DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and Rundc3b

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001334240.1	Gene:	Rundc3b / 242819	MGIID:	2685286	Length:	457	Species:	Mus musculus

Alignment Length:	463	Identity:	129/463 - (27%)
Similarity:	211/463 - (45%)	Gaps:	76/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 SKRFSGLSTGSGSGGNAGGGGGLDITDNARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSD 310
            |:...||   |||.|..|||||.. :.:||:.| :||.||:.:|:..||.|:::|.  ...:|..
Mouse     3 SRSLGGL---SGSRGGGGGGGGKK-SLSARNAA-VERRNLITVCRFSVKTLIDRSC--FETIDDS 60

  Fly   311 HLPLQHFFIVIEHVLGHGLRPKK---GLLGPRKELWDLLQSVEHYCPE-AQDITASVRDLPTVRT 371
            .....:|..|:|.:|.|.|:.:.   |...|| ..||.::..   |.: :|:...|:.::..|.:
Mouse    61 SPEFNNFAAVLEQILSHRLKGQVTWFGYESPR-SFWDYIRVA---CRKVSQNCICSIENMENVSS 121

  Fly   372 HIGRARAWLRIALMQKKLSDYLQ-ALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCN 435
            ...:.|||:|:|||:|.||:|:. ||.:.:....|  ||..|:::.:|..::.|:|:|||.||.:
Mouse   122 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRF--YEDGAIVLGEEANMLAGMLLGLNAIDFS 184

  Fly   436 LCVKEEDLDSQ-QGVIDFSLYLR------------------SSSRNADAAPEDSAPPALLDATGQ 481
            .|:|.|.||.. ..|||::.||:                  .||.:..:.||:..||.:||....
Mouse   185 FCLKGEGLDGTFPAVIDYTPYLKFEQSSDSISSDEEELRTFGSSDSESSTPENVGPPLILDENTW 249

  Fly   482 GNMI--------AVLDQKNYIEELNR----HLNATVGN---LQAKVESLTTTNALMKEDLAI--- 528
            .|..        ..|:||.|:|||.|    .|:.:|..   |..::|.....:.|.||.|..
Mouse   250 FNKCKRVRQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIV 314

  Fly   529 -ARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSL 592
             .::.|..|:..:...||..:|.......|.|:.|.: ..|.:.|:..:......:|..:....|
Mouse   315 ELQDQLTVLKNNDLRSRQELTAHLTKQWPSPGALDVN-AVALDTLLYRKHNKQWYDKSYQSLDQL 378

  Fly   593 KAESDMAMKLLEKDIHE----KQDTIVSLRRQLDDIKQI--------NLEMYRKL-----QDCKA 640
            .||..::...|:....:    |||::..:....:|...:        ::..|:.|     .||.|
Mouse   379 SAEVSLSQASLDPSHSQEGDGKQDSLNFIGEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDCLA 443

  Fly   641 SLTHKTEL 648
            |.|  |||
Mouse   444 SPT--TEL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	41/127 (32%)
		CASP_C	495..>634	CDD:285395	32/161 (20%)
		FYVE_RUFY1_like	813..874	CDD:277261
Rundc3b	NP_001334240.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740