DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31064 and PLEKHM2

DIOPT Version :10

Sequence 1:NP_001287560.1 Gene:CG31064 / 43277 FlyBaseID:FBgn0051064 Length:877 Species:Drosophila melanogaster
Sequence 2:XP_016856246.1 Gene:PLEKHM2 / 23207 HGNCID:29131 Length:1032 Species:Homo sapiens


Alignment Length:623 Identity:119/623 - (19%)
Similarity:203/623 - (32%) Gaps:197/623 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   310 DHLP--------LQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDL 366
            |.:|        ||.....::|.|.:||:...      ...|.|   |.|:  ..::....:..|
Human    43 DEIPAIRNHDKVLQRLCEHLDHALLYGLQDLS------SGYWVL---VVHF--TRREAIKQIEVL 96

  Fly   367 PTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMS-DEIVVIMGILVGLN 430
            ..|.|::||:||||.:||.:..|..||: |.:.....|..||..:||:.| |.:.:.:.::.||.
Human    97 QHVATNLGRSRAWLYLALNENSLESYLR-LFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLE 160

  Fly   431 VIDCNLCVKEEDLDS--------------QQGVIDFSLYLRSSSRNADAAP-------------- 467
            .|...|     |||:              .|.::||...|.||...:|:..              
Human   161 FIRFEL-----DLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEW 220

  Fly   468 EDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNS 532
            :|||.....:....|::...:......:..:..|..||...::....||::.|..:.        
Human   221 DDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRS-------- 277

  Fly   533 LLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELE-----KELKLQVSL 592
              ..|.:|....:......::.|....::.::||:|  :.::.....:|||     |:.|:....
Human   278 --PTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEA--QALDPPDACTELEVIRVTKKKKIGKKK 338

  Fly   593 KAESDMAMKLLEKDIHEK----------QDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTE 647
            |:.||.....|.....:|          ::...||.|...|..   |...::..:..:|.|..:|
Human   339 KSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTM---LASPQEEGEGPSSTTESSE 400

  Fly   648 LM-----------TKLEVQKEDMASTIDQLE-----KKW-------------------------- 670
            ..           |.:|...:.::..||||.     ..|                          
Human   401 RSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLC 465

  Fly   671 ----------------------------SHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESR 707
                                        .||.:.||:.|...|   :.:....||.....|.::.
Human   466 DFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQPLHVPS---SPEAAGQEEEGGGGEGQTP 527

  Fly   708 IEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQL 772
                                       :.|.:......:|:|.|..||    |...:..|.|.|.
Human   528 ---------------------------RPLEDTTREAQELEAQLSLVR----EGPVSEPEPGTQE 561

  Fly   773 SVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSP 810
            .:.:||    :||   ....||.:..|  .:.|..|||
Human   562 VLCQLK----RDQ---PSPCLSSAEDS--GVDEGQGSP 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31064NP_001287560.1 RUN_RUFY1_like 281..436 CDD:439043 37/134 (28%)
Smc <562..>807 CDD:440809 55/329 (17%)
FYVE_RUFY1_like 813..874 CDD:277261
PLEKHM2XP_016856246.1 RUN_PLEKHM2 34..166 CDD:439042 37/134 (28%)
PH_SKIP 786..888 CDD:270119
Blue background indicates that the domain is not in the aligned region.

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