DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31064 and RUFY3

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_011530052.1	Gene:	RUFY3 / 22902	HGNCID:	30285	Length:	680	Species:	Homo sapiens

Alignment Length:	753	Identity:	272/753 - (36%)
Similarity:	402/753 - (53%)	Gaps:	132/753 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PKASHANTSEELAGGVQDTIYLCNFRVSVDGEWLCLKELQDIDVAGGTG--NQAAQTSEKLAGGS 224
            |.|...:.|||.|.|               |||  ..|......||||.  .:|.......||.|
Human     8 PTAGAESCSEEPARG---------------GEW--RPEEPRRAPAGGTDREGEAGPPPASPAGQS 55

  Fly   225 SSQT-----------GGFGSNYNVGSSSSKRNSKR----------FSGLSTGSGSGGNAGGGGGL 268
            ...:           |..|:.:.|.....::.|.|          |..||..||.||::|.|
Human    56 EPDSPVAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTPPSPGSPLPFLLLSYPSGGGGSSGSG--- 117

  Fly   269 DITDNARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKK 333
              ..:.......||.||:|:.||.:|.|:|.:|..||.||||:.|||.||:|:||.|.|||:.||
Human   118 --KHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180

  Fly   334 GLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIE 398
            ..||..|..|..|:.||...|||.:|||||:|||.::|.:||.|||||:||||||||:|::|||
Human   181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI- 244

  Fly   399 HREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLR--SSSR 461
            ::::.|.::|||:||||.:|..:|.|:||||||||.|.|:|.||||||.||||||:||:  :||:
Human   245 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSK 309

  Fly   462 NADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDL 526
            ..:               |.|.:.|:||||||:|||||||||||.||||||::|..:|..:.|:|
Human   310 GTE---------------GDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEEL 359

  Fly   527 AIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKE-----KASEELVEERRKNSELEKEL 586
            |:|.|.::.||.|.:.:::.:|. ...|...|...|:..|     :|.:.|.||.:...::||||
Human   360 AVANNRIITLQEEMERVKEESSY-ILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKEL 423

  Fly   587 KLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTK 651
            ::|:|::.|.::|||:||||:.||||.:||||:||||::.:..|:..|||.....:..|:||.::
Human   424 EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSR 488

  Fly   652 LEVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRI-EREWRIS 715
            ||.:...||:||.|||::                      :..:|.....||.::|: ::::...
Human   489 LEEKTNQMAATIKQLEQR----------------------LRQAERSRQSAELDNRLFKQDFGDK 531

  Fly   716 LQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQT----TLEELGIQL---- 772
            :...:|:::|..........||.:||||..:....:....:|.||::.    .::|..::|
Human   532 INSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPL 596

  Fly   773 -SVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKH 836
             ...:|:...|.:|:    |||      |...|:.               |..|:.:.:||  |:
Human   597 EESHRLQPHPMDEQD----QLL------LSEKPQL---------------CQLCQEDGSLT--KN 634

  Fly   837 HCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874
            .|::|...||.|||.:.|||.::.    |..|||:.|:
Human   635 VCKNCSGTFCDACSTNELPLPSSI----KLERVCNPCH 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	70/122 (57%)
		CASP_C	495..>634	CDD:285395	63/143 (44%)
		FYVE_RUFY1_like	813..874	CDD:277261	19/60 (32%)
RUFY3	XP_011530052.1	Cytochrom_B558a	<21..64	CDD:282843	13/59 (22%)
		RUN	163..286	CDD:280855	70/123 (57%)
		Apolipoprotein	334..507	CDD:279749	72/195 (37%)
		DUF4763	402..558	CDD:292582	55/177 (31%)
		FYVE_RUFY3	621..668	CDD:277283	19/67 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149901
Domainoid	1	1.000	148	1.000	Domainoid score	I4468
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329099at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40735
orthoMCL	1	0.900	-	-		OOG6_103035
Panther	1	1.100	-	-	O	PTHR45956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5167
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.740