Protein Alignment CG31064 and Rufy1

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_001094197.1
• Gene: Rufy1 / 360521
• RGDID: 1305099
• Length: 711
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 271/674 - (40%)
• Similarity: 400/674 - (59%)
• Gaps: 93/674 - (13%)

  Fly   246 SKRFSG-LSTGSGSG-------GNAGGGGGLDITDNARDTAEI--ERSNLVNICKLVVKELLEQS 300
            ::|.:| ||...||.       |:.|||||    :.|....::  ||:||:::.||.:|.||:.:
  Rat    74 ARRATGNLSASCGSALRAAAGLGDGGGGGG----ERAASKGQMMEERANLMHMMKLSIKVLLQSA 134

  Fly   301 LRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRD 365
            |..||.||:||.|||.||:|:||.|.|||:.||..:|..|..:..|:.||..||||.||..|||:
  Rat   135 LSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRN 199

  Fly   366 LPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLN 430
            ||.::|.:||.||||.:|||||||:|||:.||:::. .|.::|||.||||.:|.:||:|:|||||
  Rat   200 LPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKH-LLSEFYEPEALMMEEEGMVIVGLLVGLN 263

  Fly   431 VIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIE 495
            |:|.|||:|.||||||.|||||||||: ..::.|:..|..            .:..|||||||:|
  Rat   264 VLDANLCLKGEDLDSQVGVIDFSLYLK-DVQDLDSGREHE------------RITDVLDQKNYVE 315

  Fly   496 ELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGS 560
            ||||||:.|||:||.|::.|..||:.::|:|:.|.:.:.:||.|.|.:|:........|..|...
  Rat   316 ELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEI 380

  Fly   561 SDKDKEKASE------------------ELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDI 607
            :.:|.:...|                  :|.||::...||||||:||:.:|.|.::||||||||.
  Rat   381 TKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDT 445

  Fly   608 HEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLE----- 667
            ||||||:|:||:||:::|.|||:|:.|:|..::||..|.|.:...|.:...:.|::.|:|
  Rat   446 HEKQDTLVALRQQLEEVKAINLQMFHKVQSAESSLQQKDEAIASFEGKTTQVMSSMKQMEERLQQ 510

  Fly   668 ----KKWSHDKS-NLGEILKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQ-----EKELK 722
                ::.:.::| .|.:.|......|..|::...::.:..|.|.:.|:|.|.:||     ||:..
  Rat   511 AERARQGAEERSYKLQQELSGRVSALQLQLSQLRDQCSGLEKELKSEKEQRQTLQRELQHEKDTS 575

  Fly   723 --LKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQ 785
              |:.::..::|..|||.|.::.    ||:|.||   ..|.:..|:|:|:.||.||||:.::::.
  Rat   576 CLLQTELQQVEGLKKELRELQDE----KAELRKV---CEEQEQALQEMGLHLSQSKLKMEDIKEV 633

  Fly   786 ERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACS 850
            .:    .|.|..               |..|..||||..||::|:::|||||||:||.|||..||
  Rat   634 NK----ALKGHT---------------WLKDDEATHCKQCEKDFSISRRKHHCRNCGHIFCNTCS 679

  Fly   851 EHTLPLLNAQGQPGKPVRVCDNCY 874
            .:.|.|   ...| |||||||:|:
  Rat   680 SNELAL---PSYP-KPVRVCDSCH 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	84/154 (55%)
		Smc	<562..>807	CDD:440809	86/279 (31%)
		FYVE_RUFY1_like	813..874	CDD:277261	33/60 (55%)
Rufy1	NP_001094197.1	RUN_RUFY1	115..270	CDD:439056	85/155 (55%)
		SMC_prok_B	<376..>632	CDD:274008	85/262 (32%)
		FYVE_RUFY1	637..707	CDD:277297	36/82 (44%)