Protein Alignment CG31064 and ZFYVE26

DIOPT Version :9

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: XP_016876613.1
• Gene: ZFYVE26 / 23503
• HGNCID: 20761
• Length: 2545
• Species: Homo sapiens
• Alignment Length: 1266
• Identity: 244/1266 - (19%)
• Similarity: 402/1266 - (31%)
• Gaps: 496/1266 - (39%)

  Fly    19 NNLSSTSGSGRIKSSSLATGSSASGSSSK-----------PLRSAVKTPTSGSATSLSSGTMAAK 72
            :.:||.|...:.|..|.:...|..|..|:           ..|..|.|....|....|.....|.
Human   697 DEISSRSPPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPAT 761

  Fly    73 KAPQTGQQQVGKSAKSATA------ATPTGTTATAIGATATTRAQAAAAKSQKGQNPPSQQVQPK 131
            :.|...:   |:..:.:.|      :.|:..:.::..:|:|:....:|   ..|:|....::.|.
Human   762 RHPSLRR---GRRTRRSQADGRDRGSNPSLESTSSELSTSTSEGSLSA---MSGRNELHSRLHPH 820

  Fly   132 QQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVS-VDGEWL 195
                  .|:...|::....::..:|..:      ..|.:|     ....::..|.:.| ..||.:
Human   821 ------PQSSLIPMMFSPPESLLASCIL------RGNFAE-----AHQVLFTFNLKSSPSSGELM 868

  Fly   196 CLKELQDIDVAGGTGNQAAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSGLSTGSGSG- 259
            .::..|::.      .:.||...|:.          ..|.:.|||:.:|         ||||..
Human   869 FMERYQEVI------QELAQVEHKIE----------NQNSDAGSSTIRR---------TGSGRST 908

  Fly   260 ----GNAGGGGGL-----DITDNARD----------------TAEIE-----RSNLVNI------ 288
                |:|...|.:     |:||...:                ||.:|     |..|.::
Human   909 LQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMA 973

  Fly   289 --------CKL--VVKELLE-------QSL-RYGRMLDSDHLPL-----QHFFIVIEHV---LGH 327
                    |:|  ..|:|||       .|| |.||.:  ||:.|     :.|.:|::.:   |.:
Human   974 AFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRI--DHVLLNADGIRGFPVVLQQISKSLNY 1036

  Fly   328 GLR----------PKKGLLGPRKELWDLLQ----SVEHYC--------PEAQDITASVR---DLP 367
            .|.          .:||...||..:.:|||    |:...|        .:...:..|:|   :||
Human  1037 LLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELP 1101

  Fly   368 TVRT------------HIGRARA---WLRIALMQKKLS----------DY----------LQALI 397
            ..||            ....|.|   .::..|:||.|.          ||          |.|::
Human  1102 EPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVL 1166

  Fly   398 EHREDSLFDYYE-----PHALMMSDEIVVIMGIL------------------VGLNV----IDC- 434
            .....|..|:.|     |..|:......::..:|                  :.|:|    :.|
Human  1167 LQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCC 1231

  Fly   435 ----NLCVKEEDLDSQQ--------GVI----------DFSLYLRSSSRNAD---------AAPE 468
                .||...:   |||        |.:          |..|...||.|..:         ::|.
Human  1232 CEPLALCSSRQ---SQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPR 1293

  Fly   469 DSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDL------- 526
            ||:.|||..:.     :|.|..::       .|.|||..|.|......:..:|..::|
Human  1294 DSSLPALTSSA-----LAFLKSRS-------KLLATVACLGASPRLKVSKPSLSWKELRGRREVP 1346

  Fly   527 ----AIAR--------------------------------------------------NSLLALQ 537
                .:||                                                  :|.:||.
Human  1347 LAAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALD 1411

  Fly   538 AENQAMRQSTSAGDNNS----TGSGG------SSDKDKEKASEELVEERR-------KNSELEKE 585
            ..::|..:|..|.|.:.    |...|      ||.||...:.....::..       |::.|...
Human  1412 VLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSR 1476

  Fly   586 LKLQVSLKAESDMAMKLLEKDIHEKQDTIV------SLRRQLDDIKQINLEMYRK---------- 634
            |.||...:...:..:::|...|   .||.|      .|:|:|.:     |::|:|
Human  1477 LALQFVDRWPLESCLEILAYCI---SDTAVQEGLKCELQRKLAE-----LQVYQKILGLQSPPVW 1533

  Fly   635 -----LQDCKASLTHKTELMTKLEVQKEDMAS--------------------TIDQLEKKWSHDK 674
                 |:.|... ...|.:...||.|:.::..                    .:..||:: .|||
Human  1534 CDWQTLRSCCVE-DPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERR-DHDK 1596

  Fly   675 S--NLGEI------LKTTSQT----------------LTT----QVTASEERAARA-EAESRIER 710
            :  .|..|      |:.|.|:                |||    |:||...|..:| ...|:|
Human  1597 ALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKI-- 1659

  Fly   711 EWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQ-------WSEAQTTLEEL 768
              .::|.|:.   :...::|......:.|:...|  :|.|...|..|       ..|...|::|:
Human  1660 --LLTLPEQH---RASYSHLSSNPLFMLEQLLMN--MKVDWATVAVQTLQQLLVGQEIGFTMDEV 1717

  Fly   769 GIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAV--------------------GSPGI- 812
            ...||....|..:....:|.:|...|.|..|:..:.|.|                    ..|||
Human  1718 DSLLSRYAEKALDFPYPQREKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGIS 1782

  Fly   813 --------------------------------WAPDSIATHCTACERE-FNLTRRKHHCRSCGEI 844
                                            |.||...:.|..|.|| |.:..|:||||.||.:
Human  1783 SIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRL 1847

  Fly   845 FCKACSEHTLPLLNAQGQPGKPVRVCDNCYA 875
            .|.:||...:.:   :|....|.||||.||:
Human  1848 VCSSCSTKKMVV---EGCRENPARVCDQCYS 1875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	40/217 (18%)
		CASP_C	495..>634	CDD:285395	38/222 (17%)
		FYVE_RUFY1_like	813..874	CDD:277261	24/61 (39%)
ZFYVE26	XP_016876613.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930