identity:	296/752 - (39%)
Similarity:	414/752 - (55%)	Gaps:	148/752 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 QDIDVAGGTGNQAAQ--------TSEKLAG---GSSSQTGGFGSNYNVGSSSSKRNSKRFSGLST 254
            ||:.:|...||:...        ..:|.||   .|.:...|.|.......:.:::.|:.||
Zfish     7 QDLVLAEAEGNKERTQVFGILRLQEDKSAGEKASSPAMKSGDGRWQAPIFALARKASETFS---- 67

  Fly   255 GSGSGGNAGGGGGLDITDNA-----------------RDTAEIERSNLVNICKLVVKELLEQSLR 302
                       ||:.:....                 ||...:||:||:|:.||.:|.|:|.:|.
Zfish    68 -----------GGIHVLPKVTEPKTSPFTEEWGARAFRDPMAMERANLLNMAKLSIKGLIESALS 121

  Fly   303 YGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLP 367
            :||.||||:.|||.||:|:||.|.|||:.||..||..|.||..|:.||..||||.:|.|||||||
Zfish   122 FGRTLDSDYPPLQQFFVVMEHCLKHGLKVKKSFLGYNKSLWGPLEMVEKLCPEAGEIAASVRDLP 186

  Fly   368 TVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVI 432
            .::|.:||||||||:|||||||:|||:.||. |:|.|.::||..|:|:.:|..||:|:|||||||
Zfish   187 GLKTPLGRARAWLRLALMQKKLADYLRLLIT-RKDILSEFYESSAVMLEEEGAVIVGLLVGLNVI 250

  Fly   433 DCNLCVKEEDLDSQQGVIDFSLYL-------RSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQ 490
            |.|||||.||||:|.||||||:||       ||..||                   |.:.|:|||
Zfish   251 DANLCVKGEDLDTQVGVIDFSMYLKNDIDDYRSEERN-------------------GQIAAILDQ 296

  Fly   491 KNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSA------ 549
            |||:|||||.||:||..||.:||||...|:.:.|:||||:|:::.||.||..:|...|.
Zfish   297 KNYVEELNRQLNSTVQGLQGRVESLEKNNSKLIEELAIAKNNIIKLQEENHQLRTENSVILMKAQ 361

  Fly   550 -------GD-----NNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKL 602
                   ||     :....|....|:...:|..:|.||.:...::|.||.:|||:|.|.:|||||
Zfish   362 QRLAVTEGDLSCELDTYKQSRQGLDEMYNEARRQLKEECQLRQDVENELVVQVSMKQEMEMAMKL 426

  Fly   603 LEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLE 667
            |||||||||||::.||.|||::|.||:|||:|:|....|:..|.:::.:||.:...:.:|:.|||
Zfish   427 LEKDIHEKQDTLIGLRHQLDEVKAINVEMYQKMQSSDDSMRQKNDMIARLEEKTNQITATMKQLE 491

  Fly   668 -----------------KKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRIEREWRIS 715
                             :|:..|.:|..|       :|..|:...|::..:.|.:.:|||:||.:
Zfish   492 QRLQDAERERASAEDGVRKFKQDFTNKAE-------SLQKQIVQREKQMTQLETDLKIERDWRQT 549

  Fly   716 LQEKELKLKEKIANL-------QGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLS 773
            ||.:..:.:|.|..|       .|..||....::.|.:||...:       |.:..|||||.:||
Zfish   550 LQNELERERETITQLAAEAQQINGLKKEFHRLQDENTQLKGICE-------EQEHALEELGCKLS 607

  Fly   774 VSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHC 838
            .||||:.::::..:                  |:....:|..|..||||..||:||:::||||||
Zfish   608 ESKLKIEDIKEANK------------------ALQGGQVWLKDKDATHCKLCEKEFSISRRKHHC 654

  Fly   839 RSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCYA 875
            |:||||||.|||::.|||   ...| |||||||.|:|
Zfish   655 RNCGEIFCNACSDNELPL---PASP-KPVRVCDTCHA 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	74/122 (61%)
		CASP_C	495..>634	CDD:285395	71/156 (46%)
		FYVE_RUFY1_like	813..874	CDD:277261	37/60 (62%)
rufy2	NP_001231848.1	RUN	135..258	CDD:280855	75/123 (61%)
		Taxilin	300..625	CDD:286771	118/356 (33%)
		FYVE_RUFY2	626..696	CDD:277298	39/66 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584048
Domainoid	1	1.000	221	1.000	Domainoid score	I2543
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23064
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1401
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329099at33208
OrthoFinder	1	1.000	-	-		FOG0004337
OrthoInspector	1	1.000	-	-		otm24555
orthoMCL	1	0.900	-	-		OOG6_103035
Panther	1	1.100	-	-	O	PTHR45956
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760