DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and DLK1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_003827.4	Gene:	DLK1 / 8788	HGNCID:	2907	Length:	383	Species:	Homo sapiens

Alignment Length:	353	Identity:	95/353 - (26%)
Similarity:	133/353 - (37%)	Gaps:	126/353 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 FGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGC 324
            |||...|:|                  |...|:|.:|.|:....|.|:|||:||||::|:..|||
Human    17 FGHSTYGAE------------------CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGC 63

  Fly   325 KHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEI 389
            .||.| |...:|:|...|.|.|||:|:..|.: .||.:..||.:.....|.|:||.|.||:.|:.
Human    64 LHGLC-GEPGQCICTDGWDGELCDRDVRACSS-APCANNRTCVSLDDGLYECSCAPGYSGKDCQK 126

  Fly   390 VEHPCATR--PCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNG 452
            .:.||...  ||::||||                                     :..||:|.:.
Human   127 KDGPCVINGSPCQHGGTC-------------------------------------VDDEGRASHA 154

  Fly   453 SSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECP 517
            |                      |.|..|::|..|||..:.|...|||:.|.|.|:.|.|||.||
Human   155 S----------------------CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCP 197

  Fly   518 PEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCI 582
            ..:....|...|..|                                            |..||.
Human   198 AGFIDKTCSRPVTNC--------------------------------------------ASSPCQ 218

  Fly   583 NAKEC-RNQPGSFACICKEGWGGVTCAE 609
            |...| ::...|:.|:||..:.|:||.:
Human   219 NGGTCLQHTQVSYECLCKPEFTGLTCVK 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	5/21 (24%)
		EGF_CA	350..388	CDD:238011	13/37 (35%)
		EGF_CA	490..526	CDD:238011	13/35 (37%)
		EGF_CA	610..645	CDD:238011	95/353 (27%)
		EGF_CA	647..683	CDD:238011
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
DLK1	NP_003827.4	EGF_CA	88..125	CDD:238011	13/37 (35%)
		EGF_CA	135..168	CDD:238011	14/91 (15%)
		EGF_CA	175..205	CDD:238011	12/29 (41%)
		EGF_CA	212..245	CDD:238011	12/76 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910