DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31064 and Zfyve26

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_017170500.1	Gene:	Zfyve26 / 211978	MGIID:	1924767	Length:	2546	Species:	Mus musculus

Alignment Length:	952	Identity:	201/952 - (21%)
Similarity:	307/952 - (32%)	Gaps:	237/952 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GSGRIKSS----------SLATGSSASGSS--------SKPLRSAVKTPTSGSATSLSSGTMAAK 72
            |.|..:||          ||.....||.:|        .:.||.|:..|.|.|.........||:
Mouse  1044 GGGAPRSSISELLQMCWPSLTEDCVASHTSLSQQLEQALQSLREALALPESKSTPLSCLVEQAAQ 1108

  Fly    73 KAPQTGQQQVGKSA----KSATAATPTGTTAT-AIGATATTRAQAAAAKSQK-GQNPPSQQVQPK 131
            |||:.....|...:    |:....||.|...| .:||..:..:..||...:. ..:|...:|:
Mouse  1109 KAPEAEAHPVHIQSQLLQKTLGRQTPAGHRQTDYVGAFFSYCSSLAAVLLRSLSSDPDHVEVR-- 1171

  Fly   132 QQPPQPQQTQQQPLVLQQQQASN------------SSNTIALPKASHANTSEELAGGVQDTIYLC 184
                     ...|.||.||.:|.            .....||....|.|.|      |...|..|
Mouse  1172 ---------VGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAQEHLNLS------VPQVIVSC 1221

  Fly   185 NFRVSVDGEWLCL--KELQDIDVAGGTGNQAAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSK 247
                ..:...|||  :..|...:....|..|.:.:..|..|....|.|........|:..|.:|.
Mouse  1222 ----CCEPLTLCLSRQSQQASSLLTHLGMLAREHASHLLDGLPLSTLGSPRPSENPSAERKSHSS 1282

  Fly   248 RFSGLSTGSGSG---------------------GNAGGGGGLDITD-NARDTAEIERSNLVNICK 290
            ....|...:.|.                     |......||...: ..|..|.:....:...|
Mouse  1283 PKDSLPAFTASALAFLKSRSKILAMVACLRTSRGTKVSKPGLSWKELRGRREAPLTAEKVAQEC- 1346

  Fly   291 LVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPE 355
               :.||||                  |.|.|..|              ...|:.||....  |:
Mouse  1347 ---EHLLEQ------------------FPVFEAAL--------------LANWEPLQQASE--PK 1374

  Fly   356 AQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIV 420
             |.:.||:         .|:|.  |...|:....|..|..|.|..|.:|.....|.||.:.|
Mouse  1375 -QSLAASL---------CGQAN--LSTVLLGLHSSLALDILTEAFEGALVARDWPRALQLID--- 1424

  Fly   421 VIMG------ILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDAT 479
             :.|      .:|..:|:.|.....:|.......|.|.||..:.:.|..|..|.:|....|....
Mouse  1425 -VYGQDLDDLSIVQDSVLTCAAVCDKEGWQYLFPVKDASLRSQLALRFVDKWPLESCLEILAYCV 1488

  Fly   480 GQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQ-----AE 539
            ..   :||  |:....||.|.|      ::.:|                 ...:|.||     .:
Mouse  1489 SD---MAV--QEELKSELQRKL------MELRV-----------------YQKILGLQDPPVWCD 1525

  Fly   540 NQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEE--------RRKNSELEKELKLQVSLKAES 596
            .|.:| |..|.|.::.     .|...:....||.||        |.....|..:..|.:..::|.
Mouse  1526 WQTLR-SCCAEDPSAV-----MDMMLDSQEYELCEEWGRLYPIPREHLVSLHHKHLLHLLERSEH 1584

  Fly   597 DMAMKLLEK---------------DIHEKQDTIVSLRRQLDD--IKQINLEMYRKLQDCKASLTH 644
            |.|::||::               |.|....|...|...|..  ..::..:.:|::|   |....
Mouse  1585 DKALQLLQRIPDPTMCLEVTERSLDQHPSLATSHFLANYLTSHFYGELTTDRHREIQ---ALYMG 1646

  Fly   645 KTELMTKLEVQKEDMA----STIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAE 705
            ...|:|..|..:...|    |.:..||:...:.|.:..   .|..|||...:...:......|.:
Mouse  1647 SKVLLTLPEQHRASYARLSSSPLLMLEQLLMNMKVDWA---TTAVQTLHQLLAGQDIGFTLDEVD 1708

  Fly   706 SRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGI 770
            |.:.|            ...|..:|...|:|     :|:......|.:...|.|:::|.......
Mouse  1709 SLLSR------------YAGKALDLPYPLRE-----KRSADSMIHLQEPVHQASDSETLSRSSSA 1756

  Fly   771 QLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAM-PEAVGSPGIWAPDSIATHCTACERE-FNLTR 833
            :.|.:....|.:......:.:....:...::.: ||...:...|.||...:.|..|.|| |.:..
Mouse  1757 EFSAAAAPGSALVRSPSPKERAFPQTQPPVEFVPPETPPARDQWVPDETESVCMVCCREHFTMFN 1821

  Fly   834 RKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCYA 875
            |:||||.||.:.|.:||...:.:   :|....|.||||.||:
Mouse  1822 RRHHCRRCGRLVCGSCSTKKMVV---EGFRENPTRVCDQCYS 1860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	29/128 (23%)
		CASP_C	495..>634	CDD:285395	31/168 (18%)
		FYVE_RUFY1_like	813..874	CDD:277261	24/61 (39%)
Zfyve26	XP_017170500.1	FYVE_ZFY26	1800..1860	CDD:277263	25/62 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930