DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31064 and Zfyve28

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001015039.1	Gene:	Zfyve28 / 231125	MGIID:	2684992	Length:	905	Species:	Mus musculus

Alignment Length:	874	Identity:	161/874 - (18%)
Similarity:	285/874 - (32%)	Gaps:	323/874 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 RSNLVNICKLVVKELLEQS-------LRYGRMLDSDHLPLQHFF---------IVIEHVL-GHGL 329
            :.|::||...:::|.:.|.       :::...:..|:|..|.:|         |::...| ...:
Mouse    60 QDNVLNIINQIMEECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAM 124

  Fly   330 RPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRD--LPTVRTHIGRARAWLR---IALMQKKL 389
            ||.      .||   |.:|:|       |:..::||  |..:.|:..:.|..||   :...:.:|
Mouse   125 RPL------AKE---LTRSLE-------DVRGTLRDQALRDLNTYTEKMREALRRFDVLFAEFEL 173

  Fly   390 SDYLQALI---EHRE-------------------------DSLFDYYEPHALMMSDEIVVIMGIL 426
            | |:.|::   ..||                         ..:.|.|||..:.....:.::.|::
Mouse   174 S-YVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFTIPRLAIVCGLV 237

  Fly   427 V---------------------------------------GLNVIDCNLCVKEEDLDSQQGVIDF 452
            |                                       .|:.::.:|||.:          |.
Mouse   238 VYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQALTEEELHTLERSLCVSQ----------DV 292

  Fly   453 SLYLRSSSRNADA-APEDSA--PPALLDATGQGNMIAVL-------DQKNYIEELNRHLN----- 502
            .|.:|:.::...| ||..||  ||....:....|..|.|       ||:  :|||:|.::
Mouse   293 ELPIRADTQAPSALAPTFSASLPPEETLSASANNPEAELACSMQYDDQE--LEELSRMVHRAGDE 355

  Fly   503 ---------------------------ATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAEN 540
                                       |:....:.|..|.........:|:.:..:   ..:.|:
Mouse   356 MSSLLSPPSACQSPAHRPGSEASPRGEASPARARLKSGSDEEERVFFMDDVEVTES---PARPES 417

  Fly   541 QAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELE-KELKL---------------- 588
            .......:.|:....|..|.|.:...:|...:.||...|:.:| .::||
Mouse   418 PGNTFELTQGNAQQRGQDGQSGEVGVEAPALVKEEDWSNNNVEGDKIKLASLMGSTSCSCLDSQL 482

  Fly   589 -----QVSLK--------AESDMAMKLLEKDIHE-----KQDTIVSLRR-------QLDDIKQIN 628
                 :||.:        |.....|||....|..     .||:.|:.:.       .|:...:..
Mouse   483 YLDGWEVSAEDAETAEMIAHRTGGMKLSATVIFNPKSPTSQDSAVAAQEAPGHGTSPLEPRAEGT 547

  Fly   629 LEMYRKLQDCKAS-LTHKTELMTKLEVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQV 692
            .:...||.....: |.|...........::|   .:::|     .:|...|.::..::.:::...
Mouse   548 GDNSHKLSTTATNCLLHSCVCCGSCGDSRDD---AVERL-----REKCGPGSVISASNPSVSLAK 604

  Fly   693 TASEERAARAEAES---RIEREWRISLQEKELKLKEK-IANLQGCLKELSEEKERNGKLKADLD- 752
            ...:|.....||:.   .:..|...:.||.:.....| :|:..|...:.:...:..|::|...:
Mouse   605 GGDKEPERIDEAQPSDVTLPAEDASNRQEPKAPASSKCLAHTSGPQVDTASRLQGEGEVKGQPEP 669

  Fly   753 KVRTQWSE--------------AQT---------------TLEELGIQLSVSKLKVSEMQDQERR 788
            :.|.|..|              |||               :|:...:.::.:.:.|:.|..:|:.
Mouse   670 EARKQDPEKSPVVSGDSPRGDVAQTEHQHLLGSSSTVGSCSLDNTRLDVATAAMPVTPMATREKI 734

  Fly   789 QRQL-------------LSGSAQSLQA-------------------------------------- 802
            :.:.             :||.|..||.
Mouse   735 RSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLKKVTQTLRS 799

  Fly   803 --------MPEAVGS--------------PGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIF 845
                    ..|.|.|              |..|.||.....||:|:..|.:.||||||||||:||
Mouse   800 AALEDCALCQETVSSSELAAKTRDGDFEDPPEWVPDEACGFCTSCKAPFTVIRRKHHCRSCGKIF 864

  Fly   846 CKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
            |..||.|:.| |...||. ||||||.:||
Mouse   865 CSRCSSHSAP-LPRYGQV-KPVRVCTHCY 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	33/204 (16%)
		CASP_C	495..>634	CDD:285395	31/212 (15%)
		FYVE_RUFY1_like	813..874	CDD:277261	33/60 (55%)
Zfyve28	NP_001015039.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..441		9/89 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..552		4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..691		15/101 (15%)
		FYVE_LST2	828..892	CDD:277270	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870