DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ser and DNER

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_620711.3 Gene:DNER / 92737 HGNCID:24456 Length:737 Species:Homo sapiens


Alignment Length:687 Identity:175/687 - (25%)
Similarity:252/687 - (36%) Gaps:206/687 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 EPCKHGGTC--------ENTAP---DKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSN 411
            :||::||.|        ::.||   ..|.|||..|:||..|::|..|||:.||.: |.|:..:|:
Human    51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-GNCSSSSSS 114

  Fly   412 RTQAQVYRTSHG-------------------RSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPG 457
            .:...:...:.|                   .|...|.::...:.:..|.:.|..||        
Human   115 SSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQA-------- 171

  Fly   458 LVSLGSLQL------------QQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIG 510
            .|:|.:.|.            |.::.||..|..|:.          :..|||         .|:.
Human   172 TVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASS----------NSSAGG---------RLVS 217

  Fly   511 GFRCECPPE----------------WHGDVCQVDVNECEAPHSAGI----AANALLTTTATAIIG 555
               .|.|..                |  .|......:|.......:    |:..|:.......:|
Human   218 ---FEVPQNTSVKIRQDATASLILLW--KVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALG 277

  Fly   556 SN---------LSSTALLAALTSAVASTSLAIG-------PCINAKECRNQP--GSFACICKEGW 602
            :|         ::.:.:...||..|..::...|       .|....:|..:|  .:|:|.|:|.:
Human   278 NNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQY 342

  Fly   603 GGVTCAENLDDCVGQ-CRNGATCIDL-----VNDYRCACASGFKGRDCETDIDECATSPCRNGGE 661
            .|..| |..|.|..: |:|.|:|||.     .:::.|.|..|:.|..|::.||.|...|||||..
Human   343 VGTFC-EEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGAT 406

  Fly   662 CVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYYCHCPPDRAGKHCEQLRPL 725
            |:..:..|.|.||.||.||.|||..:.|..|||. .|.|......:.|:|.|...|..|.||...
Human   407 CISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDF 471

  Fly   726 CSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTF--CKCHV 788
            |:..||                                       .||:|.  .|||.  |.|..
Human   472 CALSPC---------------------------------------AHGTCR--SVGTSYKCLCDP 495

  Fly   789 GHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMP 853
            |:.|.:||...|||...||.|...|.|....:.|.|::.:.|..|.     .|.           
Human   496 GYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE-----LYK----------- 544

  Fly   854 GAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVN 918
                                      |.|....|.||.||:|......|:||.||:|.:|.|::|
Human   545 --------------------------DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDIN 583

  Fly   919 ECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILL 955
            ||...||..|.:|:|...||:|.||.|..|..|||.|
Human   584 ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966
DSL 220..282 CDD:279722
EGF_CA 350..388 CDD:238011 14/40 (35%)
EGF_CA 490..526 CDD:238011 8/51 (16%)
EGF_CA 610..645 CDD:238011 12/40 (30%)
EGF_CA 647..683 CDD:238011 17/35 (49%)
EGF_CA 798..833 CDD:238011 11/34 (32%)
EGF_CA 879..913 CDD:238011 14/33 (42%)
EGF_CA 916..952 CDD:238011 15/35 (43%)
VWC_out <993..1053 CDD:214565
DNERNP_620711.3 Interaction with NOTCH1. /evidence=ECO:0000250 44..133 25/82 (30%)
EGF_CA 393..428 CDD:238011 17/34 (50%)
EGF_CA 431..465 CDD:238011 10/33 (30%)
EGF_CA 469..503 CDD:238011 13/74 (18%)
EGF_CA 507..541 CDD:238011 11/33 (33%)
EGF_CA 581..617 CDD:238011 15/35 (43%)
Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000250 677..680
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144851
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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