DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and plekhm2

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001124255.1	Gene:	plekhm2 / 564823	ZFINID:	ZDB-GENE-081022-169	Length:	994	Species:	Danio rerio

Alignment Length:	713	Identity:	150/713 - (21%)
Similarity:	242/713 - (33%)	Gaps:	213/713 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLP--------LQHFFIVIEHVLGHGLRP- 331
            |..:::...|.|| .|.||:|  ||  |....: |..|        ||.....::|.|.:||:.
Zfish     2 DQLKVKDRILENI-SLSVKKL--QS--YFAACE-DETPAIRNHDRVLQRLCEHLDHALLYGLQDI 60

  Fly   332 KKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQAL 396
            ..|       .|.|   |.|:  ..::....:.:|..:.|::||:||||.:||.:..|..||: |
Zfish    61 SSG-------YWVL---VLHF--TRREAIRQIEELQHIATNLGRSRAWLYLALNESSLESYLR-L 112

  Fly   397 IEHREDSLFDYYEPHALMMS-DEIVVIMGILVGLNVIDCNLCVKEEDLD---------SQQGVID 451
            .|..:..|..||..:||:.| |.:.:.:.::.||..|..||.:....||         ..|.::|
Zfish   113 FEENQGLLQKYYYKNALVCSHDHLTLFLTLVSGLEFIRFNLELDVPYLDVAPYMPEYYKPQNLLD 177

  Fly   452 F--------SLYLRS----SSRNAD-----AAP--ED-----------SAPPA------LLD--- 477
            |        ||.|.|    :|.|.:     .||  ||           |.|.|      |.|
Zfish   178 FEERLPSSDSLSLHSFTSLTSTNLEWDDSAIAPSSEDYDFGDIFPVLQSLPSADWEEGDLTDPVS 242

  Fly   478 ---ATGQGNMIAVLD-----------------------QKNYIEELNRHLNATVGNLQAKVESLT 516
               ::|......|.|                       |..:.|:.:.:.:|.|..:.......:
Zfish   243 GPRSSGSDPQTVVSDCVVVKASAGTIRTTSLSRSPTFRQNPFTEDSDTNTSADVTPVHIASRHTS 307

  Fly   517 TTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKD----------------- 564
            ||.    ||..|....|..:    :..|:..........||..||:::
Zfish   308 TTG----EDAEITSTELEVI----RMARRRKPGKKRRGRGSSVSSEQNVISPEVTDECLQIVVER 364

  Fly   565 ------------------KEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQ 611
                              ...|||.|...||:..|.|.|..|:  |...:|.:|..:.:.:.|..
Zfish   365 DVTVNHITVDSRVPLERADSTASEPLRNGRREGEEEEPETGLR--LPEMTDTSMDNVGQPLREVM 427

  Fly   612 DTIVSLRRQLDDIKQI--------NLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEK 668
            |.:.......|..::|        |.:.:|  :|........::...:..:...|......|...
Zfish   428 DRLNGSLDAEDGAEEICTAHDGPPNQQPFR--EDAGGEPPDPSDGFLQAPLPPADFYCFTSQSPD 490

  Fly   669 KWS-----HDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRIE-REWRISLQEKELKLKE-- 725
            ..:     ||.:..||         ...|..|.|....||||:... ::..|:::..|.||.:
Zfish   491 PAASGGGRHDSAGHGE---------PQDVPVSNEDEGEAEAEAAAAGQDPSIAIETSEKKLSQTE 546

  Fly   726 ---------------KIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVS 775
                           |:.|....|..:...:|...:|   ...||......:..|:.|.:.|:..
Zfish   547 EDDEDATQSSHAAEFKVDNNHLLLLMIHVFRENEEQL---FKMVRMSTGHMEGDLQPLYLLLTDC 608

  Fly   776 KLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVG-------SPGIWAPDSIATHCTACEREFNL 831
            .:.:            |..|:|:...::.|||.       |.|: ...:|...||...|:|.|
Zfish   609 YIYL------------LRKGAAEKPYSVEEAVSYNELDYISVGL-HQQTITLVCTNRRRQFLL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	36/124 (29%)
		CASP_C	495..>634	CDD:285395	32/181 (18%)
		FYVE_RUFY1_like	813..874	CDD:277261	6/19 (32%)
plekhm2	NP_001124255.1	RUN	44..156	CDD:295434	36/124 (29%)
		PH_SKIP	748..850	CDD:270119
		PH	748..848	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840