Protein Alignment CG31064 and PLEKHM2

DIOPT Version :9

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: XP_016856246.1
• Gene: PLEKHM2 / 23207
• HGNCID: 29131
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 119/623 - (19%)
• Similarity: 203/623 - (32%)
• Gaps: 197/623 - (31%)

  Fly   310 DHLP--------LQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDL 366
            |.:|        ||.....::|.|.:||:...      ...|.|   |.|:  ..::....:..|
Human    43 DEIPAIRNHDKVLQRLCEHLDHALLYGLQDLS------SGYWVL---VVHF--TRREAIKQIEVL 96

  Fly   367 PTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMS-DEIVVIMGILVGLN 430
            ..|.|::||:||||.:||.:..|..||: |.:.....|..||..:||:.| |.:.:.:.::.||.
Human    97 QHVATNLGRSRAWLYLALNENSLESYLR-LFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLE 160

  Fly   431 VIDCNLCVKEEDLDS--------------QQGVIDFSLYLRSSSRNADAAP-------------- 467
            .|...|     |||:              .|.::||...|.||...:|:..
Human   161 FIRFEL-----DLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEW 220

  Fly   468 EDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNS 532
            :|||.....:....|::...:......:..:..|..||...::....||::.|..:.
Human   221 DDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRS-------- 277

  Fly   533 LLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELE-----KELKLQVSL 592
              ..|.:|....:......::.|....::.::||:|  :.::.....:|||     |:.|:....
Human   278 --PTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEA--QALDPPDACTELEVIRVTKKKKIGKKK 338

  Fly   593 KAESDMAMKLLEKDIHEK----------QDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTE 647
            |:.||.....|.....:|          ::...||.|...|..   |...::..:..:|.|..:|
Human   339 KSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTM---LASPQEEGEGPSSTTESSE 400

  Fly   648 LM-----------TKLEVQKEDMASTIDQLE-----KKW-------------------------- 670
            ..           |.:|...:.::..||||.     ..|
Human   401 RSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLC 465

  Fly   671 ----------------------------SHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESR 707
                                        .||.:.||:.|...|   :.:....||.....|.::.
Human   466 DFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQPLHVPS---SPEAAGQEEEGGGGEGQTP 527

  Fly   708 IEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQL 772
                                       :.|.:......:|:|.|..||    |...:..|.|.|.
Human   528 ---------------------------RPLEDTTREAQELEAQLSLVR----EGPVSEPEPGTQE 561

  Fly   773 SVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSP 810
            .:.:||    :||   ....||.:..|  .:.|..|||
Human   562 VLCQLK----RDQ---PSPCLSSAEDS--GVDEGQGSP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	34/123 (28%)
		CASP_C	495..>634	CDD:285395	27/153 (18%)
		FYVE_RUFY1_like	813..874	CDD:277261
PLEKHM2	XP_016856246.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840