Protein Alignment Ser and DNER

DIOPT Version :10

• Sequence 1: NP_524527.3
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_620711.3
• Gene: DNER / 92737
• HGNCID: 24456
• Length: 737
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 175/687 - (25%)
• Similarity: 252/687 - (36%)
• Gaps: 206/687 - (29%)

  Fly   358 EPCKHGGTC--------ENTAP---DKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSN 411
            :||::||.|        ::.||   ..|.|||..|:||..|::|..|||:.||.: |.|:..:|:
Human    51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-GNCSSSSSS 114

  Fly   412 RTQAQVYRTSHG-------------------RSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPG 457
            .:...:...:.|                   .|...|.::...:.:..|.:.|..||
Human   115 SSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQA-------- 171

  Fly   458 LVSLGSLQL------------QQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIG 510
            .|:|.:.|.            |.::.||..|..|:.          :..|||         .|:.
Human   172 TVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASS----------NSSAGG---------RLVS 217

  Fly   511 GFRCECPPE----------------WHGDVCQVDVNECEAPHSAGI----AANALLTTTATAIIG 555
               .|.|..                |  .|......:|.......:    |:..|:.......:|
Human   218 ---FEVPQNTSVKIRQDATASLILLW--KVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALG 277

  Fly   556 SN---------LSSTALLAALTSAVASTSLAIG-------PCINAKECRNQP--GSFACICKEGW 602
            :|         ::.:.:...||..|..::...|       .|....:|..:|  .:|:|.|:|.:
Human   278 NNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQY 342

  Fly   603 GGVTCAENLDDCVGQ-CRNGATCIDL-----VNDYRCACASGFKGRDCETDIDECATSPCRNGGE 661
            .|..| |..|.|..: |:|.|:|||.     .:::.|.|..|:.|..|::.||.|...|||||..
Human   343 VGTFC-EEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGAT 406

  Fly   662 CVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYYCHCPPDRAGKHCEQLRPL 725
            |:..:..|.|.||.||.||.|||..:.|..|||. .|.|......:.|:|.|...|..|.||...
Human   407 CISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDF 471

  Fly   726 CSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTF--CKCHV 788
            |:..||                                       .||:|.  .|||.  |.|..
Human   472 CALSPC---------------------------------------AHGTCR--SVGTSYKCLCDP 495

  Fly   789 GHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMP 853
            |:.|.:||...|||...||.|...|.|....:.|.|::.:.|..|.     .|.
Human   496 GYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE-----LYK----------- 544

  Fly   854 GAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVN 918
                                      |.|....|.||.||:|......|:||.||:|.:|.|::|
Human   545 --------------------------DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDIN 583

  Fly   919 ECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILL 955
            ||...||..|.:|:|...||:|.||.|..|..|||.|
Human   584 ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_524527.3	MNNL	83..238	CDD:462222
		DSL	220..282	CDD:128366
		EGF_CA	350..388	CDD:238011	14/40 (35%)
		EGF_CA	490..526	CDD:238011	8/51 (16%)
		EGF_CA	610..645	CDD:238011	12/40 (30%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	690..720	CDD:238011	9/30 (30%)
		EGF_CA	798..833	CDD:238011	11/34 (32%)
		EGF_CA	879..913	CDD:238011	14/33 (42%)
		EGF_CA	916..952	CDD:238011	15/35 (43%)
		VWC_out	<993..1053	CDD:214565
DNER	NP_620711.3	Interaction with NOTCH1. /evidence=ECO:0000250	44..133		25/82 (30%)
		EGF_CA	351..390	CDD:238011	12/38 (32%)
		EGF_CA	393..428	CDD:238011	17/34 (50%)
		EGF_CA	431..465	CDD:238011	10/33 (30%)
		EGF_CA	469..503	CDD:238011	13/74 (18%)
		EGF_CA	507..541	CDD:238011	11/33 (33%)
		EGF_CA	581..617	CDD:238011	15/35 (43%)
		DNER_C	635..737	CDD:437162
		Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000250	677..680