DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and RUNDC3A

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_016879524.1	Gene:	RUNDC3A / 10900	HGNCID:	16984	Length:	474	Species:	Homo sapiens

Alignment Length:	415	Identity:	105/415 - (25%)
Similarity:	171/415 - (41%)	Gaps:	113/415 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 GLSTGSGSGGNAGGGGGLDITDNARDTAEIERSNLVNICKLVVKELLEQSLRY-GRMLDSDHLPL 314
            |||:...|..|..                :||.||:.:|:..||.|||   :| ...:|......
Human    13 GLSSKKASSRNVA----------------VERKNLITVCRFSVKTLLE---KYTAEPIDDSSEEF 58

  Fly   315 QHFFIVIEHVLGHGLR---PKKGLLGP--------RKELWDLLQ----SVEHYCPEAQDITASVR 364
            .:|..::|.:|.|..:   |    .||        ::..||.::    .|.:.|      .:|:.
Human    59 VNFAAILEQILSHRFKACAP----AGPVSWFSSDGQRGFWDYIRLACSKVPNNC------VSSIE 113

  Fly   365 DLPTVRTHIGRARAWLRIALMQKKLSDYL-QALIEHREDSLFDYYEPHALMMSDEIVVIMGILVG 428
            ::..:.|...:.|||:|:|||:|::|:|: .||.:.|....|  |:..|:|:.||..::.|:|:|
Human   114 NMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRF--YDSGAIMLRDEATILTGMLIG 176

  Fly   429 LNVIDCNLCVKEEDLDSQQG-VIDFSLYLR-----------------SSSRNADAAPEDSAPPAL 475
            |:.||.:.|:|.|.||.:.. |||::.||:                 .||.:.|.:||....|.:
Human   177 LSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLV 241

  Fly   476 LDATG--------QGNMIAVLDQKNYIEELNR-------HLNATVGNLQAKVESLTTTNALMKED 525
            .|...        :.....|..||.|:|||.|       .|.|....||.::|.....|...|.:
Human   242 TDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRE 306

  Fly   526 LAIARNSLLALQAENQAMRQSTSA----GDNNST--------------GSGGSSDKDKEKASEEL 572
            |   ...:|.||.:...:..|..|    |....|              |:.|:|:.
Human   307 L---EGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNS--------- 359

  Fly   573 VEERRKNSELEKE-LKLQVSLKAES 596
             :..|::|.:..| |..:.||.::|
Human   360 -KLYRRHSFMSTEPLSAEASLSSDS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	39/138 (28%)
		CASP_C	495..>634	CDD:285395	29/128 (23%)
		FYVE_RUFY1_like	813..874	CDD:277261
RUNDC3A	XP_016879524.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740