DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31064 and rufy1

DIOPT Version :9

Sequence 1:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_002667361.2	Gene:	rufy1 / 100330077	ZFINID:	ZDB-GENE-090421-4	Length:	697	Species:	Danio rerio

Alignment Length:	689	Identity:	263/689 - (38%)
Similarity:	379/689 - (55%)	Gaps:	119/689 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 FSGLSTGSGSGGNAGGGGGLDITDN-------------ARDTAEIERSNLVNICKLVVKELLEQS 300
            |:..:|.:.|.|......||...|.             .:|...:|||||:::.||.:|.|::.|
Zfish    56 FARKATETLSSGVNHYSAGLKTPDTTQQHSSDPVKIAAVKDPVVVERSNLLSMMKLSIKVLIQSS 120

  Fly   301 LRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLG-PRKELWDLLQSVEHYCPEAQDITASVR 364
            |..||.|||::.|||.||:|:||.|.|||:.:|..:| ..|.:|..|:.:|..|||:.||..|||
Zfish   121 LSLGRTLDSEYPPLQQFFVVLEHCLKHGLKVRKSFIGLQNKSIWAPLEMIEKLCPESADIATSVR 185

  Fly   365 DLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGL 429
            |:|.::|.:|||||||.:||||||::||::.|| :|.|.|.::|||.||:|.:|..||:|:||||
Zfish   186 DMPGIKTGLGRARAWLHLALMQKKIADYMKVLI-NRRDLLGEFYEPGALVMEEEGAVIVGMLVGL 249

  Fly   430 NVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYI 494
            ||||.|||||.||||||..|||||:||:.             |.|.........|.|:||||:||
Zfish   250 NVIDANLCVKGEDLDSQVCVIDFSMYLKD-------------PQATESKQDDSKMTAILDQKHYI 301

  Fly   495 EELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGG 559
            |||||||:.||.:||||::||..||:.:.|:|..|.:.:.||:.|.:.::|      .|:.....
Zfish   302 EELNRHLSCTVTDLQAKMDSLEKTNSKLIEELTAATDRINALREEQEQLKQ------ENANILQS 360

  Fly   560 SSDKDKEKASEELV------------------------EERRKNSELEKELKLQVSLKAESDMAM 600
            |..|::....:..|                        ||:|...||:|||:||:.||.|.::||
Zfish   361 SQRKEEVTLQDSQVELETYRQTRQGLDEMYSVVWKQYKEEKRIRQELQKELELQIGLKQEMEVAM 425

  Fly   601 KLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQ 665
            ||||||.||||||:|:||:|||.:|.:||:|:.|.|........|.|.|..||.:...|.:.:.:
Zfish   426 KLLEKDTHEKQDTLVALRQQLDQVKNLNLQMFNKAQASDRVAQKKEEDMVHLEKKMIQMEAAMKE 490

  Fly   666 LEKKWSHDKSNLGEILKTTSQ-------TLTTQVTASEER-------AARAEAESRIEREWRISL 716
            ||::    ..|..::.|.|.:       .:..:|.|.::|       .|..|.|...|:|.|..|
Zfish   491 LEQR----LQNSEDVQKNTDEQQNEIRTEMKGKVNALQKRLSDLDTLRAGLETELSAEKEQRQIL 551

  Fly   717 QEKEL--------KLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLS 773
            | |||        :|:.::..|||...||.:       |:.:..:::....|.:..|:|:|:.||
Zfish   552 Q-KELQREQDNSAELRTQLQQLQGLQTELLD-------LRQEKQQLQQLCEEQEQALQEMGLHLS 608

  Fly   774 VSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHC 838
            .||||:.:.::..:    .|.|.|               |..|..||.|..|::||:::||||||
Zfish   609 QSKLKMEDFKEVNK----ALKGHA---------------WLKDDEATQCKQCQKEFSISRRKHHC 654

  Fly   839 RSCGEIFCKACSEHTLPLLNAQGQPG--KPVRVCDNCYA 875
            |:||:|:|..||.:.|.|      |.  |||||||.|::
Zfish   655 RNCGDIYCGNCSSNELAL------PSYPKPVRVCDVCHS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31064	NP_001287560.1	RUN	316..439	CDD:280855	67/123 (54%)
		CASP_C	495..>634	CDD:285395	65/162 (40%)
		FYVE_RUFY1_like	813..874	CDD:277261	31/62 (50%)
rufy1	XP_002667361.2	RUN	136..260	CDD:280855	68/124 (55%)
		TrbI	279..>525	CDD:305006	90/255 (35%)
		FYVE_RUFY1	624..694	CDD:277297	35/85 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584043
Domainoid	1	1.000	221	1.000	Domainoid score	I2543
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1401
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329099at33208
OrthoFinder	1	1.000	-	-		FOG0004337
OrthoInspector	1	1.000	-	-		otm24555
orthoMCL	1	0.900	-	-		OOG6_103035
Panther	1	1.100	-	-	LDO	PTHR45956
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760