Protein Alignment CG31064 and eea-1

DIOPT Version :10

• Sequence 1: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_001024127.1
• Gene: eea-1 / 179832
• WormBaseID: WBGene00011696
• Length: 1205
• Species: Caenorhabditis elegans
• Alignment Length: 928
• Identity: 184/928 - (19%)
• Similarity: 340/928 - (36%)
• Gaps: 262/928 - (28%)

  Fly   131 KQQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVSVDGEWL 195
            |:...:.|::|....:|.....||....|:|......||:|...   .:.::  ..:|:|.||.|
 Worm   351 KRLEDKVQESQDALQMLSNINGSNEEQMISLNSKFERNTAERKR---IEAVF--EEKVTVQGERL 410

  Fly   196 CLKELQDIDVAGGTGNQAA------------------------QTSEKLAGGSSSQT-------- 228
            ...|:.::|:.....:..:                        ...||||......|
 Worm   411 KTLEMANLDLTNELASMGSLLDKERSLLEEKNKEISERDSSINDLKEKLAESEKKATKYKNELKE 475

  Fly   229 -GGFGSNYNVGSSSSKRNSK-RFSGLSTGSGSGGNA-----------------------GGGGGL 268
             .....|..:..:..:.||| ....:|.|.|....|                       ...|.|
 Worm   476 HADLVENLTLQLNKLQENSKDLMEKISAGEGGAKMAIEQLEQEKVKLTNELQTSSEKTKKASGEL 540

  Fly   269 -----DITDNARDTAEIERSNLVNICKLVVKELLEQSL--------RYGRMLDSDHLPLQHFFIV 320
                 ::....|| ||..|::.....| ..||..|:.|        |.|..           |:.
 Worm   541 EAKISELEKKLRD-AEASRTDKEQKWK-QEKESFERKLAEAEDEIKRKGER-----------FVE 592

  Fly   321 IEHVL--------GHGLRPKKGLLGP----------------------------RKELWDLLQSV 349
            :|..:        ...|:.|..|:..                            :|.:.|.:|.:
 Worm   593 MEKEMEEERQKATDRTLKLKDALVNSEKNLETIKKESEDREKIVREKDAHLEENKKRIEDAVQKL 657

  Fly   350 EHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALM 414
            |.....|:::.|||....|.            ::..:.:||:....|.|  .:|..:..:.....
 Worm   658 EEAEKRARELEASVSSRDTT------------VSTKESELSELKGKLTE--SNSFIEELKVQVEK 708

  Fly   415 MSDEI----VVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPE-DSAPPA 474
            :|:||    ..:..::..:...:.:...|.::.::|.        ||:...|.:|:.. .|....
 Worm   709 VSNEISEKQQEVENLMAEMRDKEAHWKTKRDEFEAQM--------LRNQEDNEEASSTLKSVQEQ 765

  Fly   475 LL---DATGQ--GNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLL 534
            |:   :.:|:  ..:|:|   |:.:|||...:...:.:.:.|.:.:....:
 Worm   766 LMKEKETSGEEKNQLISV---KSQLEELKTEVERLIRSEEEKTQEIEKLKS-------------- 813

  Fly   535 ALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMA 599
            |:.|..|...:.|:..::..|.....:.|.:.      :||.|:::|.:....|:..:..:|
 Worm   814 AVTATTQERDELTATSESLRTECENLNSKIQS------IEESRRHAEEKGSENLERMITEKS--- 869

  Fly   600 MKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQ-----DCKASLTHKTELMTKLEVQKEDM 659
              .|||||.|::.||.|::..| :.|...:|..:..|     :..:.::|.....:::|..:::|
 Worm   870 --RLEKDIEERESTIQSIQEAL-ETKDNEIESLKTTQRVVEDELVSKISHIESFNSRIEEFEKEM 931

  Fly   660 AS---TIDQLEKKWSHDKSNLGEILKTTSQ----------------TLTTQVTASEER--AARAE 703
            ||   ||::||.:.:.:...|.....|.||                |...::|:|:.:  |..|:
 Worm   932 ASGKRTIERLEAEKAEETEKLVVFTGTQSQKQEELEKLQKEIQEKETTIARMTSSKTQFEAMFAD 996

  Fly   704 AESRIEREWRISLQEKELKLKEKIANLQ----------------------------GCLKELSEE 740
            .:..:.:|.....:|.| :|.|:|.:|:                            ..::.:.:|
 Worm   997 VQQTLSKEINDKTEEIE-RLMERIDSLEKVNHSRIEELESRLTQRERVVESLEADLAAVRNIEQE 1060

  Fly   741 K-ERNGKLKADLD---KVRTQWSEAQTTLEE--LGIQLSVSKLKVSEMQDQERRQR--------Q 791
            | :...|||.:.|   |..|.|...:..|.|  ||   |.|.::..:.:.||.::|        .
 Worm  1061 KLDELQKLKEEFDELKKAETMWQAEKDMLIERCLG---SESDIEYEKERSQENKRRFDDALSAMH 1122

  Fly   792 LLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPL 856
            .|..:.||||...:...|.. |..|:.|.:||.|.:.|:||.||||||.||:|:|..||..::.:
 Worm  1123 ELGRANQSLQIDADRYSSRK-WLDDAEAINCTECGKVFSLTVRKHHCRVCGKIYCNPCSSKSVRI 1186

  Fly   857 LNAQGQPGKPVRVCDNCY 874
            .:|:    .|||.|:.|:
 Worm  1187 ASAK----NPVRACNTCF 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	30/202 (15%)
		Smc	<562..>807	CDD:440809	68/312 (22%)
		FYVE_RUFY1_like	813..874	CDD:277261	26/60 (43%)
eea-1	NP_001024127.1	SMC_prok_B	163..1029	CDD:274008	133/747 (18%)
		ClpA	<1030..>1126	CDD:440308	19/98 (19%)
		FYVE_EEA1	1141..1203	CDD:277269	27/65 (42%)