Protein Alignment CG31064 and zfyve26

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: XP_003199781.2
• Gene: zfyve26 / 324565
• ZFINID: ZDB-GENE-030131-3286
• Length: 2552
• Species: Danio rerio
• Alignment Length: 1125
• Identity: 224/1125 - (19%)
• Similarity: 374/1125 - (33%)
• Gaps: 368/1125 - (32%)

  Fly    29 RIKSSSLATGSSASGSSSKPLRSAVKTPTSGSATSLSSGTMAAKKAPQTGQQQVGKSA----KSA 89
            :|:|.||:|    |.|||:.|                 ||:.|..|   |:.::|.|:    ||.
Zfish   845 KIESQSLST----SSSSSEGL-----------------GTLGATPA---GRTRMGSSSRLTLKSI 885

  Fly    90 TAATPTGTTATAIGATATTRAQAAAAK-----------------SQKGQNPPSQQVQPKQQPP-- 135
            .:|...|....:|...| .|..:..::                 |.....|..:::.|.....
Zfish   886 GSAAAAGMAFYSISDVA-DRLMSTPSRPIPCLEDSYWLSQCTIDSPDFVRPLVEELSPAAMAAFD 949

  Fly   136 ------QPQQTQQQPLVLQQQQASNSSNTIAL---PKASHANTSEELAGGVQDTIYLCNFRVSVD 191
                  |..:|.:|.|...:::.|:......:   ||..|||........:|....:.| :.|.:
Zfish   950 LSCCQCQLWKTSRQLLETAERRLSSFLEARGVRVDPKVPHANGIRGFPSVLQQISKILN-KTSTN 1013

  Fly   192 GEWLCLKELQDIDVAGGTGNQ-----AAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSG 251
                  |.:...| ..|..|.     .....|.|....|:.|   ..:..:..:.::|.......
Zfish  1014 ------KGMSKTD-CNGEENAVCSPFGCSAQEVLLSCHSTLT---EESITIQQNLNQRLEVTLQT 1068

  Fly   252 LSTGSGSGGNAGGGGGLDITDNARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDS------D 310
            ||:.:.:..::..|..| :|..| :.|.:::|.|  .|. .|:..::|.|:|   ||.      |
Zfish  1069 LSSATNTSVDSLVGSNL-LTALA-EQAALKQSEL--DCH-PVRTAMKQLLQY---LDQLCPLVPD 1125

  Fly   311 HLP-----LQHFF---IVIEHVL--GHGLRPKKGLLGPRKELWDLLQS----VEHYCPEAQDITA 361
            ..|     ::.||   .|:..||  ..|...:..::.....|..||||    :.|...:.|....
Zfish  1126 GAPDRPDYIRSFFDYVNVLASVLVRSLGSEDQSTVVKLGNPLLLLLQSPAQLLSHLLFDRQVSPD 1190

  Fly   362 SVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGIL 426
            .|..|                 |.|::|...:|.::..|.......::..|:..|..:
Zfish  1191 RVLSL-----------------LQQERLRLSVQQVVVQRCCETLPLWDSRAVNFSQRV------- 1231

  Fly   427 VGLN----------------VIDCN--------LCVKEEDLDSQQGVIDFSLYLRSSSRNADAAP 467
            .|||                ..||:        ....:...:|:..|.|.|....|.| .:..:|
Zfish  1232 SGLNGGAFCPASIASILQQYAQDCSPSLDLSDPTTTSDPSSESEVSVEDVSAASTSLS-TSPPSP 1295

  Fly   468 EDSAPP-----------------------ALLDAT--------------------GQGNMIAVLD 489
            ..|:|.                       |.|.|:                    |.|...||||
Zfish  1296 SSSSPSSSFLLTPSALSFLKSRSPLVAALACLSASRGGVTRVTSSGWSGLPSYFRGSGRKEAVLD 1360

  Fly   490 QKNYIEELNRHLNATVGN-------LQAKVESLTTTNALMKEDLAIA---------------RNS 532
            .    |:::|...|.:.|       |:...|.:...:....|.|.:|               .|:
Zfish  1361 G----EQISREGEALLKNFPILRMYLRTMAEPVLGVSLEADEGLGVALCGKPVVGMLFSGLQGNA 1421

  Fly   533 LLALQAENQAMRQSTSAGDNN------------STGSGGSSDK-------DKEKASEELVEERRK 578
            ..|:.||  |.:|:.:.||.|            .:..|...||       .:..::|:|.  |.:
Zfish  1422 AQAMAAE--AFQQALNNGDLNRALDLLELYAQPCSQEGALRDKLLAFTALQESSSAEQLF--RVR 1482

  Fly   579 NSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLT 643
            :.||...:.||...:......:.||...:.: |:|...||.||...|| .|:||:::...:.||.
Zfish  1483 DWELRGRVVLQGLDRWPLQQCLDLLHFCLSD-QNTKDPLREQLQQRKQ-ELDMYQRMLRLQPSLP 1545

  Fly   644 HKT-----ELMTK---------LEVQKEDMA-------STIDQ-------------LEKKWSHDK 674
            .:|     |..||         ||.::.::.       |..||             ||...:.:.
Zfish  1546 WETWQELREESTKNPESVFSQMLEAREFELCAQWVQLYSVSDQSGMQLQTEHLLYLLEHNHTEEA 1610

  Fly   675 SNLGEILKTT----------------------SQTLT----TQVTASEERAARA-EAESRI---- 708
            ..|.|.|..:                      |..||    :|:|.:..|...| ...|::
Zfish  1611 FQLLEALSDSMGLEVSERALDRRPGLAACHFLSDYLTLHFQSQMTPARRRHIHALHLGSKVLLTL 1675

  Fly   709 ----EREWRISLQEKELKLKEKIANLQ--------GCLKELSEEKERN-------------GKLK 748
                .:::...|.:..|.|::.:.||:        ..|:.|...::..             .:..
Zfish  1676 PEASRQDYFSLLSDPLLMLEQMLMNLKVDWAAVAITTLRSLLLAQDAGITTQHIDTLLADYARKA 1740

  Fly   749 ADLDKVRTQWSEAQT--TLEELGIQLSVSKLKVSE-------------MQ--DQERRQRQLLSGS 796
            .|......:||.:.:  :|::..:|....:...|.             ||  ..|||.      |
Zfish  1741 LDFPYAPREWSRSDSVISLQDAFLQCPAQESCPSSPSHTPPPSTGGTPMQTPSSERRP------S 1799

  Fly   797 AQSLQAM------PEAVGSPGIWAPDSIATHCTACERE-FNLTRRKHHCRSCGEIFCKACSEHTL 854
            .:.::.:      ||.......|.||.....|..|:|| |.:..|:||||.||.:.|.:||...:
Zfish  1800 GKKIRPLATPFTPPEKTPDRKDWIPDHKQHICMVCQRERFTMFNRRHHCRRCGRLVCHSCSSKKM 1864

  Fly   855 PLLNAQGQPGKPVRVCDNCY 874
            .:....    :||||||.||
Zfish  1865 AVAGFD----EPVRVCDQCY 1880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	38/198 (19%)
		Smc	<562..>807	CDD:440809	67/364 (18%)
		FYVE_RUFY1_like	813..874	CDD:277261	24/61 (39%)
zfyve26	XP_003199781.2	FYVE_ZFY26	1822..1881	CDD:277263	26/63 (41%)